EC: 1.3.8.4

isovaleryl-CoA dehydrogenase (3-methylbutanoyl-CoA:electron-transfer flavoprotein oxidoreductase)

enzyme lambda metabolic reaction experiment
uniprot:Q9FS87 [isovaleryl-CoA dehydrogenase(Enzyme) wildtype]

Electron_transferring_flavoprotein + 3_Methylbutanoyl_CoA -> CO2 + 3_Methylcrotonyl_CoA + Reduced_electron_transferring_flavoprotein		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM HEPES KOH, 1 mM KCN, 1 mM salicylhydroxamic acid, 50 µM FAD, 100 µg/ml phenazine methosulfate
PH: 8
Temperature: 30
uniprot:Q9FS87 [isovaleryl-CoA dehydrogenase(Enzyme) wildtype]

2_Methylpropanoyl_CoA + Electron_transferring_flavoprotein -> Reduced_electron_transferring_flavoprotein + 2_Methylprop_2_enoyl_CoA		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM HEPES KOH, 1 mM KCN, 1 mM salicylhydroxamic acid, 50 µM FAD, 100 µg/ml phenazine methosulfate
PH: 8
Temperature: 30

Pathways

pathway id name
BioCyc:ARA_VALDEG-PWY L-valine degradation I
BioCyc:HUMAN_LEU-DEG2-PWY leucine degradation
BioCyc:ARA_LEU-DEG2-PWY L-leucine degradation I
BioCyc:MOUSE_PWY3DJ-6 Leucine Catabolism
BioCyc:MOUSE_LEU-DEG2-PWY leucine degradation I
Plant Reactome:R-OSA-1119479 Valine degradation
Plant Reactome:R-OSA-2744345 Metabolism and regulation
Plant Reactome:R-OSA-2744343 Amino acid metabolism
Plant Reactome:R-OSA-5655124 Amino acid catabolism
PlantCyc:ARA_VALDEG-PWY L-valine degradation I
PlantCyc:PLANT_VALDEG-PWY L-valine degradation I
PlantCyc:ARA_LEU-DEG2-PWY L-leucine degradation I
PlantCyc:PLANT_LEU-DEG2-PWY L-leucine degradation I
Reactome:R-HSA-70895 Branched-chain amino acid catabolism
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-70895 Branched-chain amino acid catabolism
Reactome:R-RNO-70895 Branched-chain amino acid catabolism
Reactome:R-HSA-71291 Amino acid and derivative metabolism
Reactome:R-MMU-71291 Amino acid and derivative metabolism
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-71291 Amino acid and derivative metabolism
Reactome:R-HSA-1430728 Metabolism
WikiPathways:WP4686 Leucine, isoleucine and valine metabolism
PathBank:SMP0120662 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I
PathBank:SMP0120806 3-Hydroxyisobutyric Aciduria
PathBank:SMP0000032 Valine, Leucine, and Isoleucine Degradation
PathBank:SMP0000173 beta-Ketothiolase Deficiency
PathBank:SMP0000199 Maple Syrup Urine Disease
PathBank:SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency
PathBank:SMP0000141 3-Methylglutaconic Aciduria Type IV
PathBank:SMP0000524 Isovaleric Acidemia
PathBank:SMP0087234 Valine, Leucine, and Isoleucine Degradation
PathBank:SMP0120661 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency
PathBank:SMP0120665 3-Methylglutaconic Aciduria Type IV
PathBank:SMP0120745 Methylmalonic Aciduria
PathBank:SMP0120757 Propionic Acidemia
PathBank:SMP0120805 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency
PathBank:SMP0000138 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency
PathBank:SMP0000140 3-Methylglutaconic Aciduria Type III
PathBank:SMP0000238 Isovaleric Aciduria
PathBank:SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency
PathBank:SMP0087172 Fatty Acid Metabolism
PathBank:SMP0087265 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids
PathBank:SMP0120660 2-Methyl-3-hydroxybutryl-CoA Dehydrogenase Deficiency
PathBank:SMP0120664 3-Methylglutaconic Aciduria Type III
PathBank:SMP0120736 Maple Syrup Urine Disease
PathBank:SMP0120808 Isovaleric Acidemia
PathBank:SMP0000137 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency
PathBank:SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I
PathBank:SMP0000200 Methylmalonic Aciduria
PathBank:SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency
PathBank:SMP0002460 Valine Degradation
PathBank:SMP0120663 3-Methylglutaconic Aciduria Type I
PathBank:SMP0120679 beta-Ketothiolase Deficiency
PathBank:SMP0120723 Isovaleric Aciduria
PathBank:SMP0120743 Methylmalonate Semialdehyde Dehydrogenase Deficiency
PathBank:SMP0120807 Isobutyryl-CoA Dehydrogenase Deficiency
PathBank:SMP0000236 Propionic Acidemia
PathBank:SMP0000139 3-Methylglutaconic Aciduria Type I
PathBank:SMP0000522 3-Hydroxyisobutyric Aciduria
PathBank:SMP0000635 Valproic Acid Metabolism Pathway
PathBank:SMP0087267 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids
PathBank:SMP0087327 Valine, Leucine, and Isoleucine Degradation