lysine degradation II (pipecolate pathway)

Struys EA, Jansen EEW, Salomons GS. Human pyrroline-5-carboxylate reductase (PYCR1) acts on ?1-piperideine-6-carboxylate generating L-pipecolic acid. J of Inher Metab Disea. 2014 Jan 16;37(3):327–32. doi: 10.1007/s10545-013-9673-4.; Hallen A, Jamie JF, Cooper AJL. Lysine metabolism in mammalian brain: an update on the importance of recent discoveries. Amino Acids. 2013 Sep 17;45(6):1249–72. doi: 10.1007/s00726-013-1590-1.; FUJII T, MUKAIHARA M, AGEMATU H, TSUNEKAWA H. Biotransformation ofL-Lysine toL-Pipecolic Acid Catalyzed byL-Lysine 6-Aminotransferase and Pyrroline-5-carboxylate Reductase. Bioscience, Biotechnology, and Biochemistry. 2002 Jan;66(3):622–7. doi: 10.1271/bbb.66.622.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydrogen peroxide

Formula: H2O2 (34.0054792)

CAS ID: 7722-84-1

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8

pyridoxal 5'-phosphate(2-)

Formula: C8H8NO6P (245.0089238)

CAS ID:

L-lysinium(1+)

Formula: C6H15N2O2 (147.113347)

CAS ID: 56-87-1



Enzyme

EC Number name full name note
1.2.4.-
1.5.1.1 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] L-pipecolate/L-proline:NAD(P)+ 2-oxidoreductase
1.5.1.2 pyrroline-5-carboxylate reductase L-proline:NAD(P)+ 5-oxidoreductase
1.5.1.25 thiomorpholine-carboxylate dehydrogenase thiomorpholine-3-carboxylate:NAD(P)+ 5,6-oxidoreductase
1.5.3.1 sarcosine oxidase (formaldehyde-forming) sarcosine:oxygen oxidoreductase (demethylating)
1.5.3.7 L-pipecolate oxidase L-pipecolate:oxygen 1,6-oxidoreductase
2.6.1.39 2-aminoadipate transaminase L-2-aminoadipate:2-oxoglutarate aminotransferase
2.6.1.4 glycine transaminase glycine:2-oxoglutarate aminotransferase
2.6.1.63 kynurenine-glyoxylate transaminase L-kynurenine:glyoxylate aminotransferase (cyclizing)
2.6.1.7 kynurenine-oxoglutarate transaminase L-kynurenine:2-oxoglutarate aminotransferase
2.6.1.73 methionine-glyoxylate transaminase L-methionine:glyoxylate aminotransferase


Proteins

Protein ID name full name