RA biosynthesis pathway
Das BC, Thapa P, Karki R, Das S, Mahapatra S, Liu T, Torregroza I, Wallace DP, Kambhampati S, Van Veldhuizen P, Verma A, Ray SK, Evans T. Retinoic acid signaling pathways in development and diseases. Bioorganic & Medicinal Chemistry. 2014 Jan;22(2):673–83. doi: 10.1016/j.bmc.2013.11.025.; Napoli JL. Physiological insights into all-trans-retinoic acid biosynthesis. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2012 Jan;1821(1):152–67. doi: 10.1016/j.bbalip.2011.05.004.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.1.1.1 | alcohol dehydrogenase | alcohol:NAD+ oxidoreductase | |
| 1.1.1.105 | all-trans-retinol dehydrogenase (NAD+) | all-trans retinol:NAD+ oxidoreductase | |
| 1.1.1.300 | NADP-retinol dehydrogenase | retinol:NADP+ oxidoreductase | |
| 1.14.14.1 | unspecific monooxygenase | substrate,NADPH-hemoprotein reductase:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing) | |
| 1.2.1.19 | aminobutyraldehyde dehydrogenase | 4-aminobutanal:NAD+ 1-oxidoreductase | |
| 1.2.1.28 | benzaldehyde dehydrogenase (NAD+) | benzaldehyde:NAD+ oxidoreductase | |
| 1.2.1.3 | aldehyde dehydrogenase (NAD+) | aldehyde:NAD+ oxidoreductase | |
| 1.2.1.32 | aminomuconate-semialdehyde dehydrogenase | 2-aminomuconate-6-semialdehyde:NAD+ 6-oxidoreductase | |
| 1.2.1.36 | retinal dehydrogenase | retinal:NAD+ oxidoreductase |
Proteins
| Protein ID | name | full name |
|---|