EC: 1.2.1.8

betaine-aldehyde dehydrogenase (betaine-aldehyde:NAD+ oxidoreductase)

enzyme lambda metabolic reaction experiment
uniprot:P49419 [betaine-aldehyde dehydrogenase(Enzyme) wildtype]

Betaine_aldehyde + H2O + NAD+ -> H+ + NADH + Betaine		 (( (Vmax * S) ) / (Km + S)) buffer: 75 mM sodium pyrophosphate, 1 mM pyrazole
PH: 8
Temperature: 25
- [betaine-aldehyde dehydrogenase(Enzyme) wildtype]

H2O + NAD+ + Betaine_aldehyde -> NADH + H+ + Betaine		 (( (Vmax * S) ) / (Km + S)) buffer: 80 mM sodium phosphate
PH: 7.5
Temperature: 37
- [betaine-aldehyde dehydrogenase(Enzyme) wildtype]

Betaine_aldehyde + NAD+ + H2O -> Betaine + H+ + NADH		 (( (Vmax * S) ) / (Km + S)) buffer: 80 mM sodium phosphate
PH: 7.5
Temperature: 37
- [betaine-aldehyde dehydrogenase(Enzyme) wildtype]

Betaine_aldehyde + H2O + NADP+ -> NADPH + H+ + Betaine		 (( (Vmax * S) ) / (Km + S)) buffer: 80 mM sodium phosphate
PH: 7.5
Temperature: 37
uniprot:P49189 [betaine-aldehyde dehydrogenase(Enzyme) wildtype]

Betaine_aldehyde + NAD+ + H2O -> NADH + Betaine + H+		 (( (Vmax * A) ) / (Km + A)) buffer: 0.1 M Sodium phosphate, 1 mM EDTA
PH: 7.4
Temperature: 25

Pathways

pathway id name
BioCyc:HUMAN_PWY66-414 superpathway of choline degradation to L-serine
BioCyc:META_LYSINE-DEG1-PWY L-lysine degradation XI (mammalian)
BioCyc:ECOO157_BETSYN-PWY glycine betaine biosynthesis I (Gram-negative bacteria)
BioCyc:ECOO157_CHOLINE-BETAINE-ANA-PWY choline degradation I
BioCyc:AGRO_BETSYN-PWY glycine betaine biosynthesis I (Gram-negative bacteria)
BioCyc:BSUB_PWY-3722 glycine betaine biosynthesis II (Gram-positive bacteria)
BioCyc:HUMAN_LYSINE-DEG1-PWY lysine degradation I (saccharopine pathway)
BioCyc:META_CHOLINE-BETAINE-ANA-PWY choline degradation I
BioCyc:ECO_BETSYN-PWY glycine betaine biosynthesis I (Gram-negative bacteria)
BioCyc:AGRO_P542-PWY choline-O-sulfate degradation
BioCyc:MOUSE_PWY-2501 fatty acid α-oxidation
BioCyc:MOUSE_PWY66-21 ethanol degradation II (cytosol)
BioCyc:ECOL316407_BETSYN-PWY glycine betaine biosynthesis I (Gram-negative bacteria)
BioCyc:META_PWY-5327 superpathway of L-lysine degradation
BioCyc:META_PWY-3722 glycine betaine biosynthesis II (Gram-positive bacteria)
BioCyc:ARA_PWY-2 putrescine degradation IV
BioCyc:AGRO_CHOLINE-BETAINE-ANA-PWY choline degradation I
BioCyc:HUMAN_CHOLINE-BETAINE-ANA-PWY choline degradation
BioCyc:META_P542-PWY choline-O-sulfate degradation
BioCyc:META_PWY1F-353 glycine betaine biosynthesis III (plants)
BioCyc:META_BETSYN-PWY glycine betaine biosynthesis I (Gram-negative bacteria)
BioCyc:META_PWY-2 putrescine degradation IV
BioCyc:ARA_PWY1F-353 glycine betaine biosynthesis III (plants)
BioCyc:MOUSE_PWY-0 putrescine degradation III
BioCyc:MOUSE_PWY-3981 β-alanine biosynthesis I
PlantCyc:ARA_PWY1F-353 glycine betaine biosynthesis III (plants)
PlantCyc:BARLEY_CHOLINE-BETAINE-ANA-PWY choline degradation I
PlantCyc:PLANT_PWY1F-353 glycine betaine biosynthesis III (plants)
PlantCyc:PLANT_PWY-2 putrescine degradation IV
PlantCyc:PLANT_CHOLINE-BETAINE-ANA-PWY choline degradation I
PlantCyc:ARA_PWY-2 putrescine degradation IV
PlantCyc:BARLEY_PWY1F-353 glycine betaine biosynthesis III (plants)
Reactome:R-HSA-71064 Lysine catabolism
Reactome:R-HSA-6798163 Choline catabolism
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-71064 Lysine catabolism
Reactome:R-MMU-6798163 Choline catabolism
Reactome:R-RNO-71064 Lysine catabolism
Reactome:R-RNO-6798163 Choline catabolism
Reactome:R-HSA-71291 Amino acid and derivative metabolism
Reactome:R-MMU-71291 Amino acid and derivative metabolism
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-71291 Amino acid and derivative metabolism
Reactome:R-HSA-1430728 Metabolism
WikiPathways:WP4288 MTHFR deficiency
PathBank:SMP0120440 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency
PathBank:SMP0120444 3-Methylglutaconic Aciduria Type IV
PathBank:SMP0120516 Maple Syrup Urine Disease
PathBank:SMP0120528 Methylmalonic Aciduria Due to Cobalamin-Related Disorders
PathBank:SMP0120589 Isovaleric Acidemia
PathBank:SMP0121276 Proline Metabolism
PathBank:SMP0122236 Putrescine Degradation II
PathBank:SMP0122256 Ethylene Glycol Degradation
PathBank:SMP0000239 Saccharopinuria/Hyperlysinemia II
PathBank:SMP0000528 Hyperlysinemia II or Saccharopinuria
PathBank:SMP0002313 Sarcosine Oncometabolite Pathway
PathBank:SMP0012047 Glycine Betaine Biosynthesis I
PathBank:SMP0063656 Propanoate Metabolism
PathBank:SMP0120439 2-Methyl-3-hydroxybutryl-CoA Dehydrogenase Deficiency
PathBank:SMP0120443 3-Methylglutaconic Aciduria Type III
PathBank:SMP0120459 beta-Ketothiolase Deficiency
PathBank:SMP0120503 Isovaleric Aciduria
PathBank:SMP0120523 Methylmalonate Semialdehyde Dehydrogenase Deficiency
PathBank:SMP0120588 Isobutyryl-CoA Dehydrogenase Deficiency
PathBank:SMP0121275 Ornithine Metabolism
PathBank:SMP0122227 D-Arabinose Degradation I
PathBank:SMP0122243 4-Aminobutanoate Degradation I
PathBank:SMP0000186 Glutaric Aciduria Type I
PathBank:SMP0000527 Hyperlysinemia I, Familial
PathBank:SMP0000571 Pyridoxine Dependency with Seizures
PathBank:SMP0063599 beta-Alanine Metabolism
PathBank:SMP0063689 Valine, Leucine, and Isoleucine Degradation
PathBank:SMP0120441 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I
PathBank:SMP0120525 Methylmalonic Aciduria
PathBank:SMP0120537 Propionic Acidemia
PathBank:SMP0120558 Carnosinuria, Carnosinemia
PathBank:SMP0120586 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency
PathBank:SMP0122245 L-Lactaldehyde Degradation (Aerobic)
PathBank:SMP0000123 Betaine Metabolism
PathBank:SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria
PathBank:SMP0087203 Lysine Degradation
PathBank:SMP0012048 Glycine Betaine Biosynthesis II
PathBank:SMP0120442 3-Methylglutaconic Aciduria Type I
PathBank:SMP0120478 GABA-Transaminase Deficiency
PathBank:SMP0120514 Malonic Aciduria
PathBank:SMP0120567 Malonyl-CoA Decarboxylase Deficiency
PathBank:SMP0120587 3-Hydroxyisobutyric Aciduria
PathBank:SMP0121274 Arginine Metabolism
PathBank:SMP0122246 Methylglyoxal Degradation IV
PathBank:SMP0000037 Lysine Degradation
PathBank:SMP0087182 Betaine Metabolism