Purinergic signaling in leishmaniasis infection
Figueiredo ABD, Souza-Testasicca MC, Afonso LCC. Purinergic signaling and infection by Leishmania : A new approach to evasion of the immune response. Biomedical Journal. 2016 Aug;39(4):244–50. doi: 10.1016/j.bj.2016.08.004.; Cekic C, Linden J. Purinergic regulation of the immune system. Nat Rev Immunol. 2016 Mar;16(3):177–92. doi: 10.1038/nri.2016.4. PMID: 26922909.; Idzko M, Ferrari D, Eltzschig HK. Nucleotide signalling during inflammation. Nature. 2014 May 15;509(7500):310–7. PMID: 24828189; PMCID: PMC4222675.; Coutinho-Silva R, Ojcius DM. Role of extracellular nucleotides in the immune response against intracellular bacteria and protozoan parasites. Microbes and Infection. 2012 Nov;14(14):1271–7. doi: 10.1016/j.micinf.2012.05.009.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 3.6.4.- | |||
| 1.14.14.18 | heme oxygenase (biliverdin-producing) | protoheme,NADPH-hemoprotein reductase:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating) | |
| 3.1.3.35 | thymidylate 5'-phosphatase | thymidylate 5'-phosphohydrolase | |
| 3.1.3.5 | 5'-nucleotidase | 5'-ribonucleotide phosphohydrolase | |
| 3.1.3.89 | 5'-deoxynucleotidase | 2'-deoxyribonucleoside 5'-monophosphate phosphohydrolase | |
| 3.1.3.91 | 7-methylguanosine nucleotidase | N7-methyl-GMP phosphohydrolase | |
| 3.1.3.99 | IMP-specific 5'-nucleotidase | inosine 5'-phosphate phosphohydrolase | |
| 3.4.21.20 | cathepsin G | ||
| 3.4.22.36 | caspase-1 | ||
| 3.6.1.5 | apyrase | nucleoside triphosphate phosphohydrolase (nucleoside monophosphoate-forming) | |
| 3.6.1.6 | nucleoside diphosphate phosphatase | nucleoside-diphosphate phosphohydrolase |
Proteins
| Protein ID | name | full name |
|---|