4-hydroxybenzoate biosynthesis I (eukaryotes)

Payet LA, Leroux M, Willison JC, Kihara A, Pelosi L, Pierrel F. Mechanistic Details of Early Steps in Coenzyme Q Biosynthesis Pathway in Yeast. Cell Chem Biol. 2016 Oct 20;23(10):1241–50. doi: 10.1016/j.chembiol.2016.08.008. PMID: 27693056.; Podstolski A, Havkin-Frenkel D, Malinowski J, Blount JW, Kourteva G, Dixon RA. Unusual 4-hydroxybenzaldehyde synthase activity from tissue cultures of the vanilla orchid Vanilla planifolia. Phytochemistry. 2002 Nov;61(6):611–20. doi: 10.1016/s0031-9422(02)00285-6. PMID: 12423881.; Meganathan R. Ubiquinone biosynthesis in microorganisms. FEMS Microbiol Lett. 2001 Sep 25;203(2):131–9. doi: 10.1111/j.1574-6968.2001.tb10831.x. PMID: 11583838.

Metabolites

4-Hydroxybenzaldehyde

Formula: C7H6O2 (122.0367776)

CAS ID: 123-08-0

4-Hydroxybenzoate

Formula: C7H6O3 (138.03169259999999)

CAS ID: 99-96-7

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

(R+)-3-(4-hydroxyphenyl)lactate

Formula: C9H9O4 (181.0500814)

CAS ID:

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

acetate

Formula: C2H3O2 (59.0133038)

CAS ID: 71-50-1

3-(4-hydroxyphenyl)pyruvate

Formula: C9H7O4 (179.0344322)

CAS ID: 622-54-8

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

pyridoxal 5'-phosphate(2-)

Formula: C8H8NO6P (245.0089238)

CAS ID:



Enzyme

EC Number name full name note
1.2.1.3 aldehyde dehydrogenase (NAD+) aldehyde:NAD+ oxidoreductase
1.2.1.64 4-hydroxybenzaldehyde dehydrogenase (NAD+) 4-hydroxybenzaldehyde:NAD+ oxidoreductase
2.6.1.39 2-aminoadipate transaminase L-2-aminoadipate:2-oxoglutarate aminotransferase
2.6.1.5 tyrosine transaminase L-tyrosine:2-oxoglutarate aminotransferase
2.6.1.57 aromatic-amino-acid transaminase aromatic-amino-acid:2-oxoglutarate aminotransferase
2.6.1.7 kynurenine-oxoglutarate transaminase L-kynurenine:2-oxoglutarate aminotransferase


Proteins

Protein ID name full name
P38840 ARO9 Aromatic amino acid aminotransferase 2
P53090 ARO8 Aromatic/aminoadipate aminotransferase 1
Q04458 HFD1 Fatty aldehyde dehydrogenase HFD1