GBP-mediated host defense
Sauter D, Kirchhoff F. Antiviral mechanisms of guanylate-binding protein 5: versatile inhibition of multiple viral glycoproteins. mBio. 2024 Nov 13;15(11):e0237424. PMID: 39404361; PMCID: PMC11559056.; Veler H, Lun CM, Waheed AA, Freed EO. Guanylate-binding protein 5 antagonizes viral glycoproteins independently of furin processing. mBio. 2024 Oct 16;15(10):e0208624. PMID: 39212413; PMCID: PMC11492990.; Kuhm T, Taisne C, de Agrela Pinto C, Gross L, Giannopoulou EA, Huber ST, Pardon E, Steyaert J, Tans SJ, Jakobi AJ. Structural basis of antimicrobial membrane coat assembly by human GBP1. Nat Struct Mol Biol. 2024 Oct 11;32(1):172–84. doi: 10.1038/s41594-024-01400-9.; Zhu S, Bradfield CJ, Maminska A, Park ES, Kim BH, Kumar P, Huang S, Kim M, Zhang Y, Bewersdorf J, MacMicking JD. Native architecture of a human GBP1 defense complex for cell-autonomous immunity to infection. Science. 2024 Mar;383(6686):eabm9903. PMID: 38422126; PMCID: PMC12091997.; Weismehl M, Chu X, Kutsch M, Lauterjung P, Herrmann C, Kudryashev M, Daumke O. Structural insights into the activation mechanism of antimicrobial GBP1. EMBO J. 2024 Jan 24;43(4):615–36. doi: 10.1038/s44318-023-00023-y.; Fisch D, Pfleiderer MM, Anastasakou E, Mackie GM, Wendt F, Liu X, Clough B, Lara-Reyna S, Encheva V, Snijders AP, Bando H, Yamamoto M, Beggs AD, Mercer J, Shenoy AR, Wollscheid B, Maslowski KM, Galej WP, Frickel EM. PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection. Science. 2023 Oct 06;382(6666):eadg2253. PMID: 37797010; PMCID: PMC7615196.; Dickinson MS, Kutsch M, Sistemich L, Hernandez D, Piro AS, Needham D, Lesser CF, Herrmann C, Coers J. LPS-aggregating proteins GBP1 and GBP2 are each sufficient to enhance caspase-4 activation both in cellulo and in vitro. Proc Natl Acad Sci U S A. 2023 Apr 11;120(15):e2216028120. 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Metabolites
Diphosphoric acid,P-(3,7,11-trimethyl-2,6,10-dodecatrienyl) ester
Formula: C15H28O7P2 (382.1310198)
CAS ID: 13058-04-3
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 3.6.1.- | |||
| 2.5.1.58 | protein farnesyltransferase | farnesyl-diphosphate:protein-cysteine farnesyltransferase | |
| 2.5.1.59 | protein geranylgeranyltransferase type I | geranylgeranyl-diphosphate:protein-cysteine geranyltransferase | |
| 2.7.11.1 | non-specific serine/threonine protein kinase | ATP:protein phosphotransferase (non-specific) | |
| 3.4.21.75 | Furin | ||
| 3.4.22.36 | caspase-1 |
Proteins
| Protein ID | name | full name |
|---|