EC: 1.11.1.12

phospholipid-hydroperoxide glutathione peroxidase (glutathione:lipid-hydroperoxide oxidoreductase)

enzyme lambda metabolic reaction experiment
uniprot:P36969 [phospholipid-hydroperoxide glutathione peroxidase(Enzyme) wildtype]

(beta_(13_Hydroperoxy_cis_9,_trans_11_octadecadienoyl)_gamma_palmitoyl)_L_alpha_phosphatidylcholine + 2 Reduced_glutathione -> 2 H2O + Unknown + Oxidized_glutathione		 (( (Vmax * A) ) / (Km + A)) buffer: 0.1 M Tris, 5 mM EDTA, 0.15 mM NADPH, 3.0 U/ml Glutathione reductase, 0.1% Triton X-100
PH: 7.6
Temperature: 37
uniprot:P36969 [phospholipid-hydroperoxide glutathione peroxidase(Enzyme) wildtype]

2 Reduced_glutathione + (beta_(13_Hydroperoxy_cis_9,_trans_11_octadecadienoyl)_gamma_palmitoyl)_L_alpha_phosphatidylcholine -> Oxidized_glutathione + 2 H2O + Unknown		 (( (Vmax * A) ) / (Km + A)) buffer: 0.1 M Tris, 5 mM EDTA, 0.15 mM NADPH, 3.0 U/ml Glutathione reductase, 0.1% Triton X-100
PH: 7.6
Temperature: 37

Pathways

pathway id name
BioCyc:META_PWY-4081 glutathione-peroxide redox reactions
BioCyc:ARA_PWY-4081 glutathione-peroxide redox reactions
BioCyc:MOUSE_PWY-4081 glutathione redox reactions I
BioCyc:HUMAN_DETOX1-PWY-1 reactive oxygen species degradation
BioCyc:HUMAN_PWY-4081 glutathione redox reactions I
BioCyc:META_DETOX1-PWY-1 reactive oxygen species degradation
PlantCyc:ARA_PWY-4081 glutathione-peroxide redox reactions
Reactome:R-RNO-9711123 Cellular response to chemical stress
Reactome:R-BTA-9711123 Cellular response to chemical stress
Reactome:R-MMU-9711123 Cellular response to chemical stress
Reactome:R-HSA-9711123 Cellular response to chemical stress
Reactome:R-BTA-1430728 Metabolism
Reactome:R-BTA-556833 Metabolism of lipids
Reactome:R-BTA-9018896 Biosynthesis of E-series 18(S)-resolvins
Reactome:R-BTA-9020265 Biosynthesis of aspirin-triggered D-series resolvins
Reactome:R-BTA-8953897 Cellular responses to stimuli
Reactome:R-BTA-2262752 Cellular responses to stress
Reactome:R-HSA-74160 Gene expression (Transcription)
Reactome:R-HSA-73857 RNA Polymerase II Transcription
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-556833 Metabolism of lipids
Reactome:R-MMU-9018679 Biosynthesis of EPA-derived SPMs
Reactome:R-MMU-9018676 Biosynthesis of D-series resolvins
Reactome:R-MMU-3299685 Detoxification of Reactive Oxygen Species
Reactome:R-MMU-74160 Gene expression (Transcription)
Reactome:R-MMU-73857 RNA Polymerase II Transcription
Reactome:R-MMU-3700989 Transcriptional Regulation by TP53
Reactome:R-RNO-9018677 Biosynthesis of DHA-derived SPMs
Reactome:R-SSC-9018677 Biosynthesis of DHA-derived SPMs
Reactome:R-BTA-9018679 Biosynthesis of EPA-derived SPMs
Reactome:R-BTA-9018676 Biosynthesis of D-series resolvins
Reactome:R-HSA-2262752 Cellular responses to stress
Reactome:R-MMU-9018677 Biosynthesis of DHA-derived SPMs
Reactome:R-RNO-9018678 Biosynthesis of specialized proresolving mediators (SPMs)
Reactome:R-RNO-9023661 Biosynthesis of E-series 18(R)-resolvins
Reactome:R-RNO-8953897 Cellular responses to stimuli
Reactome:R-RNO-2262752 Cellular responses to stress
Reactome:R-SSC-1430728 Metabolism
Reactome:R-SSC-556833 Metabolism of lipids
Reactome:R-SSC-9018678 Biosynthesis of specialized proresolving mediators (SPMs)
Reactome:R-SSC-9023661 Biosynthesis of E-series 18(R)-resolvins
Reactome:R-BTA-9018678 Biosynthesis of specialized proresolving mediators (SPMs)
Reactome:R-BTA-9023661 Biosynthesis of E-series 18(R)-resolvins
Reactome:R-HSA-3299685 Detoxification of Reactive Oxygen Species
Reactome:R-HSA-212436 Generic Transcription Pathway
Reactome:R-HSA-3700989 Transcriptional Regulation by TP53
Reactome:R-MMU-9018896 Biosynthesis of E-series 18(S)-resolvins
Reactome:R-MMU-9020265 Biosynthesis of aspirin-triggered D-series resolvins
Reactome:R-MMU-212436 Generic Transcription Pathway
Reactome:R-MMU-5628897 TP53 Regulates Metabolic Genes
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-556833 Metabolism of lipids
Reactome:R-RNO-9018679 Biosynthesis of EPA-derived SPMs
Reactome:R-RNO-9018676 Biosynthesis of D-series resolvins
Reactome:R-RNO-74160 Gene expression (Transcription)
Reactome:R-RNO-73857 RNA Polymerase II Transcription
Reactome:R-RNO-3700989 Transcriptional Regulation by TP53
Reactome:R-RNO-3299685 Detoxification of Reactive Oxygen Species
Reactome:R-SSC-9018679 Biosynthesis of EPA-derived SPMs
Reactome:R-SSC-9018676 Biosynthesis of D-series resolvins
Reactome:R-BTA-9018677 Biosynthesis of DHA-derived SPMs
Reactome:R-BTA-3299685 Detoxification of Reactive Oxygen Species
Reactome:R-HSA-8953897 Cellular responses to stimuli
Reactome:R-HSA-5628897 TP53 Regulates Metabolic Genes
Reactome:R-MMU-9018678 Biosynthesis of specialized proresolving mediators (SPMs)
Reactome:R-MMU-9023661 Biosynthesis of E-series 18(R)-resolvins
Reactome:R-MMU-8953897 Cellular responses to stimuli
Reactome:R-MMU-2262752 Cellular responses to stress
Reactome:R-RNO-9018896 Biosynthesis of E-series 18(S)-resolvins
Reactome:R-RNO-9020265 Biosynthesis of aspirin-triggered D-series resolvins
Reactome:R-RNO-212436 Generic Transcription Pathway
Reactome:R-RNO-5628897 TP53 Regulates Metabolic Genes
Reactome:R-SSC-9018896 Biosynthesis of E-series 18(S)-resolvins
Reactome:R-SSC-9020265 Biosynthesis of aspirin-triggered D-series resolvins
PathBank:SMP0120480 gamma-Glutamyltransferase Deficiency
PathBank:SMP0120565 5-Oxoprolinase Deficiency
PathBank:SMP0000015 Glutathione Metabolism
PathBank:SMP0000083 Acetylsalicylic Acid Action Pathway
PathBank:SMP0000087 Rofecoxib Action Pathway
PathBank:SMP0000094 Sulindac Action Pathway
PathBank:SMP0000104 Indomethacin Action Pathway
PathBank:SMP0000120 Naproxen Action Pathway
PathBank:SMP0000106 Meloxicam Action Pathway
PathBank:SMP0000500 5-Oxoprolinase Deficiency
PathBank:SMP0000693 Antrafenine Action Pathway
PathBank:SMP0000697 Flurbiprofen Action Pathway
PathBank:SMP0000701 Phenylbutazone Action Pathway
PathBank:SMP0000705 Tiaprofenic Acid Action Pathway
PathBank:SMP0000709 Salicylic Acid Action Pathway
PathBank:SMP0000075 Arachidonic Acid Metabolism
PathBank:SMP0000086 Ibuprofen Action Pathway
PathBank:SMP0000093 Diclofenac Action Pathway
PathBank:SMP0000098 Ketorolac Action Pathway
PathBank:SMP0000102 Bromfenac Action Pathway
PathBank:SMP0000114 Nabumetone Action Pathway
PathBank:SMP0000692 Antipyrine Action Pathway
PathBank:SMP0000696 Fenoprofen Action Pathway
PathBank:SMP0000700 Lornoxicam Action Pathway
PathBank:SMP0000704 Tolmetin Action Pathway
PathBank:SMP0000708 Salicylate-Sodium Action Pathway
PathBank:SMP0063595 Arachidonic Acid Metabolism
PathBank:SMP0120485 Glutathione Synthetase Deficiency
PathBank:SMP0120566 gamma-Glutamyltranspeptidase Deficiency
PathBank:SMP0000337 Glutathione Synthetase Deficiency
PathBank:SMP0000077 Piroxicam Action Pathway
PathBank:SMP0000084 Etodolac Action Pathway
PathBank:SMP0000109 Mefenamic Acid Action Pathway
PathBank:SMP0000289 Diflunisal Action Pathway
PathBank:SMP0000116 Valdecoxib Action Pathway
PathBank:SMP0000501 gamma-Glutamyltranspeptidase Deficiency
PathBank:SMP0000694 Carprofen Action Pathway
PathBank:SMP0000698 Magnesium Salicylate Action Pathway
PathBank:SMP0000702 Nepafenac Action Pathway
PathBank:SMP0000706 Tenoxicam Action Pathway
PathBank:SMP0000710 Acetaminophen Action Pathway
PathBank:SMP0120446 5-Oxoprolinuria
PathBank:SMP0120510 Leukotriene C4 Synthesis Deficiency
PathBank:SMP0000143 5-Oxoprolinuria
PathBank:SMP0000183 gamma-Glutamyltransferase Deficiency
PathBank:SMP0000353 Leukotriene C4 Synthesis Deficiency
PathBank:SMP0000085 Ketoprofen Action Pathway
PathBank:SMP0000096 Celecoxib Action Pathway
PathBank:SMP0000101 Suprofen Action Pathway
PathBank:SMP0000113 Oxaprozin Action Pathway
PathBank:SMP0000695 Etoricoxib Action Pathway
PathBank:SMP0000699 Lumiracoxib Action Pathway
PathBank:SMP0000703 Trisalicylate-Choline Action Pathway
PathBank:SMP0000707 Salsalate Action Pathway
PathBank:SMP0063622 Glutathione Metabolism