Peroxisomal lipid metabolism

Wanders RJ, Waterham HR. Biochemistry of mammalian peroxisomes revisited. Annu Rev Biochem. 2006;75():295–332. doi: 10.1146/annurev.biochem.74.082803.133329. PMID: 16756494.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydrogen peroxide

Formula: H2O2 (34.0054792)

CAS ID: 7722-84-1

L-Carnitine

Formula: C7H15NO3 (161.105188)

CAS ID: 541-15-1

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

O-Propanoylcarnitine

Formula: C10H19NO4 (217.1314014)

CAS ID: 20064-19-1

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Pristanal

Formula: C19H38O (282.2922498)

CAS ID: 105373-75-9

Acetyl-L-carnitine

Formula: C9H17NO4 (203.1157522)

CAS ID: 3040-38-8

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

succinate(2-)

Formula: C4H4O4 (116.01095839999999)

CAS ID: 56-14-4

acetate

Formula: C2H3O2 (59.0133038)

CAS ID: 71-50-1

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.1.1.n12
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase (S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase
1.1.3.15 (S)-2-hydroxy-acid oxidase (S)-2-hydroxy-acid:oxygen 2-oxidoreductase
1.14.11.18 phytanoyl-CoA dioxygenase phytanoyl-CoA, 2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating)
1.17.99.3 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA:acceptor 24-oxidoreductase (24R-hydroxylating)
1.2.1.3 aldehyde dehydrogenase (NAD+) aldehyde:NAD+ oxidoreductase
1.2.1.94 farnesal dehydrogenase farnesal:NAD+ oxidoreductase
1.3.1.124 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] (3E)-3-enoyl-CoA:NADP+ 4-oxidoreductase
1.3.1.38 trans-2-enoyl-CoA reductase (NADPH) acyl-CoA:NADP+ trans-2-oxidoreductase
1.3.3.6 acyl-CoA oxidase acyl-CoA:oxygen 2-oxidoreductase
2.3.1.137 carnitine O-octanoyltransferase octanoyl-CoA:L-carnitine O-octanoyltransferase
2.3.1.155 acetyl-CoA C-myristoyltransferase myristoyl-CoA:acetyl-CoA C-myristoyltransferase
2.3.1.16 acetyl-CoA C-acyltransferase acyl-CoA:acetyl-CoA C-acyltransferase
2.3.1.176 propanoyl-CoA C-acyltransferase 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase
2.3.1.7 carnitine O-acetyltransferase acetyl-CoA:carnitine O-acetyltransferase
2.3.1.9 acetyl-CoA C-acetyltransferase acetyl-CoA:acetyl-CoA C-acetyltransferase
3.1.2.1 acetyl-CoA hydrolase acetyl-CoA hydrolase
3.1.2.11 acetoacetyl-CoA hydrolase acetoacetyl-CoA hydrolase
3.1.2.2 palmitoyl-CoA hydrolase palmitoyl-CoA hydrolase
3.1.2.27 choloyl-CoA hydrolase choloyl-CoA hydrolase
3.1.2.3 succinyl-CoA hydrolase succinyl-CoA hydrolase
3.1.2.5 hydroxymethylglutaryl-CoA hydrolase (S)-3-hydroxy-3-methylglutaryl-CoA hydrolase
3.6.1.77 coenzyme A diphosphatase coenzyme A 4'-phosphopantetheine phosphohydrolase
4.1.1.9 malonyl-CoA decarboxylase malonyl-CoA carboxy-lyase (acetyl-CoA-forming)
4.1.2.63 2-hydroxyacyl-CoA lyase 2-hydroxy-3-methyl fatty-CoA formyl-CoA lyase (2-methyl branched fatty aldehyde-forming)
4.2.1.107 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase [(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA-forming]
4.2.1.119 enoyl-CoA hydratase 2 (3R)-3-hydroxyacyl-CoA hydro-lyase
4.2.1.17 enoyl-CoA hydratase (3S)-3-hydroxyacyl-CoA hydro-lyase
5.1.99.4 alpha-methylacyl-CoA racemase 2-Methylacyl-CoA 2-epimerase
5.3.3.8 DELTA3-DELTA2-enoyl-CoA isomerase (3Z/3E)-alk-3-enoyl-CoA (2E)-isomerase
6.2.1.15 arachidonate-CoA ligase arachidonate:CoA ligase (AMP-forming)
6.2.1.24 phytanate-CoA ligase phytanate:CoA ligase (AMP-forming)
6.2.1.3 long-chain-fatty-acid-CoA ligase long-chain fatty acid:CoA ligase (AMP-forming)
6.2.1.7 cholate-CoA ligase cholate:CoA ligase (AMP-forming)


Proteins

Protein ID name full name