7alpha-Hydroxy-3-oxo-4-cholestenoate (BioCAD00000005472)

placenta

Metabolite Card

Formula: C27H42O4 (430.3083)
SMILES: [H][C@@]1(CC[C@@]2([H])[C@]3([H])[C@H](O)CC4=CC(=O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)C(O)=O

Synonyms [en]

7alpha-Hydroxy-3-oxocholest-4-en-26-Oic acid; 7-Hoca; 7alpha-Hydroxy-3-oxo-4-cholestenoate; 7alpha-hydroxy-3-oxo-4-cholestenoic acid; 7alpha-hydroxy-3-oxocholest-4-en-27-oic acid; 7 alpha-hydroxy-3-oxo-4-cholestenoic acid

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

7alpha-Hydroxy-3-oxo-4-cholestenoate. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000005472). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

7alpha-Hydroxy-3-oxo-4-cholestenoate, also known as 7-Hoca, is a member of the class of compounds known as monohydroxy bile acids, alcohols, and derivatives. Thes compounds are bile acids, alcohols, or any of their derivatives bearing a hydroxyl group. 7alpha-Hydroxy-3-oxo-4-cholestenoate is practically insoluble (in water) and a weakly acidic compound (based on its pKa). 7alpha-Hydroxy-3-oxo-4-cholestenoate is involved in metabolic disorders such as 27-hydroxylase deficiency, familial hypercholanemia (FHCA), and Zellweger syndrome. 7alpha-Hydroxy-3-oxo-4-cholestenoate is involved in the primary bile acid biosynthesis pathway. 7alpha-Hydroxy-3-oxo-4-cholestenoate is created from either 3beta,7alpha-dihydroxy-5-cholestenoate or 7alpha,26-dihydroxy-4-cholesten-3-one through the actions of HSD3B7 (EC 1.1.1.181) or CYP27A (EC 1.14.13.15), respectively.

Extracellular
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 115538-85-7
  • PubChem: 3081085
  • ChEBI: ChEBI:178592
  • ChEBI: ChEBI:83036
  • HMDB: HMDB0012458
  • LipidMaps: LMST04030149
  • KEGG: C17337
  • NCBI MeSH: 7 alpha-hydroxy-3-oxo-4-cholestenoic acid
  • Metlin: METLIN_43146
  • Metlin: METLIN_63317
  • Coconut NaturalProduct: CNP0346749.1
  • Coconut NaturalProduct: CNP0346749.2

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R08725 C17336 + 2 C00007 + 2 C00005 + 2 C00080<=>C17337 + 2 C00006 + 3 C00001
KEGG:R08728 1.1.1.181 3beta,7alpha-dihydroxy-5-cholestenoate:NAD+ 3-oxidoreductase
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Organism Source

Taxonomy Source

Pathway Synthetic

pathway id name
PathBank:SMP0120468 Congenital Bile Acid Synthesis Defect Type III
PathBank:SMP0000318 Congenital Bile Acid Synthesis Defect Type III
PathBank:SMP0120697 Familial Hypercholanemia (FHCA)
PathBank:SMP0120463 Cerebrotendinous Xanthomatosis (CTX)
PathBank:SMP0120467 Congenital Bile Acid Synthesis Defect Type II
PathBank:SMP0120495 Zellweger Syndrome
PathBank:SMP0000035 Bile Acid Biosynthesis
PathBank:SMP0000314 Congenital Bile Acid Synthesis Defect Type II
PathBank:SMP0000315 Cerebrotendinous Xanthomatosis (CTX)
PathBank:SMP0087329 Bile Acid Biosynthesis
PathBank:SMP0120652 27-Hydroxylase Deficiency
PathBank:SMP0120688 Congenital Bile Acid Synthesis Defect Type III
PathBank:SMP0120477 Familial Hypercholanemia (FHCA)
PathBank:SMP0000317 Familial Hypercholanemia (FHCA)
PathBank:SMP0087236 Bile Acid Biosynthesis
PathBank:SMP0120683 Cerebrotendinous Xanthomatosis (CTX)
PathBank:SMP0120687 Congenital Bile Acid Synthesis Defect Type II
PathBank:SMP0120715 Zellweger Syndrome
PathBank:SMP0120871 27-Hydroxylase Deficiency
PathBank:SMP0000316 Zellweger Syndrome
View All Pathways