ISG15 antiviral mechanism

Skaug B, Chen ZJ. Emerging role of ISG15 in antiviral immunity. Cell. 2010 Oct 15;143(2):187–90. PMID: 20946978; PMCID: PMC2981609.; Jeon YJ, Yoo HM, Chung CH. ISG15 and immune diseases. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2010 May;1802(5):485–96. doi: 10.1016/j.bbadis.2010.02.006.; Dao CT, Zhang DE. ISG15: a ubiquitin-like enigma. Front Biosci. 2005 Sep 01;10():2701–22. doi: 10.2741/1730. PMID: 15970528.; Zhao C, Denison C, Huibregtse JM, Gygi S, Krug RM. Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10200–5. PMID: 16009940; PMCID: PMC1177427.; Malakhov MP, Kim KI, Malakhova OA, Jacobs BS, Borden EC, Zhang DE. High-throughput immunoblotting. Ubiquitiin-like protein ISG15 modifies key regulators of signal transduction. J Biol Chem. 2003 May 09;278(19):16608–13. doi: 10.1074/jbc.m208435200. PMID: 12582176.

Metabolites



Enzyme

EC Number name full name note
2.3.2.23 E2 ubiquitin-conjugating enzyme S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase
2.3.2.26 HECT-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming)
3.1.3.16 protein-serine/threonine phosphatase protein-serine/threonine-phosphate phosphohydrolase


Proteins

Protein ID name full name