EC: 2.5.1.21

squalene synthase ((2E,6E)-farnesyl-diphosphate:(2E,6E)-farnesyl-diphosphate farnesyltransferase)

enzyme lambda metabolic reaction experiment
uniprot:P37268 [squalene synthase(Enzyme) wildtype]

NADPH + 2 trans,trans_Farnesyl_diphosphate + H+ -> 2 Diphosphate + Squalene + NADP+		 (( (Vmax * A) ) / (Km + A)) buffer: 100 mM potassium phosphate, 5.0 mM MgCl2, 5.0 mM CHAPS, 10 mM DTT
PH: 7.4
Temperature: 37
uniprot:P37268 [squalene synthase(Enzyme) wildtype]

H+ + NADPH + 2 trans,trans_Farnesyl_diphosphate -> 2 Diphosphate + NADP+ + Squalene		 (( (Vmax * A) ) / (Km + A)) buffer: 100 mM potassium phosphate, 5.0 mM MgCl2, 5.0 mM CHAPS, 10 mM DTT
PH: 7.4
Temperature: 37

Pathways

pathway id name
BioCyc:YEAST_PWY-5670 epoxysqualene biosynthesis
BioCyc:MOUSE_PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
BioCyc:MOUSE_PWY-5670 epoxysqualene biosynthesis
BioCyc:HUMAN_PWY66-5 superpathway of cholesterol biosynthesis
BioCyc:HUMAN_PWY66-341 cholesterol biosynthesis I
BioCyc:META_PWY-5670 epoxysqualene biosynthesis
BioCyc:META_PWY66-341 cholesterol biosynthesis I
BioCyc:META_PWY66-4 cholesterol biosynthesis III (via desmosterol)
BioCyc:YEAST_ERGOSTEROL-SYN-PWY superpathway of ergosterol biosynthesis
BioCyc:ARA_PWY-2541 plant sterol biosynthesis
BioCyc:MOUSE_PWY66-341 cholesterol biosynthesis I
BioCyc:HUMAN_PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
BioCyc:HUMAN_PWY-5670 epoxysqualene biosynthesis
BioCyc:META_PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
BioCyc:ARA_PWY-5670 epoxysqualene biosynthesis
BioCyc:ARA_PWY-6663 plant sterol biosynthesis II
BioCyc:HUMAN_PWY66-4 cholesterol biosynthesis III (via desmosterol)
BioCyc:META_ERGOSTEROL-SYN-PWY superpathway of ergosterol biosynthesis I
BioCyc:META_PWY66-5 superpathway of cholesterol biosynthesis
BioCyc:META_PWY-2541 plant sterol biosynthesis
BioCyc:META_PWY-6105 botryococcenes and methylated squalene biosynthesis
BioCyc:MOUSE_PWY66-4 cholesterol biosynthesis III (via desmosterol)
Reactome:R-HSA-9969896 Lanosterol biosynthesis
Reactome:R-MMU-9969896 Lanosterol biosynthesis
Reactome:R-SPO-9969896 Lanosterol biosynthesis
Reactome:R-DDI-9969896 Lanosterol biosynthesis
Reactome:R-RNO-9969896 Lanosterol biosynthesis
Reactome:R-SCE-9969896 Lanosterol biosynthesis
Reactome:R-DDI-191273 Cholesterol biosynthesis
Reactome:R-HSA-400206 Regulation of lipid metabolism by PPARalpha
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-556833 Metabolism of lipids
Reactome:R-MMU-8957322 Metabolism of steroids
Reactome:R-SCE-8957322 Metabolism of steroids
Reactome:R-SPO-1430728 Metabolism
Reactome:R-DDI-8957322 Metabolism of steroids
Reactome:R-HSA-556833 Metabolism of lipids
Reactome:R-HSA-191273 Cholesterol biosynthesis
Reactome:R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
Reactome:R-SCE-1430728 Metabolism
Reactome:R-HSA-1989781 PPARA activates gene expression
Reactome:R-MMU-191273 Cholesterol biosynthesis
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-556833 Metabolism of lipids
Reactome:R-RNO-8957322 Metabolism of steroids
Reactome:R-SCE-556833 Metabolism of lipids
Reactome:R-SCE-191273 Cholesterol biosynthesis
Reactome:R-SPO-8957322 Metabolism of steroids
Reactome:R-DDI-1430728 Metabolism
Reactome:R-DDI-556833 Metabolism of lipids
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-8957322 Metabolism of steroids
Reactome:R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)
Reactome:R-RNO-191273 Cholesterol biosynthesis
Reactome:R-SPO-556833 Metabolism of lipids
Reactome:R-SPO-191273 Cholesterol biosynthesis
WikiPathways:WP4190 Mevalonate arm of cholesterol biosynthesis pathway
PathBank:SMP0120794 Mevalonic Aciduria
PathBank:SMP0121207 Triterpenoid Biosynthesis
PathBank:SMP0000023 Steroid Biosynthesis
PathBank:SMP0000387 CHILD Syndrome
PathBank:SMP0000112 Risedronate Action Pathway
PathBank:SMP0000508 Cholesteryl Ester Storage Disease
PathBank:SMP0002438 Cholesterol Biosynthesis and Metabolism CE(12:0)
PathBank:SMP0087326 Steroid Biosynthesis
PathBank:SMP0012042 Epoxysqualene Biosynthesis
PathBank:SMP0120685 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2)
PathBank:SMP0120769 Hypercholesterolemia
PathBank:SMP0120793 Hyper-IgD Syndrome
PathBank:SMP0121055 Mevalonate Pathway
PathBank:SMP0000389 Smith-Lemli-Opitz Syndrome (SLOS)
PathBank:SMP0000319 Lysosomal Acid Lipase Deficiency (Wolman Disease)
PathBank:SMP0000082 Simvastatin Action Pathway
PathBank:SMP0000111 Cerivastatin Action Pathway
PathBank:SMP0000131 Atorvastatin Action Pathway
PathBank:SMP0000511 Wolman Disease
PathBank:SMP0002381 Steroid Biosynthesis
PathBank:SMP0002436 Cholesterol biosynthesis and metabolism CE(10:0)
PathBank:SMP0002441 Cholesterol biosynthesis and metabolism CE(18:0)
PathBank:SMP0087233 Steroid Biosynthesis
PathBank:SMP0120684 CHILD Syndrome
PathBank:SMP0120692 Desmosterolosis
PathBank:SMP0120732 Lysosomal Acid Lipase Deficiency (Wolman Disease)
PathBank:SMP0120792 Cholesteryl Ester Storage Disease
PathBank:SMP0070041 Cholesterol Biosynthesis and Metabolism
PathBank:SMP0000386 Desmosterolosis
PathBank:SMP0000089 Pravastatin Action Pathway
PathBank:SMP0000095 Alendronate Action Pathway
PathBank:SMP0000099 Lovastatin Action Pathway
PathBank:SMP0000117 Pamidronate Action Pathway
PathBank:SMP0000509 Hyper-IgD Syndrome
PathBank:SMP0120735 Smith-Lemli-Opitz Syndrome (SLOS)
PathBank:SMP0120795 Wolman Disease
PathBank:SMP0121205 Sesquiterpenoid Biosynthesis
PathBank:SMP0121236 Steroid Biosynthesis
PathBank:SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2)
PathBank:SMP0000079 Ibandronate Action Pathway
PathBank:SMP0000092 Rosuvastatin Action Pathway
PathBank:SMP0000209 Hypercholesterolemia
PathBank:SMP0000107 Zoledronate Action Pathway
PathBank:SMP0000119 Fluvastatin Action Pathway
PathBank:SMP0000510 Mevalonic Aciduria
PathBank:SMP0002435 Cholesterol biosynthesis and metabolism CE(14:0)
PathBank:SMP0002440 Cholesterol Biosynthesis and Metabolism CE(16:0)