EC: 2.7.4.2

phosphomevalonate kinase (ATP:(R)-5-phosphomevalonate phosphotransferase)

enzyme lambda metabolic reaction experiment
uniprot:Q15126 [phosphomevalonate kinase(Enzyme) wildtype his-tagged]

(R)_5_Diphosphomevalonate + ADP -> ATP + (R)_5_Phosphomevalonate
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM MOPS, 200 mM KCl, 1 MM DTT, 10 mM MgCl2, coupled assay: ATP production was coupled to the reduction of NADP+ with hexokinase/glucose-6-phosphate dehydrogenase (3 U per assay)
PH: 7
Temperature: 30
uniprot:Q15126 [phosphomevalonate kinase(Enzyme) wildtype his-tagged]

ADP + (R)_5_Diphosphomevalonate -> (R)_5_Phosphomevalonate + ATP
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM MOPS, 200 mM KCl, 1 MM DTT, 10 mM MgCl2, coupled assay: ATP production was coupled to the reduction of NADP+ with hexokinase/glucose-6-phosphate dehydrogenase (3 U per assay)
PH: 7
Temperature: 30
uniprot:Q15126 [phosphomevalonate kinase(Enzyme) wildtype]

ATP + (R)_5_Phosphomevalonate -> ADP + (R)_5_Diphosphomevalonate
(( (V * B) ) / (Km + B)) buffer: 50 mM MOPS-KOH, 6 mM MgCl2, 10 mM KF, 1 mM phosphoenolpyruvate, 0.2 mM NADH, 10 U/ml pyruvate kinase, 10 U/ml lactate dehydrogenase
PH: 7
Temperature: 25
uniprot:Q15126 [phosphomevalonate kinase(Enzyme) wildtype]

(R)_5_Phosphomevalonate + ATP -> ADP + (R)_5_Diphosphomevalonate
(( (V * A) ) / (Km + A)) buffer: 50 mM MOPS-KOH, 6 mM MgCl2, 10 mM KF, 1 mM phosphoenolpyruvate, 0.2 mM NADH, 10 U/ml pyruvate kinase, 10 U/ml lactate dehydrogenase
PH: 7
Temperature: 25
- [phosphomevalonate kinase(Enzyme) wildtype]

(R)_5_Phosphomevalonate + ATP -> (R)_5_Diphosphomevalonate + ADP
(( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris/HCl, 20 mM MgCl2, 10 mM DTT, 5 mM p-Coumarate
PH: 7.4
Temperature: 37
- [phosphomevalonate kinase(Enzyme) wildtype]

(R)_5_Phosphomevalonate + ATP -> (R)_5_Diphosphomevalonate + ADP
(( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris/HCl, 20 mM MgCl2, 10 mM DTT, 5 mM p-Coumarate
PH: 7.4
Temperature: 37
uniprot:Q97UL6 [phosphomevalonate kinase(Enzyme) wildtype]

ATP + (R)_5_Phosphomevalonate -> (R)_5_Diphosphomevalonate + ADP
(( (Vmax * A) ) / (Km + A)) buffer: 73 mM potassium phosphate, 10 U/ml pyruvate kinase, 10 U/ml lactate dehydrogenase, 5 mM phosphoenolpyruvate, 0.16 mM NADH, 5 mM MgCl2
PH: 7
Temperature: 37
uniprot:Q837E1 [phosphomevalonate kinase(Enzyme) wildtype]

(R)_5_Phosphomevalonate + ATP -> (R)_5_Diphosphomevalonate + ADP
(( (Vmax * A) ) / (Km + A)) buffer: 50 mM Tris, 75 mM KCl, 5 mM MgCl2, 5 mM MnCl2, 2.5 mM phosphoenolpyruvate, ~0.16 mM NADH, 10 mM DTT, 5 units L-lactate dehydrogenase, 10 units pyruvate kinase
PH: 8
Temperature: 25
uniprot:Q837E1 [phosphomevalonate kinase(Enzyme) wildtype]

(R)_5_Phosphomevalonate + ATP -> ADP + (R)_5_Diphosphomevalonate
(( (Vmax * A) ) / (Km + A)) buffer: 50 mM Tris, 75 mM KCl, 5 mM MgCl2, 5 mM MnCl2, 2.5 mM phosphoenolpyruvate, ~0.16 mM NADH, 10 mM DTT, 5 units L-lactate dehydrogenase, 10 units pyruvate kinase
PH: 8
Temperature: 25
uniprot:Q15126 [phosphomevalonate kinase(Enzyme) wildtype his-tagged]

(R)_5_Phosphomevalonate + ATP -> (R)_5_Diphosphomevalonate + ADP
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM MOPS, 200 mM KCl, 1 MM DTT, 10 mM MgCl2, coupled assay: couple ADP production to oxidation of NADH with pyruvate kinase/lactate dehydrogenase (3 U per assay)
PH: 7
Temperature: 30
uniprot:Q15126 [phosphomevalonate kinase(Enzyme) mutant K17M his-tagged]

(R)_5_Phosphomevalonate + ATP -> ADP + (R)_5_Diphosphomevalonate
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM MOPS, 200 mM KCl, 1 MM DTT, 10 mM MgCl2, coupled assay: couple ADP production to oxidation of NADH with pyruvate kinase/lactate dehydrogenase (3 U per assay)
PH: 7
Temperature: 30
uniprot:Q15126 [phosphomevalonate kinase(Enzyme) mutant K17M his-tagged]

(R)_5_Diphosphomevalonate + ADP -> (R)_5_Phosphomevalonate + ATP
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM MOPS, 200 mM KCl, 1 MM DTT, 10 mM MgCl2, coupled assay: ATP production was coupled to the reduction of NADP+ with hexokinase/glucose-6-phosphate dehydrogenase (3 U per assay)
PH: 7
Temperature: 30
uniprot:Q15126 [phosphomevalonate kinase(Enzyme) wildtype his-tagged]

(R)_5_Phosphomevalonate + ATP -> ADP + (R)_5_Diphosphomevalonate
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM MOPS, 200 mM KCl, 1 MM DTT, 10 mM MgCl2, coupled assay: couple ADP production to oxidation of NADH with pyruvate kinase/lactate dehydrogenase (3 U per assay)
PH: 7
Temperature: 30
uniprot:Q15126 [phosphomevalonate kinase(Enzyme) mutant K17M his-tagged]

ATP + (R)_5_Phosphomevalonate -> ADP + (R)_5_Diphosphomevalonate
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM MOPS, 200 mM KCl, 1 MM DTT, 10 mM MgCl2, coupled assay: couple ADP production to oxidation of NADH with pyruvate kinase/lactate dehydrogenase (3 U per assay)
PH: 7
Temperature: 30
uniprot:Q15126 [phosphomevalonate kinase(Enzyme) mutant D23N his-tagged]

ADP + (R)_5_Diphosphomevalonate -> ATP + (R)_5_Phosphomevalonate
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM MOPS, 200 mM KCl, 1 MM DTT, 10 mM MgCl2, coupled assay: ATP production was coupled to the reduction of NADP+ with hexokinase/glucose-6-phosphate dehydrogenase (3 U per assay)
PH: 7
Temperature: 30
uniprot:Q15126 [phosphomevalonate kinase(Enzyme) mutant D23N his-tagged]

ATP + (R)_5_Phosphomevalonate -> (R)_5_Diphosphomevalonate + ADP
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM MOPS, 200 mM KCl, 1 MM DTT, 10 mM MgCl2, coupled assay: couple ADP production to oxidation of NADH with pyruvate kinase/lactate dehydrogenase (3 U per assay)
PH: 7
Temperature: 30
uniprot:Q15126 [phosphomevalonate kinase(Enzyme) mutant D23N his-tagged]

ATP + (R)_5_Phosphomevalonate -> ADP + (R)_5_Diphosphomevalonate
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM MOPS, 200 mM KCl, 1 MM DTT, 10 mM MgCl2, coupled assay: couple ADP production to oxidation of NADH with pyruvate kinase/lactate dehydrogenase (3 U per assay)
PH: 7
Temperature: 30
uniprot:Q15126 [phosphomevalonate kinase(Enzyme) mutant D23N his-tagged]

ADP + (R)_5_Diphosphomevalonate -> ATP + (R)_5_Phosphomevalonate
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM MOPS, 200 mM KCl, 1 MM DTT, 10 mM MgCl2, coupled assay: ATP production was coupled to the reduction of NADP+ with hexokinase/glucose-6-phosphate dehydrogenase (3 U per assay)
PH: 7
Temperature: 30
uniprot:Q15126 [phosphomevalonate kinase(Enzyme) mutant K22M his-tagged]

(R)_5_Diphosphomevalonate + ADP -> (R)_5_Phosphomevalonate + ATP
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM MOPS, 200 mM KCl, 1 MM DTT, 10 mM MgCl2, coupled assay: ATP production was coupled to the reduction of NADP+ with hexokinase/glucose-6-phosphate dehydrogenase (3 U per assay)
PH: 7
Temperature: 30
uniprot:Q15126 [phosphomevalonate kinase(Enzyme) mutant K22B his-tagged]

(R)_5_Phosphomevalonate + ATP -> ADP + (R)_5_Diphosphomevalonate
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM MOPS, 200 mM KCl, 1 MM DTT, 10 mM MgCl2, coupled assay: couple ADP production to oxidation of NADH with pyruvate kinase/lactate dehydrogenase (3 U per assay)
PH: 7
Temperature: 30
uniprot:Q15126 [phosphomevalonate kinase(Enzyme) mutant R18Q his-tagged]

ATP + (R)_5_Phosphomevalonate -> (R)_5_Diphosphomevalonate + ADP
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM MOPS, 200 mM KCl, 1 MM DTT, 10 mM MgCl2, coupled assay: couple ADP production to oxidation of NADH with pyruvate kinase/lactate dehydrogenase (3 U per assay)
PH: 7
Temperature: 30
uniprot:Q15126 [phosphomevalonate kinase(Enzyme) mutant K17M his-tagged]

ADP + (R)_5_Diphosphomevalonate -> ATP + (R)_5_Phosphomevalonate
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM MOPS, 200 mM KCl, 1 MM DTT, 10 mM MgCl2, coupled assay: ATP production was coupled to the reduction of NADP+ with hexokinase/glucose-6-phosphate dehydrogenase (3 U per assay)
PH: 7
Temperature: 30
uniprot:Q15126 [phosphomevalonate kinase(Enzyme) mutant R18Q his-tagged]

ADP + (R)_5_Diphosphomevalonate -> (R)_5_Phosphomevalonate + ATP
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM MOPS, 200 mM KCl, 1 MM DTT, 10 mM MgCl2, coupled assay: ATP production was coupled to the reduction of NADP+ with hexokinase/glucose-6-phosphate dehydrogenase (3 U per assay)
PH: 7
Temperature: 30
uniprot:Q15126 [phosphomevalonate kinase(Enzyme) mutant K19M his-tagged]

ADP + (R)_5_Diphosphomevalonate -> ATP + (R)_5_Phosphomevalonate
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM MOPS, 200 mM KCl, 1 MM DTT, 10 mM MgCl2, coupled assay: ATP production was coupled to the reduction of NADP+ with hexokinase/glucose-6-phosphate dehydrogenase (3 U per assay)
PH: 7
Temperature: 30
uniprot:Q15126 [phosphomevalonate kinase(Enzyme) mutant K19M his-tagged]

ATP + (R)_5_Phosphomevalonate -> (R)_5_Diphosphomevalonate + ADP
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM MOPS, 200 mM KCl, 1 MM DTT, 10 mM MgCl2, coupled assay: couple ADP production to oxidation of NADH with pyruvate kinase/lactate dehydrogenase (3 U per assay)
PH: 7
Temperature: 30
uniprot:Q15126 [phosphomevalonate kinase(Enzyme) mutant R18Q his-tagged]

ATP + (R)_5_Phosphomevalonate -> (R)_5_Diphosphomevalonate + ADP
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM MOPS, 200 mM KCl, 1 MM DTT, 10 mM MgCl2, coupled assay: couple ADP production to oxidation of NADH with pyruvate kinase/lactate dehydrogenase (3 U per assay)
PH: 7
Temperature: 30
uniprot:Q15126 [phosphomevalonate kinase(Enzyme) mutant K19M his-tagged]

ATP + (R)_5_Phosphomevalonate -> ADP + (R)_5_Diphosphomevalonate
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM MOPS, 200 mM KCl, 1 MM DTT, 10 mM MgCl2, coupled assay: couple ADP production to oxidation of NADH with pyruvate kinase/lactate dehydrogenase (3 U per assay)
PH: 7
Temperature: 30
uniprot:Q15126 [phosphomevalonate kinase(Enzyme) mutant K19M his-tagged]

(R)_5_Diphosphomevalonate + ADP -> (R)_5_Phosphomevalonate + ATP
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM MOPS, 200 mM KCl, 1 MM DTT, 10 mM MgCl2, coupled assay: ATP production was coupled to the reduction of NADP+ with hexokinase/glucose-6-phosphate dehydrogenase (3 U per assay)
PH: 7
Temperature: 30
uniprot:Q15126 [phosphomevalonate kinase(Enzyme) mutant R18Q his-tagged]

ADP + (R)_5_Diphosphomevalonate -> ATP + (R)_5_Phosphomevalonate
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM MOPS, 200 mM KCl, 1 MM DTT, 10 mM MgCl2, coupled assay: ATP production was coupled to the reduction of NADP+ with hexokinase/glucose-6-phosphate dehydrogenase (3 U per assay)
PH: 7
Temperature: 30

Pathways

pathway id name
BioCyc:META_PWY-922 mevalonate pathway I
BioCyc:MOUSE_PWY66-5 superpathway of cholesterol biosynthesis
BioCyc:HUMAN_PWY66-5 superpathway of cholesterol biosynthesis
BioCyc:HUMAN_PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
BioCyc:YEAST_ERGOSTEROL-SYN-PWY superpathway of ergosterol biosynthesis
BioCyc:YEAST_PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
BioCyc:YEAST_PWY-922 mevalonate pathway
BioCyc:ARA_PWY-922 mevalonate pathway I
BioCyc:META_PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
BioCyc:META_PWY-7391 isoprene biosynthesis II (engineered)
BioCyc:HUMAN_PWY-922 mevalonate pathway
BioCyc:META_ERGOSTEROL-SYN-PWY superpathway of ergosterol biosynthesis I
BioCyc:META_PWY66-5 superpathway of cholesterol biosynthesis
BioCyc:MOUSE_PWY-922 mevalonate pathway I
PlantCyc:ARA_PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
PlantCyc:ARA_PWY-922 mevalonate pathway I
Reactome:R-DME-9969896 Lanosterol biosynthesis
Reactome:R-HSA-9969896 Lanosterol biosynthesis
Reactome:R-MMU-9969896 Lanosterol biosynthesis
Reactome:R-SSC-9969896 Lanosterol biosynthesis
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-556833 Metabolism of lipids
Reactome:R-MMU-8957322 Metabolism of steroids
Reactome:R-DME-1430728 Metabolism
Reactome:R-HSA-556833 Metabolism of lipids
Reactome:R-HSA-191273 Cholesterol biosynthesis
Reactome:R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
Reactome:R-SSC-1430728 Metabolism
Reactome:R-SSC-556833 Metabolism of lipids
Reactome:R-DME-8957322 Metabolism of steroids
Reactome:R-MMU-191273 Cholesterol biosynthesis
Reactome:R-SSC-8957322 Metabolism of steroids
Reactome:R-DME-556833 Metabolism of lipids
Reactome:R-DME-191273 Cholesterol biosynthesis
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-8957322 Metabolism of steroids
Reactome:R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)
Reactome:R-SSC-191273 Cholesterol biosynthesis
WikiPathways:WP4190 Mevalonate arm of cholesterol biosynthesis pathway
PathBank:SMP0120464 CHILD Syndrome
PathBank:SMP0120472 Desmosterolosis
PathBank:SMP0120512 Lysosomal Acid Lipase Deficiency (Wolman Disease)
PathBank:SMP0120573 Cholesteryl Ester Storage Disease
PathBank:SMP0000023 Steroid Biosynthesis
PathBank:SMP0000387 CHILD Syndrome
PathBank:SMP0000112 Risedronate Action Pathway
PathBank:SMP0000508 Cholesteryl Ester Storage Disease
PathBank:SMP0002438 Cholesterol Biosynthesis and Metabolism CE(12:0)
PathBank:SMP0120515 Smith-Lemli-Opitz Syndrome (SLOS)
PathBank:SMP0120576 Wolman Disease
PathBank:SMP0121055 Mevalonate Pathway
PathBank:SMP0000389 Smith-Lemli-Opitz Syndrome (SLOS)
PathBank:SMP0000319 Lysosomal Acid Lipase Deficiency (Wolman Disease)
PathBank:SMP0000082 Simvastatin Action Pathway
PathBank:SMP0000111 Cerivastatin Action Pathway
PathBank:SMP0000131 Atorvastatin Action Pathway
PathBank:SMP0000511 Wolman Disease
PathBank:SMP0002381 Steroid Biosynthesis
PathBank:SMP0002436 Cholesterol biosynthesis and metabolism CE(10:0)
PathBank:SMP0002441 Cholesterol biosynthesis and metabolism CE(18:0)
PathBank:SMP0087233 Steroid Biosynthesis
PathBank:SMP0070041 Cholesterol Biosynthesis and Metabolism
PathBank:SMP0120465 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2)
PathBank:SMP0120549 Hypercholesterolemia
PathBank:SMP0120574 Hyper-IgD Syndrome
PathBank:SMP0000386 Desmosterolosis
PathBank:SMP0000089 Pravastatin Action Pathway
PathBank:SMP0000095 Alendronate Action Pathway
PathBank:SMP0000099 Lovastatin Action Pathway
PathBank:SMP0000117 Pamidronate Action Pathway
PathBank:SMP0000509 Hyper-IgD Syndrome
PathBank:SMP0120575 Mevalonic Aciduria
PathBank:SMP0121209 Mevalonate Pathway
PathBank:SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2)
PathBank:SMP0000079 Ibandronate Action Pathway
PathBank:SMP0000092 Rosuvastatin Action Pathway
PathBank:SMP0000209 Hypercholesterolemia
PathBank:SMP0000107 Zoledronate Action Pathway
PathBank:SMP0000119 Fluvastatin Action Pathway
PathBank:SMP0000510 Mevalonic Aciduria
PathBank:SMP0002384 Terpenoid Backbone Biosynthesis
PathBank:SMP0002435 Cholesterol biosynthesis and metabolism CE(14:0)
PathBank:SMP0002440 Cholesterol Biosynthesis and Metabolism CE(16:0)
PathBank:SMP0063670 Steroid Biosynthesis