Signaling by ERBB4
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Neuregulin 1 protects against ischemic brain injury via ErbB4 receptors by increasing GABAergic transmission. Neuroscience. 2015 Oct 29;307():151–9. doi: 10.1016/j.neuroscience.2015.08.047. PMID: 26318331.; Ahrens S, Jaramillo S, Yu K, Ghosh S, Hwang GR, Paik R, Lai C, He M, Huang ZJ, Li B. ErbB4 regulation of a thalamic reticular nucleus circuit for sensory selection. Nat Neurosci. 2015 Jan;18(1):104–11. PMID: 25501036; PMCID: PMC4281280.; Lu Y, Sun XD, Hou FQ, Bi LL, Yin DM, Liu F, Chen YJ, Bean JC, Jiao HF, Liu X, Li BM, Xiong WC, Gao TM, Mei L. Maintenance of GABAergic activity by neuregulin 1-ErbB4 in amygdala for fear memory. Neuron. 2014 Nov 19;84(4):835–46. doi: 10.1016/j.neuron.2014.09.029. PMID: 25451196.; Wali VB, Haskins JW, Gilmore-Hebert M, Platt JT, Liu Z, Stern DF. Convergent and divergent cellular responses by ErbB4 isoforms in mammary epithelial cells. Mol Cancer Res. 2014 Aug;12(8):1140–55. PMID: 24829397; PMCID: PMC4728083.; Hou XJ, Ni KM, Yang JM, Li XM. Neuregulin 1/ErbB4 enhances synchronized oscillations of prefrontal cortex neurons via inhibitory synapses. Neuroscience. 2014 Mar 07;261():107–17. doi: 10.1016/j.neuroscience.2013.12.040. PMID: 24374327.; Mitchell RM, Janssen MJ, Karavanova I, Vullhorst D, Furth K, Makusky A, Markey SP, Buonanno A. ErbB4 reduces synaptic GABAAcurrents independent of its receptor tyrosine kinase activity. Proc. Natl. Acad. Sci. U.S.A. 2013 Nov 11;110(48):19603–8. doi: 10.1073/pnas.1312791110.; Del Pino I, García-Frigola C, Dehorter N, Brotons-Mas JR, Alvarez-Salvado E, Martínez de Lagrán M, Ciceri G, Gabaldón MV, Moratal D, Dierssen M, Canals S, Marín O, Rico B. Erbb4 deletion from fast-spiking interneurons causes schizophrenia-like phenotypes. Neuron. 2013 Sep 18;79(6):1152–68. doi: 10.1016/j.neuron.2013.07.010. PMID: 24050403.; Paatero I, Jokilammi A, Heikkinen PT, Iljin K, Kallioniemi O, Jones FE, Jaakkola PM, Elenius K. Interaction with ErbB4 Promotes Hypoxia-inducible Factor-1a Signaling. 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Molecular and Cellular Biology. 2009 Feb 01;29(3):892–906. doi: 10.1128/mcb.00595-08.; Muraoka-Cook RS, Sandahl M, Hunter D, Miraglia L, Earp HS. Prolactin and ErbB4/HER4 Signaling Interact via Janus Kinase 2 to Induce Mammary Epithelial Cell Gene Expression Differentiation. Molecular Endocrinology. 2008 Oct;22(10):2307–21. doi: 10.1210/me.2008-0055.; Kaushansky A, Gordus A, Budnik BA, Lane WS, Rush J, MacBeath G. System-wide Investigation of ErbB4 Reveals 19 Sites of Tyr Phosphorylation that Are Unusually Selective in Their Recruitment Properties. Chemistry & Biology. 2008 Aug;15(8):808–17. doi: 10.1016/j.chembiol.2008.07.006.; Hayes NV, Blackburn E, Smart LV, Boyle MM, Russell GA, Frost TM, Morgan BJ, Baines AJ, Gullick WJ. Identification and characterization of novel spliced variants of neuregulin 4 in prostate cancer. Clin Cancer Res. 2007 Jun 01;13(11):3147–55. doi: 10.1158/1078-0432.ccr-06-2237. 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Molecular and Cellular Biology. 2006 Sep 01;26(17):6412–24. doi: 10.1128/mcb.01950-05.; Zhu Y, Sullivan LL, Nair SS, Williams CC, Pandey AK, Marrero L, Vadlamudi RK, Jones FE. Coregulation of estrogen receptor by ERBB4/HER4 establishes a growth-promoting autocrine signal in breast tumor cells. Cancer Res. 2006 Aug 15;66(16):7991–8. doi: 10.1158/0008-5472.can-05-4397. PMID: 16912174.; Naresh A, Long W, Vidal GA, Wimley WC, Marrero L, Sartor CI, Tovey S, Cooke TG, Bartlett JM, Jones FE. The ERBB4/HER4 intracellular domain 4ICD is a BH3-only protein promoting apoptosis of breast cancer cells. Cancer Res. 2006 Jun 15;66(12):6412–20. doi: 10.1158/0008-5472.can-05-2368. PMID: 16778220.; Arasada RR, Carpenter G. Secretase-dependent Tyrosine Phosphorylation of Mdm2 by the ErbB-4 Intracellular Domain Fragment. Journal of Biological Chemistry. 2005 Sep;280(35):30783–7. doi: 10.1074/jbc.m506057200.; Aqeilan RI, Donati V, Palamarchuk A, Trapasso F, Kaou M, Pekarsky Y, Sudol M, Croce CM. WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function. Cancer Res. 2005 Aug 01;65(15):6764–72. doi: 10.1158/0008-5472.can-05-1150. PMID: 16061658.; Schulze WX, Deng L, Mann M. Phosphotyrosine interactome of the ErbB-receptor kinase family. Mol Syst Biol. 2005;1():2005.0008. PMID: 16729043; PMCID: PMC1681463.; Williams CC, Allison JG, Vidal GA, Burow ME, Beckman BS, Marrero L, Jones FE. The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone. J Cell Biol. 2004 Nov 08;167(3):469–78. PMID: 15534001; PMCID: PMC2172499.; Omerovic J, Puggioni EM, Napoletano S, Visco V, Fraioli R, Frati L, Gulino A, Alimandi M. Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level. Exp Cell Res. 2004 Apr 01;294(2):469–79. doi: 10.1016/j.yexcr.2003.12.002. PMID: 15023535.; Amin DN, Perkins AS, Stern DF. Gene expression profiling of ErbB receptor and ligand-dependent transcription. Oncogene. 2004 Feb 19;23(7):1428–38. doi: 10.1038/sj.onc.1207257. PMID: 14973552.; Cheng QC, Tikhomirov O, Zhou W, Carpenter G. Ectodomain cleavage of ErbB-4: characterization of the cleavage site and m80 fragment. J Biol Chem. 2003 Oct 03;278(40):38421–7. doi: 10.1074/jbc.m302111200. PMID: 12869563.; Komuro A, Nagai M, Navin NE, Sudol M. WW Domain-containing Protein YAP Associates with ErbB-4 and Acts as a Co-transcriptional Activator for the Carboxyl-terminal Fragment of ErbB-4 That Translocates to the Nucleus. Journal of Biological Chemistry. 2003 Aug;278(35):33334–41. doi: 10.1074/jbc.m305597200.; Penington DJ, Bryant I, Riese DJ. Constitutively active ErbB4 and ErbB2 mutants exhibit distinct biological activities. Cell Growth Differ. 2002 Jun;13(6):247–56. PMID: 12114214.; Ni CY, Murphy MP, Golde TE, Carpenter G. gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. 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J Cell Biol. 1999 Oct 04;147(1):77–88. PMID: 10508857; PMCID: PMC2164978.; Riese DJ, Komurasaki T, Plowman GD, Stern DF. Activation of ErbB4 by the Bifunctional Epidermal Growth Factor Family Hormone Epiregulin Is Regulated by ErbB2. Journal of Biological Chemistry. 1998 May;273(18):11288–94. doi: 10.1074/jbc.273.18.11288.; Zhang D, Sliwkowski MX, Mark M, Frantz G, Akita R, Sun Y, Hillan K, Crowley C, Brush J, Godowski PJ. Neuregulin-3 (NRG3): A novel neural tissue-enriched protein that binds and activates ErbB4. Proc. Natl. Acad. Sci. U.S.A. 1997 Sep 02;94(18):9562–7. doi: 10.1073/pnas.94.18.9562.; Carraway KL, Weber JL, Unger MJ, Ledesma J, Yu N, Gassmann M, Lai C. Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases. Nature. 1997 May 29;387(6632):512–6. doi: 10.1038/387512a0. PMID: 9168115.; Elenius K, Paul S, Allison G, Sun J, Klagsbrun M. Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation. 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ErbB-3 and ErbB-4 function as the respective low and high affinity receptors of all Neu differentiation factor/heregulin isoforms. Journal of Biological Chemistry. 1994 Oct;269(40):25226–33. doi: 10.1016/s0021-9258(17)31521-1.; Hazan R, Margolis B, Dombalagian M, Ullrich A, Zilberstein A, Schlessinger J. Identification of autophosphorylation sites of HER2/neu. Cell Growth Differ. 1990 Jan;1(1):3–7. PMID: 1706616.