Estrone 3-sulfate (BioCAD00000010741)

blood urine epidermis intestine kidney liver ovary placenta platelet testis

Metabolite Card

Formula: C18H22O5S (350.1188)
SMILES: C[C@]12CC[C@H]3[C@@H](CCC4=C3C=CC(OS(O)(=O)=O)=C4)[C@@H]1CCC2=O

Synonyms [en]

Estrone 3-sulfate; estrone sulfate; Estrone hydrogen sulfate; estrone-3-sulfate; Estrone sulphate; estrone hydrogen sulphate

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

Estrone 3-sulfate. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000010741). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

Estrone sulfate is a sulfated estrone derivative. Estrone sulfate acts as a long-lived reservoir that can be converted as needed to the more active estradiol (from estrone via 17 beta-hydroxysteroid dehydrogenase). Estrone Sulfate (E1S) is the most abundant circulating estrogen in non-pregnant women as well as normal men. Estrone is primarily synthesized from estrone sulfate. Estrone is an estrogenic hormone secreted by the ovaries and adipose tissues. Estrone is one of the three estrogens found in humans. The other two are estriol and estradiol. Estrone is the least prevalent of the three. Estradiol plays a critical role on reproductive and sexual functioning in women and it also affects other organs including the bones. Estriol is an estrogen that is prevalent primarily during pregnancy.

Cytoplasm Extracellular Membrane Endoplasmic reticulum
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 15833-07-5
  • CAS Registry Number: 481-97-0
  • CAS Registry Number: BRD-K51095933-231-03-2
  • PubChem: 3001028
  • PubChem: 699
  • ChEBI: ChEBI:17474
  • HMDB: HMDB0001425
  • HMDB: HMDB01425
  • LipidMaps: LMST02010043
  • KEGG: C02538
  • NCBI MeSH: estrone sulfate
  • Wikipedia: Estrone sulfate
  • Wikipedia: Estrone_sulfate
  • DrugBank: DB04574
  • RefMet: RM0018356
  • MoNA: SM832651
  • Metlin: METLIN_3556
  • Coconut NaturalProduct: CNP0274514.2
  • Coconut NaturalProduct: CNP0345939.3
  • Coconut NaturalProduct: CNP0345939.7

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R02350 2.8.2.4 3'-phosphoadenylylsulfate:estrone 3-sulfotransferase
KEGG:R03980 3.1.6.1 estrone 3-sulfate sulfohydrolase
View More
Organism Source

Taxonomy Source

  1. Homo sapiens [ncbi taxid: 9606]
  2. Mus musculus [ncbi taxid: 10090]

Pathway Synthetic

pathway id name
Reactome:R-BTA-1430728 Metabolism
Reactome:R-CEL-211859 Biological oxidations
Reactome:R-CEL-156584 Cytosolic sulfonation of small molecules
Reactome:R-CFA-1430728 Metabolism
Reactome:R-CFA-156580 Phase II - Conjugation of compounds
Reactome:R-DRE-156584 Cytosolic sulfonation of small molecules
Reactome:R-GGA-156580 Phase II - Conjugation of compounds
Reactome:R-HSA-211859 Biological oxidations
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-211859 Biological oxidations
Reactome:R-XTR-156584 Cytosolic sulfonation of small molecules
Reactome:R-BTA-211859 Biological oxidations
Reactome:R-CFA-156584 Cytosolic sulfonation of small molecules
Reactome:R-GGA-156584 Cytosolic sulfonation of small molecules
Reactome:R-HSA-156580 Phase II - Conjugation of compounds
Reactome:R-MMU-156580 Phase II - Conjugation of compounds
Reactome:R-RNO-211859 Biological oxidations
Reactome:R-SSC-1430728 Metabolism
Reactome:R-SSC-211859 Biological oxidations
Reactome:R-BTA-156584 Cytosolic sulfonation of small molecules
View All Pathways