EC: 5.3.1.8

mannose-6-phosphate isomerase (D-mannose-6-phosphate aldose-ketose-isomerase)

enzyme lambda metabolic reaction experiment
uniprot:P07874 [Co2+]

D_Mannose_6_phosphate -> D_Fructose_6_phosphate		 (( (Vmax * A) ) / (Km + A)) buffer: 50 mM MOPS, 1 mM NADP+, 4 units/ml Phosphoglucose isomerase, 4 units/ml Glucose-6-phosphate dehydrogenase
PH: 7
Temperature: 25
uniprot:Q9FZH5 [mannose-6-phosphate isomerase(Enzyme) wildtype PMI2 His6-tagged]

D_Mannose_6_phosphate -> D_Fructose_6_phosphate		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.5 mM NADP+, 1 U/ml phosphoglucose isomerase, 1 U/ml glucose-6-phosphate dehydrogenase
PH: 7.5
Temperature: 25
uniprot:Q9M884 [mannose-6-phosphate isomerase(Enzyme) wildtype PMI1 His6-tagged]

D_Mannose_6_phosphate -> D_Fructose_6_phosphate		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.5 mM NADP+, 1 U/ml phosphoglucose isomerase, 1 U/ml glucose-6-phosphate dehydrogenase
PH: 7.5
Temperature: 25
uniprot:Q9HIC2 [mannose-6-phosphate isomerase(Enzyme) wildtype]

D_Mannose_6_phosphate -> D_Fructose_6_phosphate		 (( (V * substrate) ) / (Km + substrate)) buffer: 100 mM Tris/HCl, 0.3 mM NADH, 0.6 units mannitol 1-phosphate dehydrogenase, 1 unit PGI
PH: 7.6
Temperature: 50
uniprot:Q9YE01 [mannose-6-phosphate isomerase(Enzyme) wildtype]

D_Mannose_6_phosphate -> D_Fructose_6_phosphate		 (( (V * substrate) ) / (Km + substrate)) buffer: 100 mM Tris/HCl, 0.3 mM NADH, 0.6 units mannitol 1-phosphate dehydrogenase, 1 unit PGI
PH: 7.4
Temperature: 80
uniprot:Q68FX1 [mannose-6-phosphate isomerase(Enzyme) wildtype]

D_Mannose_6_phosphate -> D_Fructose_6_phosphate		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM sodium acetate-HCl, 30 mM KCl
PH: 5.5
Temperature: 37
uniprot:Q8ZWV0 [mannose-6-phosphate isomerase(Enzyme) wildtype]

D_Mannose_6_phosphate -> D_Fructose_6_phosphate		 (( (Vmax * S) ) / (Km + S)) buffer: -
PH: 7.4
Temperature: 80

Pathways

pathway id name
BioCyc:META_PWY-5659 GDP-mannose biosynthesis
BioCyc:META_MANNCAT-PWY D-mannose degradation
BioCyc:YEAST_PWY3O-123 dolichyl phosphate D-mannose biosynthesis
BioCyc:MOUSE_MANNCAT-PWY D-mannose degradation
BioCyc:BSUB_MANNCAT-PWY D-mannose degradation
BioCyc:ECOL316407_COLANSYN-PWY colanic acid building blocks biosynthesis
BioCyc:HUMAN_PWY-5659 GDP-mannose biosynthesis
BioCyc:META_PWY-7323 superpathway of GDP-mannose-derived O-antigen building blocks biosynthesis
BioCyc:ECO_MANNCAT-PWY D-mannose degradation
BioCyc:ECO_PWY-5659 GDP-mannose biosynthesis
BioCyc:YEAST_PWY3O-1743 mannose degradation
BioCyc:YEAST_MANNCAT-PWY D-mannose degradation
BioCyc:MOUSE_COLANSYN-PWY colanic acid building blocks biosynthesis
BioCyc:META_COLANSYN-PWY colanic acid building blocks biosynthesis
BioCyc:ECO_COLANSYN-PWY colanic acid building blocks biosynthesis
BioCyc:YEAST_PWY-5659 GDP-mannose biosynthesis
BioCyc:ARA_MANNCAT-PWY D-mannose degradation
BioCyc:MOUSE_PWY-5659 GDP-mannose biosynthesis
BioCyc:HUMAN_MANNCAT-PWY D-mannose degradation
BioCyc:ARA_PWY-882 L-ascorbate biosynthesis I (L-galactose pathway)
BioCyc:ARA_PWY-5659 GDP-mannose biosynthesis
BioCyc:ARA_PWY-3881 mannitol biosynthesis
BioCyc:MOUSE_MANGDPMET-PWY GDP-mannose metabolism
BioCyc:MOUSE_PWY-5657 GDP-mannose biosynthesis I
BioCyc:MOUSE_PWY-3861 mannitol degradation II
BioCyc:BSUB_PWY-5659 GDP-mannose biosynthesis
BioCyc:ECOL316407_PWY-5659 GDP-mannose biosynthesis
BioCyc:ECOL316407_MANNCAT-PWY D-mannose degradation
PathBank:SMP0000842 Mannose Metabolism
PathBank:SMP0000906 Amino Sugar and Nucleotide Sugar Metabolism II
PathBank:SMP0000967 Colanic Acid Building Blocks Biosynthesis
PlantCyc:ARA_PWY-5659 GDP-mannose biosynthesis
PlantCyc:ARA_PWY-882 L-ascorbate biosynthesis I (L-galactose pathway)
PlantCyc:ARA_PWY-3881 mannitol biosynthesis
PlantCyc:PLANT_PWY-882 L-ascorbate biosynthesis I (L-galactose pathway)
PlantCyc:PLANT_PWY-5659 GDP-mannose biosynthesis
PlantCyc:ARA_MANNCAT-PWY D-mannose degradation
PlantCyc:PLANT_MANNCAT-PWY D-mannose degradation
Reactome:R-BTA-597592 Post-translational protein modification
Reactome:R-CEL-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome:R-CEL-446205 Synthesis of GDP-mannose
Reactome:R-DDI-597592 Post-translational protein modification
Reactome:R-DDI-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome:R-DDI-446205 Synthesis of GDP-mannose
Reactome:R-HSA-392499 Metabolism of proteins
Reactome:R-HSA-597592 Post-translational protein modification
Reactome:R-MMU-446219 Synthesis of substrates in N-glycan biosythesis
Reactome:R-RNO-597592 Post-translational protein modification
Reactome:R-SCE-597592 Post-translational protein modification
Reactome:R-SCE-446219 Synthesis of substrates in N-glycan biosythesis
Reactome:R-SPO-446203 Asparagine N-linked glycosylation
Reactome:R-BTA-446219 Synthesis of substrates in N-glycan biosythesis
Reactome:R-CEL-392499 Metabolism of proteins
Reactome:R-CEL-597592 Post-translational protein modification
Reactome:R-CEL-446203 Asparagine N-linked glycosylation
Reactome:R-DDI-392499 Metabolism of proteins
Reactome:R-DDI-446203 Asparagine N-linked glycosylation
Reactome:R-HSA-446219 Synthesis of substrates in N-glycan biosythesis
Reactome:R-MMU-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome:R-MMU-446205 Synthesis of GDP-mannose
Reactome:R-RNO-392499 Metabolism of proteins
Reactome:R-RNO-446219 Synthesis of substrates in N-glycan biosythesis
Reactome:R-SCE-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome:R-SCE-446205 Synthesis of GDP-mannose
Reactome:R-BTA-392499 Metabolism of proteins
Reactome:R-BTA-446203 Asparagine N-linked glycosylation
Reactome:R-CEL-446219 Synthesis of substrates in N-glycan biosythesis
Reactome:R-DDI-446219 Synthesis of substrates in N-glycan biosythesis
Reactome:R-HSA-446203 Asparagine N-linked glycosylation
Reactome:R-MMU-392499 Metabolism of proteins
Reactome:R-MMU-597592 Post-translational protein modification
Reactome:R-RNO-446203 Asparagine N-linked glycosylation
Reactome:R-SPO-392499 Metabolism of proteins
Reactome:R-SPO-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome:R-SPO-446205 Synthesis of GDP-mannose
Reactome:R-BTA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome:R-BTA-446205 Synthesis of GDP-mannose
Reactome:R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome:R-HSA-446205 Synthesis of GDP-mannose
Reactome:R-MMU-446203 Asparagine N-linked glycosylation
Reactome:R-RNO-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome:R-RNO-446205 Synthesis of GDP-mannose
Reactome:R-SCE-392499 Metabolism of proteins
Reactome:R-SCE-446203 Asparagine N-linked glycosylation
Reactome:R-SPO-597592 Post-translational protein modification
Reactome:R-SPO-446219 Synthesis of substrates in N-glycan biosythesis
WikiPathways:WP4521 Glycosylation and related congenital defects
PathBank:SMP0000064 Fructose and Mannose Degradation
PathBank:SMP0002331 Amino Sugar and Nucleotide Sugar Metabolism
PathBank:SMP0087197 Fructose and Mannose Degradation
PathBank:SMP0000725 Fructose Intolerance, Hereditary
PathBank:SMP0012444 Mannose Metabolism
PathBank:SMP0120844 Fructosuria
PathBank:SMP0120876 Fructose Intolerance, Hereditary
PathBank:SMP0000561 Fructosuria
PathBank:SMP0087296 Fructose and Mannose Degradation
PathBank:SMP0002315 Mannose Metabolism