Alpha-oxidation of phytanate

Wanders RJA, Jansen GA, Lloyd MD. Phytanic acid alpha-oxidation, new insights into an old problem: a review. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2003 Mar;1631(2):119–35. doi: 10.1016/s1388-1981(03)00003-9.; Baxter JH. Absorption of chlorophyll phytol in normal man and in patients with Refsum's disease. Journal of Lipid Research. 1968 Sep;9(5):636–41. doi: 10.1016/s0022-2275(20)42711-7.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Pristanal

Formula: C19H38O (282.2922498)

CAS ID: 105373-75-9

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

succinate(2-)

Formula: C4H4O4 (116.01095839999999)

CAS ID: 56-14-4

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

thiamine(1+) diphosphate(3-)

Formula: C12H16N4O7P2S (422.0214926)

CAS ID:

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
6.2.1.-
1.14.11.18 phytanoyl-CoA dioxygenase phytanoyl-CoA, 2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating)
1.2.1.3 aldehyde dehydrogenase (NAD+) aldehyde:NAD+ oxidoreductase
1.2.1.94 farnesal dehydrogenase farnesal:NAD+ oxidoreductase
1.3.1.38 trans-2-enoyl-CoA reductase (NADPH) acyl-CoA:NADP+ trans-2-oxidoreductase
4.1.2.63 2-hydroxyacyl-CoA lyase 2-hydroxy-3-methyl fatty-CoA formyl-CoA lyase (2-methyl branched fatty aldehyde-forming)
6.2.1.15 arachidonate-CoA ligase arachidonate:CoA ligase (AMP-forming)
6.2.1.24 phytanate-CoA ligase phytanate:CoA ligase (AMP-forming)
6.2.1.3 long-chain-fatty-acid-CoA ligase long-chain fatty acid:CoA ligase (AMP-forming)
6.2.1.7 cholate-CoA ligase cholate:CoA ligase (AMP-forming)


Proteins

Protein ID name full name