Biosynthesis of aspirin-triggered D-series resolvins

Serhan CN, Chiang N, Dalli J, Levy BD. Lipid mediators in the resolution of inflammation. Cold Spring Harb Perspect Biol. 2014 Oct 30;7(2):a016311. PMID: 25359497; PMCID: PMC4315926.; Bannenberg G, Serhan CN. Specialized pro-resolving lipid mediators in the inflammatory response: An update. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2010 Dec;1801(12):1260–73. doi: 10.1016/j.bbalip.2010.08.002.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

17R-HpDHA

Formula: C22H32O4 (360.2300472)

CAS ID:

7S,8S-epoxy-17R-HDHA

Formula: C22H30O4 (358.214398)

CAS ID:

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.11.1.12 phospholipid-hydroperoxide glutathione peroxidase glutathione:lipid-hydroperoxide oxidoreductase
1.11.1.9 glutathione peroxidase glutathione:hydrogen-peroxide oxidoreductase
3.3.2.6 leukotriene-A4 hydrolase (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase
3.4.11.4 tripeptide aminopeptidase


Proteins

Protein ID name full name