Regulation of lipid metabolism by PPARalpha

Kersten S. Peroxisome proliferator activated receptors and lipoprotein metabolism. PPAR Res. 2008;2008():132960. PMID: 18288277; PMCID: PMC2220040.; Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W. From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions. Prog Lipid Res. 2006 Mar;45(2):120–59. doi: 10.1016/j.plipres.2005.12.002. PMID: 16476485.; Gouni-Berthold I, Krone W. Peroxisome proliferator-activated receptor alpha (PPARalpha) and athero-sclerosis. Curr Drug Targets Cardiovasc Haematol Disord. 2005 Dec;5(6):513–23. doi: 10.2174/156800605774962022. PMID: 16503871.; Desvergne B, Wahli W. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev. 1999 Oct;20(5):649–88. doi: 10.1210/edrv.20.5.0380. PMID: 10529898.

Metabolites

2,3,7,8-Tetrachlorodibenzodioxin

Formula: C12H4Cl4O2 (319.8965404)

CAS ID: 1746-01-6



Enzyme

EC Number name full name note
2.3.1.-
1.1.1.40 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)
1.11.1.2 NADPH peroxidase NADPH:hydrogen-peroxide oxidoreductase
1.14.14.1 unspecific monooxygenase substrate,NADPH-hemoprotein reductase:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
1.14.14.23 cholesterol 7alpha-monooxygenase cholesterol,NADPH-hemoprotein reductase:oxygen oxidoreductase (7alpha-hydroxylating)
1.14.14.26 24-hydroxycholesterol 7alpha-hydroxylase (24R)-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)
1.14.14.80 long-chain fatty acid omega-monooxygenase long-chain fatty acid,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (omega-hydroxylating)
1.14.19.44 acyl-CoA (8-3)-desaturase DELTA8-acyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (5,6-cis-dehydrogenating)
1.3.8.7 medium-chain acyl-CoA dehydrogenase medium-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
1.8.1.9 thioredoxin-disulfide reductase thioredoxin:NADP+ oxidoreductase
2.3.1.21 carnitine O-palmitoyltransferase palmitoyl-CoA:L-carnitine O-palmitoyltransferase
2.3.1.37 5-aminolevulinate synthase succinyl-CoA:glycine C-succinyltransferase (decarboxylating)
2.3.1.48 histone acetyltransferase acetyl-CoA:[protein]-L-lysine acetyltransferase
2.3.3.10 hydroxymethylglutaryl-CoA synthase acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
2.4.1.17 glucuronosyltransferase UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)
2.5.1.21 squalene synthase (2E,6E)-farnesyl-diphosphate:(2E,6E)-farnesyl-diphosphate farnesyltransferase
2.7.11.22 cyclin-dependent kinase ATP:cyclin phosphotransferase
2.7.11.23 [RNA-polymerase]-subunit kinase ATP:[DNA-directed RNA polymerase] phosphotransferase
2.8.2.14 bile-salt sulfotransferase 3'-phosphoadenylyl-sulfate:glycolithocholate sulfotransferase
2.8.2.2 alcohol sulfotransferase 3'-phosphoadenylyl-sulfate:alcohol sulfotransferase
3.1.13.1 exoribonuclease II
3.5.1.98 histone deacetylase histone amidohydrolase
3.6.4.13 RNA helicase
4.2.1.152 hydroperoxy icosatetraenoate dehydratase hydroperoxyicosatetraenoate hydro-lyase (oxoicosatetraenoate-forming)
6.2.1.15 arachidonate-CoA ligase arachidonate:CoA ligase (AMP-forming)
6.2.1.24 phytanate-CoA ligase phytanate:CoA ligase (AMP-forming)
6.2.1.3 long-chain-fatty-acid-CoA ligase long-chain fatty acid:CoA ligase (AMP-forming)
7.6.2.1 P-type phospholipid transporter ATP phosphohydrolase (P-type, phospholipid-flipping)


Proteins

Protein ID name full name