bile acids degradation

Ridlon JM, Hylemon PB. Identification and characterization of two bile acid coenzyme A transferases from Clostridium scindens, a bile acid 7a-dehydroxylating intestinal bacterium. Journal of Lipid Research. 2012 Jan;53(1):66–76. doi: 10.1194/jlr.m020313.; Ye H, Mallonee DH, Wells JE, Björkhem I, Hylemon PB. The bile acid-inducible baiF gene from Eubacterium sp. strain VPI 12708 encodes a bile acid-coenzyme A hydrolase. Journal of Lipid Research. 1999 Jan;40(1):17–23. doi: 10.1016/s0022-2275(20)33335-6.; Dawson JA, Mallonee DH, Björkhem I, Hylemon PB. Expression and characterization of a C24 bile acid 7 alpha-dehydratase from Eubacterium sp. strain VPI 12708 in Escherichia coli. Journal of Lipid Research. 1996 Jan;37(6):1258–67. doi: 10.1016/s0022-2275(20)39155-0.; White BA, Cacciapuoti AF, Fricke RJ, Whitehead TR, Mosbach EH, Hylemon PB. Cofactor requiremets for 7 alpha-dehydroxylation of cholic and chenodeoxycholic acid in cell extracts of the intestinal anaerobic bacterium, Eubacterium species V.P.I. 13708. Journal of Lipid Research. 1981 Aug;22(6):891–8. doi: 10.1016/s0022-2275(20)37326-0.

Metabolites

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

Copper

Formula: Cu (62.929599)

CAS ID: 7440-50-8

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Mercury(2+)

Formula: Hg (201.970632)

CAS ID: 14302-87-5

N-Ethylmaleimide

Formula: C6H7NO2 (125.0476762)

CAS ID: 128-53-0

cholate

Formula: C24H39O5 (407.2797344)

CAS ID: 298-43-1

lithocholate

Formula: C24H39O3 (375.28990439999995)

CAS ID:

glycochenodeoxycholate

Formula: C26H42NO5 (448.30628220000006)

CAS ID:

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9



Enzyme

EC Number name full name note
2.3.1.-
1.1.1.395 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 3alpha-hydroxy-bile-acid-CoA-ester:NAD+ 3-oxidoreductase
1.3.1.114 3-dehydro-bile acid DELTA4,6-reductase 3-oxocholan-24-oyl-CoA DELTA4,6-oxidoreductase
1.3.1.115 3-oxocholoyl-CoA 4-desaturase 3-oxocholoyl-CoA DELTA4-oxidoreductase
2.8.3.25 bile acid CoA-transferase lithocholoyl-CoA:cholate CoA-transferase
3.5.1.24 choloylglycine hydrolase 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine amidohydrolase
3.5.1.74 chenodeoxycholoyltaurine hydrolase chenodeoxycholoyltaurine amidohydrolase
4.2.1.106 bile-acid 7alpha-dehydratase 7alpha,12alpha-dihydroxy-3-oxochol-4-enoyl-CoA hydro-lyase (12alpha-hydroxy-3-oxochola-4,6-dienoyl-CoA-forming)
6.2.1.7 cholate-CoA ligase cholate:CoA ligase (AMP-forming)


Proteins

Protein ID name full name
B0NAQ4 baiN 3-dehydro-bile acid delta(4,6)-reductase
B4YST4 baiK Bile acid CoA-transferase BaiK
P07914 baiA1 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 1/3
P19337 baiA2 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2
P19409 baiB Bile acid--coenzyme A ligase
P19410 baiCD 3-oxocholoyl-CoA 4-desaturase
P19412 baiE Bile acid 7alpha-dehydratase
P19413 baiF Bile acid CoA-transferase BaiF
Q9KK62 bsh Bile salt hydrolase/transferase