superpathway of GDP-mannose-derived O-antigen building blocks biosynthesis
Samuel G, Reeves P. Biosynthesis of O-antigens: genes and pathways involved in nucleotide sugar precursor synthesis and O-antigen assembly. Carbohydr Res. 2003 Nov 14;338(23):2503–19. doi: 10.1016/j.carres.2003.07.009. PMID: 14670712.; Andrianopoulos K, Wang L, Reeves PR. Identification of the Fucose Synthetase Gene in the Colanic Acid Gene Cluster of Escherichia coli K-12. J Bacteriol. 1998 Feb 15;180(4):998–1001. doi: 10.1128/jb.180.4.998-1001.1998.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.1.1.135 | GDP-6-deoxy-D-talose 4-dehydrogenase | GDP-6-deoxy-alpha-D-talose:NAD(P)+ 4-oxidoreductase | |
| 2.6.1.102 | GDP-perosamine synthase | GDP-4-amino-4,6-dideoxy-alpha-D-mannose:2-oxoglutarate aminotransferase | |
| 2.7.7.13 | mannose-1-phosphate guanylyltransferase | GTP:alpha-D-mannose-1-phosphate guanylyltransferase | |
| 4.2.1.47 | GDP-mannose 4,6-dehydratase | GDP-mannose 4,6-hydro-lyase (GDP-4-dehydro-6-deoxy-D-mannose-forming) | |
| 5.3.1.8 | mannose-6-phosphate isomerase | D-mannose-6-phosphate aldose-ketose-isomerase | |
| 5.3.1.9 | glucose-6-phosphate isomerase | alpha-D-glucose-6-phosphate aldose-ketose-isomerase (configuration-inverting) | |
| 5.4.2.2 | phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) | alpha-D-glucose 1,6-phosphomutase | |
| 5.4.2.8 | phosphomannomutase | alpha-D-mannose 1,6-phosphomutase |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P00946 | manA | Mannose-6-phosphate isomerase |
| P07874 | algA | phosphomannose isomerase / guanosine 5'-diphospho-D-mannose pyrophosphorylase |
| P0A6T1 | pgi | Glucose-6-phosphate isomerase |
| P0AC88 | gmd | GDP-mannose 4,6-dehydratase |
| P24174 | manC | Mannose-1-phosphate guanylyltransferase |
| P24175 | manB | Phosphomannomutase |
| P26276 | algC | phosphomannomutase AlgC |
| Q06952 | gmd | GDP-mannose 4,6-dehydratase |
| Q06953 | rfbE | GDP-perosamine synthase |
| Q51366 | gmd | GDP-mannose 4,6-dehydratase |
| Q9JRN5 | gmd | GDP-mannose 4,6-dehydratase |
| Q9JRN7 | tld | GDP-6-deoxy-D-talose 4-dehydrogenase |