Sarcosine Oncometabolite Pathway

Metabolites

5-Methyltetrahydrofolate

Formula: C20H25N7O6 (459.186623)

CAS ID: 134-35-0

ATP

Formula: C10H16N5O13P3 (506.9957476)

CAS ID: 56-65-5

Betaine

Formula: C5H11NO2 (117.0789746)

CAS ID: 107-43-7

Betaine aldehyde

Formula: C5H12NO (102.0918842)

CAS ID: 7418-61-3

Choline

Formula: C5H14NO (104.10753340000001)

CAS ID: 62-49-7

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

L-Methionine

Formula: C5H11NO2S (149.0510466)

CAS ID: 63-68-3

L-Serine

Formula: C3H7NO3 (105.0425912)

CAS ID: 56-45-1

N,N-Dimethylglycine

Formula: C4H9NO2 (103.0633254)

CAS ID: 1118-68-9

NAD+

Formula: C21H28N7O14P2 (664.1169428000001)

CAS ID: 53-84-9

NADH

Formula: C21H29N7O14P2 (665.1247674)

CAS ID: 58-68-4

Sarcosine

Formula: C3H7NO2 (89.0476762)

CAS ID: 107-97-1

diphosphate

Formula: O7P2 (173.911931)

CAS ID: 14000-31-8

phosphate(3-)

Formula: O4P (94.953423)

CAS ID: 14265-44-2



Enzyme

EC Number name full name note
1.1.99.1 choline dehydrogenase choline:acceptor 1-oxidoreductase
1.2.1.3 aldehyde dehydrogenase (NAD+) aldehyde:NAD+ oxidoreductase
1.2.1.31 L-aminoadipate-semialdehyde dehydrogenase L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase
1.2.1.8 betaine-aldehyde dehydrogenase betaine-aldehyde:NAD+ oxidoreductase
1.5.8.3 sarcosine dehydrogenase sarcosine, 5,6,7,8-tetrahydrofolate:electron-transferflavoprotein oxidoreductase (demethylating,5,10-methylenetetrahydrofolate-forming)
1.5.8.4 dimethylglycine dehydrogenase N,N-dimethylglycine,5,6,7,8-tetrahydrofolate:electron-transferflavoprotein oxidoreductase (demethylating,5,10-methylenetetrahydrofolate-forming)
2.1.1.13 methionine synthase 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
2.1.1.20 glycine N-methyltransferase S-adenosyl-L-methionine:glycine N-methyltransferase
2.1.1.5 betaine-homocysteine S-methyltransferase trimethylammonioacetate:L-homocysteine S-methyltransferase
2.1.2.1 glycine hydroxymethyltransferase 5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase
2.5.1.6 methionine adenosyltransferase ATP:L-methionine S-adenosyltransferase


Proteins

Protein ID name full name