Regulated Necrosis

Ros U, Pedrera L, Garcia-Saez AJ. Partners in Crime: The Interplay of Proteins and Membranes in Regulated Necrosis. Int J Mol Sci. 2020 Mar 30;21(7). PMID: 32244433; PMCID: PMC7177786.; Mocarski ES, Kaiser WJ, Livingston-Rosanoff D, Upton JW, Daley-Bauer LP. True grit: programmed necrosis in antiviral host defense, inflammation, and immunogenicity. J Immunol. 2014 Mar 01;192(5):2019–26. PMID: 24563506; PMCID: PMC3934821.; Vanden Berghe T, Linkermann A, Jouan-Lanhouet S, Walczak H, Vandenabeele P. Regulated necrosis: the expanding network of non-apoptotic cell death pathways. Nat Rev Mol Cell Biol. 2014 Feb;15(2):135–47. doi: 10.1038/nrm3737. PMID: 24452471.; Nikoletopoulou V, Markaki M, Palikaras K, Tavernarakis N. Crosstalk between apoptosis, necrosis and autophagy. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2013 Dec;1833(12):3448–59. doi: 10.1016/j.bbamcr.2013.06.001.; Galluzzi L, Maiuri MC, Vitale I, Zischka H, Castedo M, Zitvogel L, Kroemer G. Cell death modalities: classification and pathophysiological implications. Cell Death Differ. 2007 Jul;14(7):1237–43. doi: 10.1038/sj.cdd.4402148. PMID: 17431418.; Rello S, Stockert JC, Moreno V, Gámez A, Pacheco M, Juarranz A, Cañete M, Villanueva A. Morphological criteria to distinguish cell death induced by apoptotic and necrotic treatments. Apoptosis. 2005 Jan;10(1):201–8. doi: 10.1007/s10495-005-6075-6. PMID: 15711936.

Metabolites



Enzyme

EC Number name full name note
2.3.2.31 RBR-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:acceptor protein ubiquitin transferase (isopeptide bond-forming; RBR-type)
2.4.1.255 protein O-GlcNAc transferase UDP-N-acetyl-D-glucosamine:protein-O-beta-N-acetyl-D-glucosaminyl transferase
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
3.4.21.79 granzyme B
3.4.22.36 caspase-1
3.4.22.56 caspase-3
3.4.22.61 caspase-8
3.6.4.10 non-chaperonin molecular chaperone ATPase ATP phosphohydrolase (polypeptide-polymerizing)


Proteins

Protein ID name full name