Phase II - Conjugation of compounds

McCarver DG, Hines RN. The Ontogeny of Human Drug-Metabolizing Enzymes: Phase II Conjugation Enzymes and Regulatory Mechanisms. The Journal of Pharmacology and Experimental Therapeutics. 2002 Feb;300(2):361–6. doi: 10.1124/jpet.300.2.361.

Metabolites

3,4-Dihydroxybenzoate

Formula: C7H6O4 (154.0266076)

CAS ID: 99-50-3

4-Nitrophenol

Formula: C6H5NO3 (139.02694200000002)

CAS ID: 100-02-7

6-Mercaptopurine

Formula: C5H4N4S (152.0156664)

CAS ID: 50-44-2

6-Methylmercaptopurine

Formula: C6H6N4S (166.0313156)

CAS ID: 50-66-8

Acetaminophen

Formula: C8H9NO2 (151.0633254)

CAS ID: 103-90-2

Adenosine

Formula: C10H13N5O4 (267.09674980000005)

CAS ID: 58-61-7

Aromatic acid

Formula: C7H6O2 (122.0367776)

CAS ID: 65-85-0

Aryl sulfate

Formula: C6H6O4S (173.9986796)

CAS ID: 937-34-8

Benzo[a]pyrene-7,8-dione

Formula: C20H10O2 (282.068076)

CAS ID: 65199-11-3

Bilirubin-glucuronoside

Formula: C39H44N4O12 (760.2955584)

CAS ID: 27071-67-6

Cacodylate

Formula: C2H7AsO2 (137.9661982)

CAS ID: 75-60-5

Cholesterol

Formula: C27H46O (386.3548466)

CAS ID: 57-88-5

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Dehydroepiandrosterone

Formula: C19H28O2 (288.2089188)

CAS ID: 53-43-0

Dinitrochlorobenzene

Formula: C6H3ClN2O4 (201.9781348)

CAS ID: 97-00-7

Dopamine 3-O-sulfate

Formula: C8H11NO5S (233.0357916)

CAS ID: 51317-41-0

Estradiol-17beta

Formula: C18H24O2 (272.17762039999997)

CAS ID: 50-28-2

Estrone

Formula: C18H22O2 (270.1619712)

CAS ID: 53-16-7

Estrone 3-sulfate

Formula: C18H22O5S (350.11878820000004)

CAS ID: 481-97-0

Formaldehyde

Formula: CH2O (30.0105642)

CAS ID: 50-00-0

Glutathione

Formula: C10H17N3O6S (307.08380220000004)

CAS ID: 70-18-8

Glycitein

Formula: C16H12O5 (284.0684702)

CAS ID: 40957-83-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydrochloric acid

Formula: HCl (35.9766776)

CAS ID: 7647-01-0

Lithium

Formula: Li (7.016005)

CAS ID: 7439-93-2

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

Mercaptoethanol

Formula: C2H6OS (78.0139346)

CAS ID: 60-24-2

Methanearsonous acid

Formula: CH5AsO2 (123.950549)

CAS ID: 25400-23-1

N-Hydroxy-4-aminobiphenyl

Formula: C12H11NO (185.0840596)

CAS ID: 1204-79-1

N-Methylpyridinium

Formula: C6H8N (94.06567079999999)

CAS ID: 694-56-4

NADP+

Formula: C21H29N7O17P3 (744.0832754)

CAS ID: 53-59-8

NADPH

Formula: C21H30N7O17P3 (745.0911)

CAS ID: 2646-71-1

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Phenol

Formula: C6H6O (94.0418626)

CAS ID: 108-95-2

Phenyl acetate

Formula: C8H8O2 (136.0524268)

CAS ID: 122-79-2

Potassium cation

Formula: K (38.963708)

CAS ID: 24203-36-9

Pregnenolone

Formula: C21H32O2 (316.24021719999996)

CAS ID: 145-13-1

Pyridine

Formula: C5H5N (79.042197)

CAS ID: 110-86-1

S-Formylglutathione

Formula: C11H17N3O7S (335.0787172)

CAS ID: 50409-81-9

Salicyluric acid

Formula: C9H9NO4 (195.0531554)

CAS ID: 487-54-7

Taurolithocholate sulfate

Formula: C26H45NO8S2 (563.258645)

CAS ID: 15324-65-9

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

Triiodothyronine sulfate

Formula: C15H12I3NO7S (730.7468772)

CAS ID: 31135-55-4

4-Nitrophenyl sulfate

Formula: C6H5NO6S (218.983759)

CAS ID: 1080-04-2

2-(Methylthio)ethanol

Formula: C3H8OS (92.0295838)

CAS ID: 5271-38-5

Paracetamol sulfate

Formula: C8H9NO5S (231.0201424)

CAS ID: 10066-90-7

4-Nitrophenyl butyrate

Formula: C10H11NO4 (209.0688046)

CAS ID: 2635-84-9

Salicylates

Formula: C7H5O3 (137.023868)

CAS ID: 63-36-5

formate

Formula: CHO2 (44.997654600000004)

CAS ID: 71-47-6

butyrate

Formula: C4H7O2 (87.0446022)

CAS ID: 461-55-2

mycophenolate

Formula: C17H19O6 (319.1181574)

CAS ID:

dimethylarsinate

Formula: C2H6AsO2 (136.9583736)

CAS ID: 15132-04-4

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

UDP(3-)

Formula: C9H11N2O12P2 (400.9787246)

CAS ID: 86527-70-0

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8

methylarsonate(1-)

Formula: CH4AsO3 (138.9376394)

CAS ID: 51952-66-0



Enzyme

EC Number name full name note
1.11.1.-
1.1.1.19 glucuronate reductase L-gulonate:NADP+ 6-oxidoreductase
1.1.1.2 alcohol dehydrogenase (NADP+) alcohol:NADP+ oxidoreductase
1.1.1.20 glucuronolactone reductase L-gulono-1,4-lactone:NADP+ 1-oxidoreductase
1.1.1.22 UDP-glucose 6-dehydrogenase UDP-alpha-D-glucose:NAD+ 6-oxidoreductase
1.1.1.372 D/L-glyceraldehyde reductase glycerol:NADP+ oxidoreductase (D/L-glyceraldehyde-forming)
1.1.1.54 allyl-alcohol dehydrogenase allyl-alcohol:NADP+ oxidoreductase
1.14.14.1 unspecific monooxygenase substrate,NADPH-hemoprotein reductase:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
1.16.1.8 [methionine synthase] reductase [methionine synthase]-methylcob(III)alamin,S-adenosyl-L-homocysteine:NADP+ oxidoreductase
1.20.4.2 methylarsonate reductase glutathione:methylarsonate oxidoreductase
1.8.5.1 glutathione dehydrogenase (ascorbate) glutathione:dehydroascorbate oxidoreductase
2.1.1.1 nicotinamide N-methyltransferase S-adenosyl-L-methionine:nicotinamide N-methyltransferase
2.1.1.13 methionine synthase 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
2.1.1.137 arsenite methyltransferase S-adenosyl-L-methionine:arsenous acid As-methyltransferase
2.1.1.6 catechol O-methyltransferase S-adenosyl-L-methionine:catechol O-methyltransferase
2.1.1.67 thiopurine S-methyltransferase S-adenosyl-L-methionine:thiopurine S-methyltransferase
2.3.1.118 N-hydroxyarylamine O-acetyltransferase acetyl-CoA:N-hydroxyarylamine O-acetyltransferase
2.3.1.5 arylamine N-acetyltransferase acetyl-CoA:arylamine N-acetyltransferase
2.3.2.2 gamma-glutamyltransferase (5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase
2.4.1.17 glucuronosyltransferase UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)
2.5.1.18 glutathione transferase RX:glutathione R-transferase
2.5.1.6 methionine adenosyltransferase ATP:L-methionine S-adenosyltransferase
2.7.7.9 UTP-glucose-1-phosphate uridylyltransferase UTP:alpha-D-glucose-1-phosphate uridylyltransferase
2.8.2.1 aryl sulfotransferase 3'-phosphoadenylyl-sulfate:phenol sulfotransferase
2.8.2.14 bile-salt sulfotransferase 3'-phosphoadenylyl-sulfate:glycolithocholate sulfotransferase
2.8.2.2 alcohol sulfotransferase 3'-phosphoadenylyl-sulfate:alcohol sulfotransferase
2.8.2.4 estrone sulfotransferase 3'-phosphoadenylyl-sulfate:estrone 3-sulfotransferase
3.1.1.56 methylumbelliferyl-acetate deacetylase 4-methylumbelliferyl-acetate acylhydrolase
3.1.1.93 mycophenolic acid acyl-glucuronide esterase mycophenolic acid O-acyl-glucuronide-ester hydrolase
3.1.2.12 S-formylglutathione hydrolase S-formylglutathione hydrolase
3.1.2.22 palmitoyl[protein] hydrolase palmitoyl[protein] hydrolase
3.1.3.57 inositol-1,4-bisphosphate 1-phosphatase 1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase
3.1.3.7 3'(2'),5'-bisphosphate nucleotidase adenosine-3'(2'),5'-bisphosphate 3'(2')-phosphohydrolase
3.13.2.1 adenosylhomocysteinase S-adenosyl-L-homocysteine hydrolase
3.4.13.18 cytosol nonspecific dipeptidase
3.4.19.13 glutathione gamma-glutamate hydrolase
3.4.19.14 leukotriene-C4 hydrolase
3.5.2.9 5-oxoprolinase (ATP-hydrolysing) 5-oxo-L-proline amidohydrolase (ATP-hydrolysing)
4.1.1.35 UDP-glucuronate decarboxylase UDP-D-glucuronate carboxy-lyase (UDP-D-xylose-forming)
4.2.1.152 hydroperoxy icosatetraenoate dehydratase hydroperoxyicosatetraenoate hydro-lyase (oxoicosatetraenoate-forming)
4.3.2.9 gamma-glutamylcyclotransferase alpha-(gamma-L-glutamyl)-L-amino-acid gamma-glutamyl cyclotransferase (5-oxo-L-proline producing)
4.4.1.20 leukotriene-C4 synthase leukotriene-C4 glutathione-lyase (leukotriene-A4-forming)
5.2.1.2 maleylacetoacetate isomerase 4-maleylacetoacetate cis-trans-isomerase
5.3.99.2 Prostaglandin-D synthase (5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase
6.3.2.2 glutamate-cysteine ligase L-glutamate:L-cysteine gamma-ligase (ADP-forming)
6.3.2.3 glutathione synthase gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)


Proteins

Protein ID name full name