EC: 6.2.1.7

cholate-CoA ligase (cholate:CoA ligase (AMP-forming))

enzyme lambda metabolic reaction experiment
uniprot:Q9ES38 [cholate---CoA ligase(Enzyme) wildtype]

3alpha,7alpha,12alpha_Trihydroxy_5beta_cholestanoate + ATP + Coenzyme_A -> AMP + Diphosphate + 3alpha,7alpha,12alpha_Trihydroxy_5beta_cholestanoyl_CoA		 (( (Vmax * S1) ) / (Km + S1)) buffer: 0.1 M Tris-HCl, 10 mM MgCl2, 12 mM Dithiothreitol, 0.67 mg/ml BSA
PH: 8
Temperature: 37

Pathways

pathway id name
BioCyc:HUMAN_PWY-7592 arachidonate biosynthesis III (metazoa)
BioCyc:META_PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals)
BioCyc:META_FAO-PWY fatty acid β-oxidation I
BioCyc:HUMAN_PWY-5143 fatty acid activation
BioCyc:HUMAN_PWY66-387 fatty acid α-oxidation
BioCyc:META_PWY66-387 fatty acid α-oxidation II
BioCyc:HUMAN_PWY-6000 γ-linolenate biosynthesis
BioCyc:HUMAN_PWY-5972 stearate biosynthesis
BioCyc:HUMAN_FAO-PWY fatty acid β-oxidation
BioCyc:HUMAN_PWY66-391 fatty acid β-oxidation (peroxisome)
BioCyc:META_PWY-6000 γ-linolenate biosynthesis II (animals)
BioCyc:META_PWY66-391 fatty acid β-oxidation VI (peroxisome)
BioCyc:META_PWY-7754 bile acids degradation
BioCyc:META_PWY-5972 stearate biosynthesis I (animals and fungi)
BioCyc:MOUSE_FAO-PWY fatty acid β-oxidation I
BioCyc:MOUSE_PWY-6000 γ-linolenate biosynthesis II (animals)
BioCyc:MOUSE_PWY-5136 fatty acid β-oxidation II (core pathway)
Reactome:R-HSA-75105 Fatty acyl-CoA biosynthesis
Reactome:R-HSA-194068 Bile acid and bile salt metabolism
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-556833 Metabolism of lipids
Reactome:R-MMU-75105 Fatty acyl-CoA biosynthesis
Reactome:R-MMU-8957322 Metabolism of steroids
Reactome:R-MMU-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Reactome:R-RNO-8978868 Fatty acid metabolism
Reactome:R-RNO-389599 Alpha-oxidation of phytanate
Reactome:R-RNO-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Reactome:R-HSA-556833 Metabolism of lipids
Reactome:R-HSA-8978868 Fatty acid metabolism
Reactome:R-HSA-389599 Alpha-oxidation of phytanate
Reactome:R-HSA-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Reactome:R-MMU-8978868 Fatty acid metabolism
Reactome:R-MMU-389599 Alpha-oxidation of phytanate
Reactome:R-MMU-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Reactome:R-RNO-390918 Peroxisomal lipid metabolism
Reactome:R-RNO-192105 Synthesis of bile acids and bile salts
Reactome:R-RNO-159418 Recycling of bile acids and salts
Reactome:R-HSA-390247 Beta-oxidation of very long chain fatty acids
Reactome:R-HSA-192105 Synthesis of bile acids and bile salts
Reactome:R-HSA-159418 Recycling of bile acids and salts
Reactome:R-MMU-390247 Beta-oxidation of very long chain fatty acids
Reactome:R-MMU-194068 Bile acid and bile salt metabolism
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-556833 Metabolism of lipids
Reactome:R-RNO-75105 Fatty acyl-CoA biosynthesis
Reactome:R-RNO-8957322 Metabolism of steroids
Reactome:R-RNO-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-390918 Peroxisomal lipid metabolism
Reactome:R-HSA-8957322 Metabolism of steroids
Reactome:R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Reactome:R-MMU-390918 Peroxisomal lipid metabolism
Reactome:R-MMU-192105 Synthesis of bile acids and bile salts
Reactome:R-MMU-159418 Recycling of bile acids and salts
Reactome:R-RNO-390247 Beta-oxidation of very long chain fatty acids
Reactome:R-RNO-194068 Bile acid and bile salt metabolism
WikiPathways:WP5176 Disorders of bile acid synthesis and biliary transport
PathBank:SMP0120468 Congenital Bile Acid Synthesis Defect Type III
PathBank:SMP0000318 Congenital Bile Acid Synthesis Defect Type III
PathBank:SMP0120697 Familial Hypercholanemia (FHCA)
PathBank:SMP0120749 Refsum Disease
PathBank:SMP0120463 Cerebrotendinous Xanthomatosis (CTX)
PathBank:SMP0120467 Congenital Bile Acid Synthesis Defect Type II
PathBank:SMP0120495 Zellweger Syndrome
PathBank:SMP0000035 Bile Acid Biosynthesis
PathBank:SMP0000314 Congenital Bile Acid Synthesis Defect Type II
PathBank:SMP0000315 Cerebrotendinous Xanthomatosis (CTX)
PathBank:SMP0087329 Bile Acid Biosynthesis
PathBank:SMP0120652 27-Hydroxylase Deficiency
PathBank:SMP0120688 Congenital Bile Acid Synthesis Defect Type III
PathBank:SMP0120477 Familial Hypercholanemia (FHCA)
PathBank:SMP0000450 Phytanic Acid Peroxisomal Oxidation
PathBank:SMP0000317 Familial Hypercholanemia (FHCA)
PathBank:SMP0087312 Phytanic Acid Peroxisomal Oxidation
PathBank:SMP0120683 Cerebrotendinous Xanthomatosis (CTX)
PathBank:SMP0120687 Congenital Bile Acid Synthesis Defect Type II
PathBank:SMP0120715 Zellweger Syndrome
PathBank:SMP0120871 27-Hydroxylase Deficiency
PathBank:SMP0000451 Refsum Disease
PathBank:SMP0000316 Zellweger Syndrome
PathBank:SMP0000720 27-Hydroxylase Deficiency
PathBank:SMP0063601 Bile Acid Biosynthesis