EC: 2.6.1.39

2-aminoadipate transaminase (L-2-aminoadipate:2-oxoglutarate aminotransferase)

enzyme lambda metabolic reaction experiment
uniprot:Q8N5Z0 [Pyridoxal phosphate]

Glyoxylate + L_Glutamine -> 2_Oxoglutaramate + Glycine		 (( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 100 mM Potassium phosphate
PH: 7.4
Temperature: 37
uniprot:Q8N5Z0 [Pyridoxal phosphate]

Glyoxylate + L_Methionine -> 4_Methylthio_2_oxobutanoate + Glycine		 (( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 100 mM Potassium phosphate
PH: 7.4
Temperature: 37
uniprot:Q8N5Z0 [Pyridoxal phosphate]

Glyoxylate + L_2_Aminoadipate -> Glycine + 2_Oxoadipate		 (( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 100 mM Potassium phosphate
PH: 7.4
Temperature: 37
- [Pyridoxal phosphate]

L_Glutamate + 2_Oxoadipate + 2_Oxoadipate -> 2_Oxoglutarate + L_2_Aminoadipate		 (( (Vmax * S1) ) / (Km + S1)) buffer: 150 mM potassium phosphate
PH: 8
Temperature: 37
- [Pyridoxal phosphate]

2_Oxoglutarate + L_2_Aminoadipate -> 2_Oxoadipate + L_Glutamate + 2_Oxoadipate		 (( (Vmax * S2) ) / (Km + S2)) buffer: 150 mM potassium phosphate
PH: 8
Temperature: 37
- [Pyridoxal phosphate]

L_Glutamate + 2_Oxoadipate + 2_Oxoadipate -> 2_Oxoglutarate + L_2_Aminoadipate		 (( (Vmax * S2) ) / (Km + S2)) buffer: 150 mM potassium phosphate
PH: 8
Temperature: 37
- [Pyridoxal phosphate]

2_Oxoglutarate + L_2_Aminoadipate -> 2_Oxoadipate + 2_Oxoadipate + L_Glutamate		 (( (Vmax * S1) ) / (Km + S1)) buffer: 150 mM potassium phosphate
PH: 8
Temperature: 37
- [Pyridoxal phosphate]

L_2_Aminoadipate + 2_Oxoglutarate -> L_Glutamate + 2_Oxoadipate + 2_Oxoadipate		 (( (Vmax * S2) ) / (Km + S2)) buffer: 150 mM potassium phosphate
PH: 8
Temperature: 37
- [Pyridoxal phosphate]

L_Glutamate + 2_Oxoadipate + 2_Oxoadipate -> L_2_Aminoadipate + 2_Oxoglutarate		 (( (Vmax * S1) ) / (Km + S1)) buffer: 150 mM potassium phosphate
PH: 8
Temperature: 37
- [Pyridoxal phosphate]

2_Oxoglutarate + L_2_Aminoadipate -> 2_Oxoadipate + L_Glutamate + 2_Oxoadipate		 (( (Vmax * S1) ) / (Km + S1)) buffer: 150 mM potassium phosphate
PH: 8
Temperature: 37
- [Pyridoxal phosphate]

2_Oxoadipate + 2_Oxoadipate + L_Glutamate -> 2_Oxoglutarate + L_2_Aminoadipate		 (( (Vmax * S2) ) / (Km + S2)) buffer: 150 mM potassium phosphate
PH: 8
Temperature: 37

Pathways

pathway id name
BioCyc:HUMAN_PWY66-425 lysine degradation II (pipecolate pathway)
BioCyc:META_PHESYN L-phenylalanine biosynthesis I
BioCyc:META_LYSINE-DEG1-PWY L-lysine degradation XI (mammalian)
BioCyc:HUMAN_LYSINE-DEG1-PWY lysine degradation I (saccharopine pathway)
BioCyc:META_LYSINE-AMINOAD-PWY L-lysine biosynthesis IV
BioCyc:META_PWY-5754 4-hydroxybenzoate biosynthesis I (eukaryotes)
BioCyc:META_PWY-5079 L-phenylalanine degradation III
BioCyc:YEAST_PWY-5886 4-hydroxyphenylpyruvate biosynthesis
BioCyc:YEAST_PWY-5082 L-methionine degradation III
BioCyc:YEAST_PWY3O-4108 tyrosine degradation
BioCyc:YEAST_LYSINE-AMINOAD-PWY L-lysine biosynthesis IV
BioCyc:MOUSE_LYSINE-DEG1-PWY lysine degradation II
BioCyc:HUMAN_PWY-6309 L-kynurenine degradation
BioCyc:META_TYRSYN L-tyrosine biosynthesis I
BioCyc:META_PWY-5327 superpathway of L-lysine degradation
BioCyc:META_PWY3O-4108 L-tyrosine degradation III
BioCyc:YEAST_COMPLETE-ARO-YEAST-PWY superpathway of phenylalanine, tyrosine and tryptophan biosynthesis
BioCyc:YEAST_PWY3O-4120 tyrosine biosynthesis
BioCyc:YEAST_PWY-5081 tryptophan degradation VIII (to tryptophol)
BioCyc:META_PWY-5081 L-tryptophan degradation VIII (to tryptophol)
BioCyc:META_PWY66-425 L-lysine degradation II (L-pipecolate pathway)
BioCyc:META_ANAPHENOXI-PWY L-phenylalanine degradation II (anaerobic)
BioCyc:META_PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine)
BioCyc:META_PWY-5082 L-methionine degradation III
Reactome:R-HSA-71064 Lysine catabolism
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-71064 Lysine catabolism
Reactome:R-RNO-71064 Lysine catabolism
Reactome:R-HSA-71240 Tryptophan catabolism
Reactome:R-MMU-71240 Tryptophan catabolism
Reactome:R-RNO-71240 Tryptophan catabolism
Reactome:R-HSA-71291 Amino acid and derivative metabolism
Reactome:R-MMU-71291 Amino acid and derivative metabolism
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-71291 Amino acid and derivative metabolism
Reactome:R-HSA-1430728 Metabolism
WikiPathways:WP465 Tryptophan metabolism
WikiPathways:WP5355 Metabolic Epileptic Disorders
WikiPathways:WP5044 Kynurenine pathway and links to cell senescence
PathBank:SMP0120746 Saccharopinuria/Hyperlysinemia II
PathBank:SMP0120854 Pyridoxine Dependency with Seizures
PathBank:SMP0120870 2-Aminoadipic 2-Oxoadipic Aciduria
PathBank:SMP0000239 Saccharopinuria/Hyperlysinemia II
PathBank:SMP0000528 Hyperlysinemia II or Saccharopinuria
PathBank:SMP0002353 Tryptophan Metabolism
PathBank:SMP0087330 Tryptophan Metabolism
PathBank:SMP0000186 Glutaric Aciduria Type I
PathBank:SMP0000527 Hyperlysinemia I, Familial
PathBank:SMP0000571 Pyridoxine Dependency with Seizures
PathBank:SMP0002352 Tyrosine Metabolism
PathBank:SMP0120704 Glutaric Aciduria Type I
PathBank:SMP0120812 Hyperlysinemia II or Saccharopinuria
PathBank:SMP0000063 Tryptophan Metabolism
PathBank:SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria
PathBank:SMP0087300 Lysine Degradation
PathBank:SMP0120811 Hyperlysinemia I, Familial
PathBank:SMP0000037 Lysine Degradation
PathBank:SMP0002349 Phenylalanine Metabolism