Biosynthesis of E-series 18(R)-resolvins
Calder PC. Omega-3 fatty acids and inflammatory processes: from molecules to man. Biochem Soc Trans. 2017 Oct 15;45(5):1105–15. doi: 10.1042/bst20160474. PMID: 28900017.; Molfino A, Amabile MI, Monti M, Muscaritoli M. Omega-3 Polyunsaturated Fatty Acids in Critical Illness: Anti-Inflammatory, Proresolving, or Both? Oxidative Medicine and Cellular Longevity. 2017 Jan;2017(1). doi: 10.1155/2017/5987082.; Kyriakopoulos AM, Nagl M, Baliou S, Zoumpourlis V. Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory Drugs. International Journal of Inflammation. 2017;2017():1–17. doi: 10.1155/2017/9632018.; Serhan CN, Petasis NA. Resolvins and protectins in inflammation resolution. Chem Rev. 2011 Oct 12;111(10):5922–43. PMID: 21766791; PMCID: PMC3192290.; Arita M, Clish CB, Serhan CN. The contributions of aspirin and microbial oxygenase to the biosynthesis of anti-inflammatory resolvins: Novel oxygenase products from ?-3 polyunsaturated fatty acids. Biochemical and Biophysical Research Communications. 2005 Dec;338(1):149–57. doi: 10.1016/j.bbrc.2005.07.181.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.13.11.- | |||
| 1.11.1.12 | phospholipid-hydroperoxide glutathione peroxidase | glutathione:lipid-hydroperoxide oxidoreductase | |
| 1.11.1.9 | glutathione peroxidase | glutathione:hydrogen-peroxide oxidoreductase | |
| 1.13.11.12 | linoleate 13S-lipoxygenase | linoleate:oxygen 13-oxidoreductase | |
| 1.13.11.31 | arachidonate 12-lipoxygenase | arachidonate:oxygen 12-oxidoreductase | |
| 1.13.11.33 | arachidonate 15-lipoxygenase | arachidonate:oxygen 15-oxidoreductase |
Proteins
| Protein ID | name | full name |
|---|