Cellular response to chemical stress

Sampadi B, Pines A, Munk S, Mišovic B, de Groot AJ, van de Water B, Olsen JV, Mullenders LHF, Vrieling H. Quantitative phosphoproteomics to unravel the cellular response to chemical stressors with different modes of action. Archives of Toxicology. 2020 Mar 18;94(5):1655–71. doi: 10.1007/s00204-020-02712-7.; Tarnow P, Tralau T, Luch A. Chemical activation of estrogen and aryl hydrocarbon receptor signaling pathways and their interaction in toxicology and metabolism. Expert Opinion on Drug Metabolism & Toxicology. 2019 Jan 27;15(3):219–29. doi: 10.1080/17425255.2019.1569627.; Moldogazieva NT, Lutsenko SV, Terentiev AA. Reactive Oxygen and Nitrogen Species-Induced Protein Modifications: Implication in Carcinogenesis and Anticancer Therapy. Cancer Res. 2018 Nov 01;78(21):6040–7. doi: 10.1158/0008-5472.can-18-0980. PMID: 30327380.; Vesela E, Chroma K, Turi Z, Mistrik M. Common Chemical Inductors of Replication Stress: Focus on Cell-Based Studies. Biomolecules. 2017 Feb 21;7(1). PMID: 28230817; PMCID: PMC5372731.; Origassa CS, Câmara NO. Cytoprotective role of heme oxygenase-1 and heme degradation derived end products in liver injury. World J Hepatol. 2013 Oct 27;5(10):541–9. PMID: 24179613; PMCID: PMC3812456.; Wiesinger M, Mayer B, Jennings P, Lukas A. Comparative analysis of perturbed molecular pathways identified in in vitro and in vivo toxicology studies. Toxicol In Vitro. 2012 Sep;26(6):956–62. doi: 10.1016/j.tiv.2012.03.018. PMID: 22515967.; Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB. Oxidative stress, inflammation, and cancer: How are they linked? Free Radical Biology and Medicine. 2010 Dec;49(11):1603–16. doi: 10.1016/j.freeradbiomed.2010.09.006.; Ryter SW, Alam J, Choi AM. Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol Rev. 2006 Apr;86(2):583–650. doi: 10.1152/physrev.00011.2005. PMID: 16601269.

Metabolites

CO

Formula: CO (27.994915)

CAS ID: 630-08-0

Copper

Formula: Cu (62.929599)

CAS ID: 7440-50-8

Cu+

Formula: Cu (62.929599)

CAS ID: 17493-86-6

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

Glutathione

Formula: C10H17N3O6S (307.08380220000004)

CAS ID: 70-18-8

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

HO-

Formula: OH (17.0027396)

CAS ID: 14280-30-9

Hydrogen peroxide

Formula: H2O2 (34.0054792)

CAS ID: 7722-84-1

Hydroxyl radical

Formula: OH (17.0027396)

CAS ID: 3352-57-6

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Superoxide

Formula: O2 (31.98983)

CAS ID: 11062-77-4

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

biliverdin(2-)

Formula: C33H32N4O6 (580.2321732)

CAS ID: 114-25-0

nitrite

Formula: NO2 (45.992904)

CAS ID: 14797-65-0

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.6.3.-
1.11.1.12 phospholipid-hydroperoxide glutathione peroxidase glutathione:lipid-hydroperoxide oxidoreductase
1.11.1.2 NADPH peroxidase NADPH:hydrogen-peroxide oxidoreductase
1.11.1.24 thioredoxin-dependent peroxiredoxin thioredoxin:hydroperoxide oxidoreductase
1.11.1.27 glutathione-dependent peroxiredoxin glutathione:hydroperoxide oxidoreductase
1.11.1.6 catalase hydrogen-peroxide:hydrogen-peroxide oxidoreductase
1.11.1.9 glutathione peroxidase glutathione:hydrogen-peroxide oxidoreductase
1.14.14.18 heme oxygenase (biliverdin-producing) protoheme,NADPH-hemoprotein reductase:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)
1.15.1.1 superoxide dismutase superoxide:superoxide oxidoreductase
1.6.3.1 NAD(P)H oxidase (H2O2-forming) NAD(P)H:oxygen oxidoreductase (H2O2-forming)
1.8.1.7 glutathione-disulfide reductase glutathione:NADP+ oxidoreductase
1.8.1.9 thioredoxin-disulfide reductase thioredoxin:NADP+ oxidoreductase
1.8.3.2 thiol oxidase thiol:oxygen oxidoreductase
1.8.98.2 sulfiredoxin peroxiredoxin-(S-hydroxy-S-oxocysteine):thiol oxidoreductase [ATP-hydrolysing; peroxiredoxin-(S-hydroxycysteine)-forming]
2.3.1.23 1-acylglycerophosphocholine O-acyltransferase acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
2.3.2.32 cullin-RING-type E3 NEDD8 transferase [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine:[cullin] [NEDD8-protein] transferase (isopeptide bond-forming; RING-type)
2.5.1.18 glutathione transferase RX:glutathione R-transferase
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.13 protein kinase C ATP:protein phosphotransferase (diacylglycerol-dependent)
2.7.11.26 tau-protein kinase ATP:[tau-protein] O-phosphotransferase
2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase ATP:[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphotransferase
3.1.1.4 phospholipase A2 phosphatidylcholine 2-acylhydrolase
3.6.1.17 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase
3.6.4.6 vesicle-fusing ATPase ATP phosphohydrolase (vesicle-fusing)
5.3.4.1 protein disulfide-isomerase Protein disulfide-isomerase
7.6.2.2 ABC-type xenobiotic transporter ATP phosphohydrolase (ABC-type, xenobiotic-exporting)
7.6.2.3 ABC-type glutathione-S-conjugate transporter ATP + H2O + glutathione-S-conjugate[side 1] = ADP + phosphate + glutathione-S-conjugate[side 2]


Proteins

Protein ID name full name