Lanosterol biosynthesis

Mitsche MA, McDonald JG, Hobbs HH, Cohen JC. Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways. Elife. 2015 Jun 26;4():e07999. PMID: 26114596; PMCID: PMC4501332.; Faust PL, Kovacs WJ. Cholesterol biosynthesis and ER stress in peroxisome deficiency. Biochimie. 2014 Mar;98():75–85. doi: 10.1016/j.biochi.2013.10.019. PMID: 24211592.; Hogenboom S, Romeijn GJ, Houten SM, Baes M, Wanders RJA, Waterham HR. Absence of functional peroxisomes does not lead to deficiency of enzymes involved in cholesterol biosynthesis. Journal of Lipid Research. 2002 Jan;43(1):90–8. doi: 10.1016/s0022-2275(20)30191-7.

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

(R)-mevalonate

Formula: C6H11O4 (147.0657306)

CAS ID: 1192-42-3

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH) (R)-mevalonate:NADP+ oxidoreductase (CoA-acylating)
2.7.4.2 phosphomevalonate kinase ATP:(R)-5-phosphomevalonate phosphotransferase


Proteins

Protein ID name full name