Recycling of bile acids and salts

Kullak-Ublick GA, Stieger B, Meier PJ. Enterohepatic bile salt transporters in normal physiology and liver disease. Gastroenterology. 2004 Jan;126(1):322–42. doi: 10.1053/j.gastro.2003.06.005. PMID: 14699511.; Trauner M, Boyer JL. Bile salt transporters: molecular characterization, function, and regulation. Physiol Rev. 2003 Apr;83(2):633–71. doi: 10.1152/physrev.00027.2002. PMID: 12663868.; Mihalik SJ, Steinberg SJ, Pei Z, Park J, Kim DG, Heinzer AK, Dacremont G, Wanders RJA, Cuebas DA, Smith KD, Watkins PA. Participation of Two Members of the Very Long-chain Acyl-CoA Synthetase Family in Bile Acid Synthesis and Recycling. Journal of Biological Chemistry. 2002 Jul;277(27):24771–9. doi: 10.1074/jbc.m203295200.; Falany CN, Johnson MR, Barnes S, Diasio RB. Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase. Journal of Biological Chemistry. 1994 Jul;269(30):19375–9. doi: 10.1016/s0021-9258(17)32178-6.; Killenberg PG. Measurement and subcellular distribution of choloyl-CoA synthetase and bile acid-CoA:amino acid N-acyltransferase activities in rat liver. Journal of Lipid Research. 1978 Jan;19(1):24–31. doi: 10.1016/s0022-2275(20)41573-1.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Sodium cation

Formula: Na (22.98977)

CAS ID: 17341-25-2

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
6.2.1.-
2.3.1.65 bile acid-CoA:amino acid N-acyltransferase choloyl-CoA:glycine N-choloyltransferase
3.1.2.2 palmitoyl-CoA hydrolase palmitoyl-CoA hydrolase
3.1.2.27 choloyl-CoA hydrolase choloyl-CoA hydrolase
6.2.1.3 long-chain-fatty-acid-CoA ligase long-chain fatty acid:CoA ligase (AMP-forming)
6.2.1.7 cholate-CoA ligase cholate:CoA ligase (AMP-forming)
7.6.2.2 ABC-type xenobiotic transporter ATP phosphohydrolase (ABC-type, xenobiotic-exporting)
7.6.2.3 ABC-type glutathione-S-conjugate transporter ATP + H2O + glutathione-S-conjugate[side 1] = ADP + phosphate + glutathione-S-conjugate[side 2]


Proteins

Protein ID name full name