Biosynthesis of E-series 18(R)-resolvins

Calder PC. Omega-3 fatty acids and inflammatory processes: from molecules to man. Biochem Soc Trans. 2017 Oct 15;45(5):1105–15. doi: 10.1042/bst20160474. PMID: 28900017.; Molfino A, Amabile MI, Monti M, Muscaritoli M. Omega-3 Polyunsaturated Fatty Acids in Critical Illness: Anti-Inflammatory, Proresolving, or Both? Oxidative Medicine and Cellular Longevity. 2017 Jan;2017(1). doi: 10.1155/2017/5987082.; Kyriakopoulos AM, Nagl M, Baliou S, Zoumpourlis V. Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory Drugs. International Journal of Inflammation. 2017;2017():1–17. doi: 10.1155/2017/9632018.; Serhan CN, Petasis NA. Resolvins and protectins in inflammation resolution. Chem Rev. 2011 Oct 12;111(10):5922–43. PMID: 21766791; PMCID: PMC3192290.; Arita M, Clish CB, Serhan CN. The contributions of aspirin and microbial oxygenase to the biosynthesis of anti-inflammatory resolvins: Novel oxygenase products from ?-3 polyunsaturated fatty acids. Biochemical and Biophysical Research Communications. 2005 Dec;338(1):149–57. doi: 10.1016/j.bbrc.2005.07.181.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

18R-HpEPE

Formula: C20H30O4 (334.214398)

CAS ID:



Enzyme

EC Number name full name note
1.13.11.-
1.11.1.12 phospholipid-hydroperoxide glutathione peroxidase glutathione:lipid-hydroperoxide oxidoreductase
1.11.1.9 glutathione peroxidase glutathione:hydrogen-peroxide oxidoreductase
1.13.11.12 linoleate 13S-lipoxygenase linoleate:oxygen 13-oxidoreductase
1.13.11.31 arachidonate 12-lipoxygenase arachidonate:oxygen 12-oxidoreductase
1.13.11.33 arachidonate 15-lipoxygenase arachidonate:oxygen 15-oxidoreductase


Proteins

Protein ID name full name