Signaling by NOTCH1

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TBL1 and TBLR1 Phosphorylation on Regulated Gene Promoters Overcomes Dual CtBP and NCoR/SMRT Transcriptional Repression Checkpoints. Molecular Cell. 2008 Mar;29(6):755–66. doi: 10.1016/j.molcel.2008.01.020.; Koutelou E, Sato S, Tomomori-Sato C, Florens L, Swanson SK, Washburn MP, Kokkinaki M, Conaway RC, Conaway JW, Moschonas NK. Neuralized-like 1 (Neurl1) Targeted to the Plasma Membrane by N-Myristoylation Regulates the Notch Ligand Jagged1. Journal of Biological Chemistry. 2008 Feb;283(7):3846–53. doi: 10.1074/jbc.m706974200.; Welcker M, Clurman BE. FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Nat Rev Cancer. 2008 Feb;8(2):83–93. doi: 10.1038/nrc2290. PMID: 18094723.; Bray SJ, Takada S, Harrison E, Shen S, Ferguson-Smith AC. The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila. 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Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains. EMBO Reports. 2006 Oct 06;7(11):1147–53. doi: 10.1038/sj.embor.7400822.; Nam Y, Sliz P, Song L, Aster JC, Blacklow SC. Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell. 2006 Mar 10;124(5):973–83. doi: 10.1016/j.cell.2005.12.037. PMID: 16530044.; Mukherjee A, Veraksa A, Bauer A, Rosse C, Camonis J, Artavanis-Tsakonas S. Regulation of Notch signalling by non-visual beta-arrestin. Nat Cell Biol. 2005 Dec;7(12):1191–201. doi: 10.1038/ncb1327. PMID: 16284625.; Gustafsson MV, Zheng X, Pereira T, Gradin K, Jin S, Lundkvist J, Ruas JL, Poellinger L, Lendahl U, Bondesson M. Hypoxia requires notch signaling to maintain the undifferentiated cell state. Dev Cell. 2005 Nov;9(5):617–28. doi: 10.1016/j.devcel.2005.09.010. PMID: 16256737.; Eiraku M, Tohgo A, Ono K, Kaneko M, Fujishima K, Hirano T, Kengaku M. DNER acts as a neuron-specific Notch ligand during Bergmann glial development. Nat Neurosci. 2005 Jul;8(7):873–80. doi: 10.1038/nn1492. PMID: 15965470.; Koo BK, Yoon KJ, Yoo KW, Lim HS, Song R, So JH, Kim CH, Kong YY. Mind bomb-2 is an E3 ligase for Notch ligand. J Biol Chem. 2005 Jun 10;280(23):22335–42. doi: 10.1074/jbc.m501631200. PMID: 15824097.; Baladrón V, Ruiz-Hidalgo MJ, Nueda ML, Díaz-Guerra MJ, García-Ramírez JJ, Bonvini E, Gubina E, Laborda J. dlk acts as a negative regulator of Notch1 activation through interactions with specific EGF-like repeats. Exp Cell Res. 2005 Feb 15;303(2):343–59. doi: 10.1016/j.yexcr.2004.10.001. PMID: 15652348.; Yang LT, Nichols JT, Yao C, Manilay JO, Robey EA, Weinmaster G. Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1. Mol Biol Cell. 2005 Feb;16(2):927–42. PMID: 15574878; PMCID: PMC545923.; Fryer CJ, White JB, Jones KA. Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. Mol Cell. 2004 Nov 19;16(4):509–20. doi: 10.1016/j.molcel.2004.10.014. PMID: 15546612.; Fischer A, Schumacher N, Maier M, Sendtner M, Gessler M. The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. Genes Dev. 2004 Apr 15;18(8):901–11. doi: 10.1101/gad.291004.; Perissi V, Aggarwal A, Glass CK, Rose DW, Rosenfeld MG. A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. Cell. 2004 Feb 20;116(4):511–26. doi: 10.1016/s0092-8674(04)00133-3. PMID: 14980219.; Hu QD, Ang BT, Karsak M, Hu WP, Cui XY, Duka T, Takeda Y, Chia W, Sankar N, Ng YK, Ling EA, Maciag T, Small D, Trifonova R, Kopan R, Okano H, Nakafuku M, Chiba S, Hirai H, Aster JC, Schachner M, Pallen CJ, Watanabe K, Xiao ZC. F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation. 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Journal of Biological Chemistry. 2001 Sep;276(38):35847–53. doi: 10.1074/jbc.m103992200.; Kishi N, Tang Z, Maeda Y, Hirai A, Mo R, Ito M, Suzuki S, Nakao K, Kinoshita T, Kadesch T, Hui C, Artavanis-Tsakonas S, Okano H, Matsuno K. Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis. Intl J of Devlp Neuroscience. 2001 Feb;19(1):21–35. doi: 10.1016/s0736-5748(00)00071-x.; Leimeister C, Schumacher N, Steidl C, Gessler M. Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos. Mechanisms of Development. 2000 Nov;98(1-2):175–8. doi: 10.1016/s0925-4773(00)00459-7.; Shimizu K, Chiba S, Saito T, Kumano K, Hirai H. Physical Interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 Receptors. Biochemical and Biophysical Research Communications. 2000 Sep;276(1):385–9. doi: 10.1006/bbrc.2000.3469.; Maier MM, Gessler M. Comparative Analysis of the Human and Mouse Hey1 Promoter: Hey Genes Are New Notch Target Genes. Biochemical and Biophysical Research Communications. 2000 Aug;275(2):652–60. doi: 10.1006/bbrc.2000.3354.; Huppert SS, Le A, Schroeter EH, Mumm JS, Saxena MT, Milner LA, Kopan R. Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1. Nature. 2000 Jun 22;405(6789):966–70. doi: 10.1038/35016111. PMID: 10879540.; Zhou S, Fujimuro M, Hsieh JJ-, Chen L, Miyamoto A, Weinmaster G, Hayward SD. SKIP, a CBF1-Associated Protein, Interacts with the Ankyrin Repeat Domain of NotchIC To Facilitate NotchIC Function. Molecular and Cellular Biology. 2000 Apr 01;20(7):2400–10. doi: 10.1128/mcb.20.7.2400-2410.2000.; Brou C, Logeat F, Gupta N, Bessia C, LeBail O, Doedens JR, Cumano A, Roux P, Black RA, Israël A. A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. 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Metabolites



Enzyme

EC Number name full name note
2.3.1.-
2.3.1.48 histone acetyltransferase acetyl-CoA:[protein]-L-lysine acetyltransferase
2.3.2.26 HECT-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming)


Proteins

Protein ID name full name