Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Russell DW. The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem. 2003;72():137–74. doi: 10.1146/annurev.biochem.72.121801.161712. PMID: 12543708.; Javitt NB. Cholesterol, Hydroxycholesterols, and Bile Acids. Biochemical and Biophysical Research Communications. 2002 Apr;292(5):1147–53. doi: 10.1006/bbrc.2001.2013.; Björkhem I, Lütjohann D, Diczfalusy U, Ståhle L, Ahlborg G, Wahren J. Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation. Journal of Lipid Research. 1998 Aug;39(8):1594–600. doi: 10.1016/s0022-2275(20)32188-x.
Metabolites
(24S)-Cholest-5-ene-3beta,7alpha,24-triol
Formula: C27H46O3 (418.34467659999996)
CAS ID: 245523-67-5
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.1.1.- | |||
| 1.1.1.181 | cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase | cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase | |
| 1.14.15.15 | cholestanetriol 26-monooxygenase | 5beta-cholestane-3alpha,7alpha,12alpha-triol,adrenodoxin:oxygen oxidoreductase (26-hydroxylating) | |
| 1.3.1.3 | DELTA4-3-oxosteroid 5beta-reductase | 5beta-cholestan-3-one:NADP+ 4,5-oxidoreductase | |
| 5.1.99.4 | alpha-methylacyl-CoA racemase | 2-Methylacyl-CoA 2-epimerase | |
| 6.2.1.15 | arachidonate-CoA ligase | arachidonate:CoA ligase (AMP-forming) | |
| 6.2.1.24 | phytanate-CoA ligase | phytanate:CoA ligase (AMP-forming) | |
| 6.2.1.3 | long-chain-fatty-acid-CoA ligase | long-chain fatty acid:CoA ligase (AMP-forming) | |
| 6.2.1.7 | cholate-CoA ligase | cholate:CoA ligase (AMP-forming) |
Proteins
| Protein ID | name | full name |
|---|