Signaling by Hedgehog

Briscoe J, Thérond PP. The mechanisms of Hedgehog signalling and its roles in development and disease. Nature Reviews Molecular Cell Biology. 2013 May 30;14(7):416–29. doi: 10.1038/nrm3598.; Hui CC, Angers S. Gli proteins in development and disease. Annu Rev Cell Dev Biol. 2011;27():513–37. doi: 10.1146/annurev-cellbio-092910-154048. PMID: 21801010.; Jiang J, Hui C. Hedgehog Signaling in Development and Cancer. Developmental Cell. 2008 Dec;15(6):801–12. doi: 10.1016/j.devcel.2008.11.010.; Beachy PA, Karhadkar SS, Berman DM. Tissue repair and stem cell renewal in carcinogenesis. Nature. 2004 Nov 18;432(7015):324–31. doi: 10.1038/nature03100. PMID: 15549094.

Metabolites

Cholesterol

Formula: C27H46O (386.3548466)

CAS ID: 57-88-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

phosphate(3-)

Formula: O4P (94.953423)

CAS ID: 14265-44-2

palmitoyl-CoA(4-)

Formula: C37H62N7O17P3S (1001.3135592)

CAS ID: 1763-10-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

3',5'-cyclic AMP(1-)

Formula: C10H11N5O6P (328.0446936)

CAS ID: 62906-31-4



Enzyme

EC Number name full name note
2.3.1.-
2.3.2.26 HECT-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming)
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.16 G-protein-coupled receptor kinase ATP:[G-protein-coupled receptor] phosphotransferase
3.1.1.98 [Wnt protein] O-palmitoleoyl-L-serine hydrolase [Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine acylhydrolase
3.6.4.6 vesicle-fusing ATPase ATP phosphohydrolase (vesicle-fusing)
5.3.4.1 protein disulfide-isomerase Protein disulfide-isomerase


Proteins

Protein ID name full name