Signaling by TGFB family members
Vander Ark A, Cao J, Li X. TGF-ß receptors: In and beyond TGF-ß signaling. Cell Signal. 2018 Dec;52():112–20. doi: 10.1016/j.cellsig.2018.09.002. PMID: 30184463.; Budi EH, Duan D, Derynck R. Transforming Growth Factor-ß Receptors and Smads: Regulatory Complexity and Functional Versatility. Trends Cell Biol. 2017 Sep;27(9):658–72. doi: 10.1016/j.tcb.2017.04.005. PMID: 28552280.; Morikawa M, Derynck R, Miyazono K. TGF-ß and the TGF-ß Family: Context-Dependent Roles in Cell and Tissue Physiology. Cold Spring Harb Perspect Biol. 2016 May;8(5):a021873. doi: 10.1101/cshperspect.a021873.; Bilandzic M, Stenvers KL. Betaglycan: a multifunctional accessory. Mol Cell Endocrinol. 2011 Jun 06;339(1-2):180–9. doi: 10.1016/j.mce.2011.04.014. PMID: 21550381.; Miyazono K, Kamiya Y, Morikawa M. Bone morphogenetic protein receptors and signal transduction. Journal of Biochemistry. 2009 Sep 17;147(1):35–51. doi: 10.1093/jb/mvp148.; Kang JS, Liu C, Derynck R. New regulatory mechanisms of TGF-beta receptor function. Trends Cell Biol. 2009 Aug;19(8):385–94. doi: 10.1016/j.tcb.2009.05.008. PMID: 19648010.; Chen YG, Wang Q, Lin SL, Chang CD, Chuang J, Chung J, Ying SY. Activin signaling and its role in regulation of cell proliferation, apoptosis, and carcinogenesis. Exp Biol Med (Maywood). 2006 May;231(5):534–44. doi: 10.1177/153537020623100507. PMID: 16636301.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 2.4.2.- | |||
| 2.3.2.26 | HECT-type E3 ubiquitin transferase | [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming) | |
| 2.3.2.27 | RING-type E3 ubiquitin transferase | [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type) | |
| 2.3.2.34 | E2 NEDD8-conjugating enzyme | [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine:[E2 NEDD8-conjugating enzyme] [NEDD8-protein]-yl transferase | |
| 2.3.2.36 | RING-type E3 ubiquitin transferase (cysteine targeting) | [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (thioester bond-froming; RING-type) | |
| 2.4.2.30 | NAD+ ADP-ribosyltransferase | NAD+:poly(ADP-D-ribosyl)-acceptor ADP-D-ribosyl-transferase | |
| 2.7.11.22 | cyclin-dependent kinase | ATP:cyclin phosphotransferase | |
| 2.7.11.23 | [RNA-polymerase]-subunit kinase | ATP:[DNA-directed RNA polymerase] phosphotransferase | |
| 2.7.11.24 | mitogen-activated protein kinase | ATP:protein phosphotransferase (MAPKK-activated) | |
| 2.7.11.30 | receptor protein serine/threonine kinase | ATP:[receptor-protein] phosphotransferase | |
| 3.1.3.16 | protein-serine/threonine phosphatase | protein-serine/threonine-phosphate phosphohydrolase | |
| 3.1.3.95 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase | 1-phosphatidyl-1D-myo-inositol-3,5-bisphosphate 3-phosphohydrolase | |
| 3.4.19.12 | ubiquitinyl hydrolase 1 | ||
| 3.4.21.75 | Furin | ||
| 3.5.1.98 | histone deacetylase | histone amidohydrolase | |
| 3.6.5.2 | small monomeric GTPase | GTP phosphohydrolase (cell-regulating) | |
| 5.2.1.8 | peptidylprolyl isomerase | Peptidylproline cis-trans-isomerase |
Proteins
| Protein ID | name | full name |
|---|