Tryptophan Metabolism

Metabolites

2-Oxoglutarate

Formula: C5H6O5 (146.0215226)

CAS ID: 328-50-7

3-Hydroxyanthranilate

Formula: C7H7NO3 (153.0425912)

CAS ID: 548-93-6

Anthranilate

Formula: C7H7NO2 (137.0476762)

CAS ID: 118-92-3

Chorismate

Formula: C10H10O6 (226.04773600000001)

CAS ID: 617-12-9

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Glyceraldehyde 3-phosphate

Formula: C3H7O6P (169.9980252)

CAS ID: 591-59-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Indole

Formula: C8H7N (117.0578462)

CAS ID: 120-72-9

Indole-3-acetaldehyde

Formula: C10H9NO (159.06841039999998)

CAS ID: 2591-98-2

Indole-3-ethanol

Formula: C10H11NO (161.0840596)

CAS ID: 526-55-6

L-Alanine

Formula: C3H7NO2 (89.0476762)

CAS ID: 56-41-7

L-Glutamate

Formula: C5H9NO4 (147.0531554)

CAS ID: 56-86-0

L-Glutamine

Formula: C5H10N2O3 (146.069139)

CAS ID: 56-85-9

L-Kynurenine

Formula: C10H12N2O3 (208.0847882)

CAS ID: 2922-83-0

L-Phenylalanine

Formula: C9H11NO2 (165.0789746)

CAS ID: 63-91-2

L-Serine

Formula: C3H7NO3 (105.0425912)

CAS ID: 56-45-1

L-Tryptophan

Formula: C11H12N2O2 (204.0898732)

CAS ID: 73-22-3

NAD+

Formula: C21H28N7O14P2 (664.1169428000001)

CAS ID: 53-84-9

NADH

Formula: C21H29N7O14P2 (665.1247674)

CAS ID: 58-68-4

NADP+

Formula: C21H29N7O17P3 (744.0832754)

CAS ID: 53-59-8

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Phenylpyruvate

Formula: C9H8O3 (164.0473418)

CAS ID: 156-06-9

Pyruvate

Formula: C3H4O3 (88.0160434)

CAS ID: 127-17-3

N'-Formylkynurenine

Formula: C11H12N2O4 (236.07970319999998)

CAS ID: 1022-31-7

diphosphate

Formula: O7P2 (173.911931)

CAS ID: 14000-31-8



Enzyme

EC Number name full name note
1.6.-.-
1.1.1.2 alcohol dehydrogenase (NADP+) alcohol:NADP+ oxidoreductase
1.13.11.52 indoleamine 2,3-dioxygenase D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
1.13.11.6 3-hydroxyanthranilate 3,4-dioxygenase 3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing)
1.14.13.9 kynurenine 3-monooxygenase L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
2.4.2.18 anthranilate phosphoribosyltransferase N-(5-phospho-D-ribosyl)-anthranilate:diphosphate phospho-alpha-D-ribosyltransferase
2.6.1.39 2-aminoadipate transaminase L-2-aminoadipate:2-oxoglutarate aminotransferase
2.6.1.57 aromatic-amino-acid transaminase aromatic-amino-acid:2-oxoglutarate aminotransferase
2.6.1.7 kynurenine-oxoglutarate transaminase L-kynurenine:2-oxoglutarate aminotransferase
3.5.1.9 arylformamidase aryl-formylamine amidohydrolase
3.7.1.3 kynureninase L-kynurenine hydrolase
4.1.1.43 phenylpyruvate decarboxylase phenylpyruvate carboxy-lyase (phenylacetaldehyde-forming)
4.1.1.48 indole-3-glycerol-phosphate synthase 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase [cyclizing; 1-C-(indol-3-yl)glycerol-3-phosphate-forming]
4.1.1.72 branched-chain-2-oxoacid decarboxylase (3S)-3-methyl-2-oxopentanoate carboxy-lyase (2-methylbutanal-forming)
4.1.1.74 indolepyruvate decarboxylase 3-(indol-3-yl)pyruvate carboxy-lyase [(2-indol-3-yl)acetaldehyde-forming]
4.1.3.27 anthranilate synthase chorismate pyruvate-lyase (amino-accepting; anthranilate-forming)
4.2.1.20 tryptophan synthase L-serine hydro-lyase [adding 1-C-(indol-3-yl)glycerol 3-phosphate; L-tryptophan and glyceraldehyde-3-phosphate-forming]
5.3.1.24 phosphoribosylanthranilate isomerase N-(5-phospho-beta-D-ribosyl)anthranilate aldose-ketose-isomerase


Proteins

Protein ID name full name
P00899 TRP2 Anthranilate synthase component 1
P00912 TRP1 N-(5'-phosphoribosyl)anthranilate isomerase
P00931 TRP5 Tryptophan synthase
P00937 TRP3 Multifunctional tryptophan biosynthesis protein
P06169 PDC1 Pyruvate decarboxylase isozyme 1
P07285 TRP4 Anthranilate phosphoribosyltransferase
P16467 PDC5 Pyruvate decarboxylase isozyme 2
P25377 ADH7 NADP-dependent alcohol dehydrogenase 7
P26263 PDC6 Pyruvate decarboxylase isozyme 3
P38169 BNA4 Kynurenine 3-monooxygenase
P38840 ARO9 Aromatic amino acid aminotransferase 2
P47096 BNA1 3-hydroxyanthranilate 3,4-dioxygenase
P47125 BNA2 Indoleamine 2,3-dioxygenase
P53090 ARO8 Aromatic/aminoadipate aminotransferase 1
Q04066 BNA7 Kynurenine formamidase
Q04894 ADH6 NADP-dependent alcohol dehydrogenase 6
Q05979 BNA5 Kynureninase