Activation of gene expression by SREBF (SREBP)

Weber LW, Boll M, Stampfl A. Maintaining cholesterol homeostasis: sterol regulatory element-binding proteins. World J Gastroenterol. 2004 Nov 01;10(21):3081–7. PMID: 15457548; PMCID: PMC4611246.; Eberlé D, Hegarty B, Bossard P, Ferré P, Foufelle F. SREBP transcription factors: master regulators of lipid homeostasis. Biochimie. 2004 Nov;86(11):839–48. doi: 10.1016/j.biochi.2004.09.018. PMID: 15589694.; Pai J, Guryev O, Brown MS, Goldstein JL. Differential Stimulation of Cholesterol and Unsaturated Fatty Acid Biosynthesis in Cells Expressing Individual Nuclear Sterol Regulatory Element-binding Proteins. Journal of Biological Chemistry. 1998 Oct;273(40):26138–48. doi: 10.1074/jbc.273.40.26138.

Metabolites



Enzyme

EC Number name full name note
2.5.1.-
1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase (3R)-3-hydroxyacyl-[acyl-carrier protein]:NADP+ oxidoreductase
1.14.14.154 sterol 14alpha-demethylase sterol,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (14-methyl cleaving)
1.14.14.17 squalene monooxygenase squalene,NADPH-hemoprotein:oxygen oxidoreductase (2,3-epoxidizing
1.14.19.1 stearoyl-CoA 9-desaturase stearoyl-CoA,ferrocytochrome-b5:oxygen oxidoreductase (9,10-dehydrogenating)
1.14.19.20 DELTA7-sterol 5(6)-desaturase DELTA7-sterol,ferrocytochrome b5:oxygen oxidoreductase 5,6-dehydrogenating
1.3.1.21 7-dehydrocholesterol reductase cholesterol:NADP+ DELTA7-oxidoreductase
1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) acyl-[acyl-carrier protein]:NADP+ oxidoreductase (Re-specific)
1.3.1.70 DELTA14-sterol reductase 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP+ DELTA14-oxidoreductase
2.3.1.15 glycerol-3-phosphate 1-O-acyltransferase acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
2.3.1.199 very-long-chain 3-oxoacyl-CoA synthase malonyl-CoA:very-long-chain acyl-CoA malonyltransferase (decarboxylating and thioester-hydrolysing)
2.3.1.38 [acyl-carrier-protein] S-acetyltransferase acetyl-CoA:[acyl-carrier protein] S-acetyltransferase
2.3.1.39 [acyl-carrier-protein] S-malonyltransferase malonyl-CoA:[acyl-carrier protein] S-malonyltransferase
2.3.1.41 beta-ketoacyl-[acyl-carrier-protein] synthase I acyl-[acyl-carrier protein]:malonyl-[acyl-carrier protein] C-acyltransferase (decarboxylating)
2.3.1.85 fatty-acid synthase system acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)
2.3.3.10 hydroxymethylglutaryl-CoA synthase acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
2.5.1.1 dimethylallyltranstransferase prenyl-diphosphate:3-methylbut-3-en-1-yl-diphosphate prenyltranstransferase
2.5.1.10 (2E,6E)-farnesyl diphosphate synthase geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase
2.5.1.21 squalene synthase (2E,6E)-farnesyl-diphosphate:(2E,6E)-farnesyl-diphosphate farnesyltransferase
2.5.1.29 geranylgeranyl diphosphate synthase (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase
2.7.1.36 mevalonate kinase ATP:(R)-mevalonate 5-phosphotransferase
2.7.4.2 phosphomevalonate kinase ATP:(R)-5-phosphomevalonate phosphotransferase
3.1.2.14 oleoyl-[acyl-carrier-protein] hydrolase oleoyl-[acyl-carrier protein] hydrolase
3.3.2.11 cholesterol-5,6-oxide hydrolase 5,6alpha-epoxy-5alpha-cholestan-3beta-ol hydrolase
4.1.1.33 diphosphomevalonate decarboxylase ATP:(R)-5-diphosphomevalonate carboxy-lyase (adding ATP; isopentenyl-diphosphate-forming)
4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] hydro-lyase (oct-2-enoyl-[acyl-carrier protein]-forming)
5.3.3.2 isopentenyl-diphosphate DELTA-isomerase 3-methylbut-3-en-1-yl-diphosphate DELTA3-DELTA2-isomerase
5.4.99.7 Lanosterol synthase (S)-2,3-Epoxysqualene mutase (cyclizing, lanosterol-forming)
6.4.1.2 acetyl-CoA carboxylase acetyl-CoA:hydrogencarbonate ligase (ADP-forming)


Proteins

Protein ID name full name