EC: 1.1.1.170

3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (3beta-hydroxysteroid-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating))

enzyme lambda metabolic reaction experiment
uniprot:Q5PPL3 [sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)(Enzyme) wildtype]

3beta_Hydroxy_4beta_methyl_5alpha_cholest_7_ene_4alpha_carboxylate + NAD+ -> H+ + NADH + CO2 + 4alpha_Methyl_5alpha_cholest_7_en_3_one		 (( (Vmax * A) ) / (Km + A)) buffer: 0.1 M Potassium phosphate
PH: 9
Temperature: 37

Pathways

pathway id name
BioCyc:META_PWY-6074 zymosterol biosynthesis
BioCyc:HUMAN_PWY66-5 superpathway of cholesterol biosynthesis
BioCyc:HUMAN_PWY66-341 cholesterol biosynthesis I
BioCyc:META_PWY66-341 cholesterol biosynthesis I
BioCyc:META_PWY66-4 cholesterol biosynthesis III (via desmosterol)
BioCyc:YEAST_ERGOSTEROL-SYN-PWY superpathway of ergosterol biosynthesis
BioCyc:MOUSE_PWY66-341 cholesterol biosynthesis I
BioCyc:HUMAN_PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
BioCyc:HUMAN_PWY-6074 zymosterol biosynthesis
BioCyc:META_PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
BioCyc:HUMAN_PWY66-4 cholesterol biosynthesis III (via desmosterol)
BioCyc:META_ERGOSTEROL-SYN-PWY superpathway of ergosterol biosynthesis I
BioCyc:META_PWY66-5 superpathway of cholesterol biosynthesis
BioCyc:YEAST_PWY-6074 zymosterol biosynthesis
BioCyc:MOUSE_PWY66-4 cholesterol biosynthesis III (via desmosterol)
Reactome:R-BTA-1430728 Metabolism
Reactome:R-BTA-556833 Metabolism of lipids
Reactome:R-BTA-191273 Cholesterol biosynthesis
Reactome:R-HSA-6807047 Cholesterol biosynthesis via desmosterol (Bloch pathway)
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-556833 Metabolism of lipids
Reactome:R-MMU-8957322 Metabolism of steroids
Reactome:R-RNO-6807062 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)
Reactome:R-SCE-8957322 Metabolism of steroids
Reactome:R-SPO-1430728 Metabolism
Reactome:R-SPO-6807062 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)
Reactome:R-BTA-8957322 Metabolism of steroids
Reactome:R-HSA-556833 Metabolism of lipids
Reactome:R-HSA-191273 Cholesterol biosynthesis
Reactome:R-MMU-6807062 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)
Reactome:R-RNO-6807047 Cholesterol biosynthesis via desmosterol (Bloch pathway)
Reactome:R-SCE-1430728 Metabolism
Reactome:R-SCE-6807062 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)
Reactome:R-SPO-6807047 Cholesterol biosynthesis via desmosterol (Bloch pathway)
Reactome:R-BTA-6807047 Cholesterol biosynthesis via desmosterol (Bloch pathway)
Reactome:R-HSA-6807062 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)
Reactome:R-MMU-191273 Cholesterol biosynthesis
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-556833 Metabolism of lipids
Reactome:R-RNO-8957322 Metabolism of steroids
Reactome:R-SCE-556833 Metabolism of lipids
Reactome:R-SCE-191273 Cholesterol biosynthesis
Reactome:R-SPO-8957322 Metabolism of steroids
Reactome:R-BTA-6807062 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-8957322 Metabolism of steroids
Reactome:R-MMU-6807047 Cholesterol biosynthesis via desmosterol (Bloch pathway)
Reactome:R-RNO-191273 Cholesterol biosynthesis
Reactome:R-SCE-6807047 Cholesterol biosynthesis via desmosterol (Bloch pathway)
Reactome:R-SPO-556833 Metabolism of lipids
Reactome:R-SPO-191273 Cholesterol biosynthesis
WikiPathways:WP4346 Cholesterol metabolism with Bloch and Kandutsch-Russell pathways
PathBank:SMP0120794 Mevalonic Aciduria
PathBank:SMP0121057 Bloch Pathway (Cholesterol Biosynthesis)
PathBank:SMP0000023 Steroid Biosynthesis
PathBank:SMP0000387 CHILD Syndrome
PathBank:SMP0000112 Risedronate Action Pathway
PathBank:SMP0000508 Cholesteryl Ester Storage Disease
PathBank:SMP0002438 Cholesterol Biosynthesis and Metabolism CE(12:0)
PathBank:SMP0087326 Steroid Biosynthesis
PathBank:SMP0120685 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2)
PathBank:SMP0120769 Hypercholesterolemia
PathBank:SMP0120793 Hyper-IgD Syndrome
PathBank:SMP0000389 Smith-Lemli-Opitz Syndrome (SLOS)
PathBank:SMP0000319 Lysosomal Acid Lipase Deficiency (Wolman Disease)
PathBank:SMP0000082 Simvastatin Action Pathway
PathBank:SMP0000111 Cerivastatin Action Pathway
PathBank:SMP0000131 Atorvastatin Action Pathway
PathBank:SMP0000511 Wolman Disease
PathBank:SMP0002381 Steroid Biosynthesis
PathBank:SMP0002436 Cholesterol biosynthesis and metabolism CE(10:0)
PathBank:SMP0002441 Cholesterol biosynthesis and metabolism CE(18:0)
PathBank:SMP0087233 Steroid Biosynthesis
PathBank:SMP0120684 CHILD Syndrome
PathBank:SMP0120692 Desmosterolosis
PathBank:SMP0120732 Lysosomal Acid Lipase Deficiency (Wolman Disease)
PathBank:SMP0120792 Cholesteryl Ester Storage Disease
PathBank:SMP0070041 Cholesterol Biosynthesis and Metabolism
PathBank:SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis)
PathBank:SMP0000386 Desmosterolosis
PathBank:SMP0000089 Pravastatin Action Pathway
PathBank:SMP0000095 Alendronate Action Pathway
PathBank:SMP0000099 Lovastatin Action Pathway
PathBank:SMP0000117 Pamidronate Action Pathway
PathBank:SMP0000509 Hyper-IgD Syndrome
PathBank:SMP0120735 Smith-Lemli-Opitz Syndrome (SLOS)
PathBank:SMP0120795 Wolman Disease
PathBank:SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2)
PathBank:SMP0000079 Ibandronate Action Pathway
PathBank:SMP0000092 Rosuvastatin Action Pathway
PathBank:SMP0000209 Hypercholesterolemia
PathBank:SMP0000107 Zoledronate Action Pathway
PathBank:SMP0000119 Fluvastatin Action Pathway
PathBank:SMP0000510 Mevalonic Aciduria
PathBank:SMP0002435 Cholesterol biosynthesis and metabolism CE(14:0)
PathBank:SMP0002440 Cholesterol Biosynthesis and Metabolism CE(16:0)