L-tryptophan degradation VIII (to tryptophol)

Dickinson JR, Salgado LEJ, Hewlins MJE. The Catabolism of Amino Acids to Long Chain and Complex Alcohols in Saccharomyces cerevisiae. Journal of Biological Chemistry. 2003 Mar;278(10):8028–34. doi: 10.1074/jbc.m211914200.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

Indole-3-acetaldehyde

Formula: C10H9NO (159.06841039999998)

CAS ID: 2591-98-2

Indole-3-ethanol

Formula: C10H11NO (161.0840596)

CAS ID: 526-55-6

2-oxo-3-phenylpropanoate

Formula: C9H7O3 (163.0395172)

CAS ID: 620-76-8

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

pyridoxal 5'-phosphate(2-)

Formula: C8H8NO6P (245.0089238)

CAS ID:



Enzyme

EC Number name full name note
1.1.1.-
1.1.1.1 alcohol dehydrogenase alcohol:NAD+ oxidoreductase
1.1.1.284 S-(hydroxymethyl)glutathione dehydrogenase S-(hydroxymethyl)glutathione:NAD+ oxidoreductase
1.1.1.54 allyl-alcohol dehydrogenase allyl-alcohol:NADP+ oxidoreductase
1.1.1.78 methylglyoxal reductase (NADH) (R)-lactaldehyde:NAD+ oxidoreductase
2.6.1.39 2-aminoadipate transaminase L-2-aminoadipate:2-oxoglutarate aminotransferase
2.6.1.57 aromatic-amino-acid transaminase aromatic-amino-acid:2-oxoglutarate aminotransferase
2.6.1.7 kynurenine-oxoglutarate transaminase L-kynurenine:2-oxoglutarate aminotransferase
4.1.1.43 phenylpyruvate decarboxylase phenylpyruvate carboxy-lyase (phenylacetaldehyde-forming)
4.1.1.72 branched-chain-2-oxoacid decarboxylase (3S)-3-methyl-2-oxopentanoate carboxy-lyase (2-methylbutanal-forming)
4.1.1.74 indolepyruvate decarboxylase 3-(indol-3-yl)pyruvate carboxy-lyase [(2-indol-3-yl)acetaldehyde-forming]
4.1.1.80 4-hydroxyphenylpyruvate decarboxylase 4-hydroxyphenylpyruvate carboxy-lyase (4-hydroxyphenylacetaldehyde-forming)


Proteins

Protein ID name full name
P00330 ADH1 Alcohol dehydrogenase 1
P00331 ADH2 Alcohol dehydrogenase 2
P06169 PDC1 Pyruvate decarboxylase isozyme 1
P07246 ADH3 Alcohol dehydrogenase 3, mitochondrial
P10127 ADH4 Alcohol dehydrogenase 4
P16467 PDC5 Pyruvate decarboxylase isozyme 2
P26263 PDC6 Pyruvate decarboxylase isozyme 3
P32771 SFA1 S-(hydroxymethyl)glutathione dehydrogenase
P38113 ADH5 Alcohol dehydrogenase 5
P38840 ARO9 Aromatic amino acid aminotransferase 2
P53090 ARO8 Aromatic/aminoadipate aminotransferase 1
Q06408 ARO10 Transaminated amino acid decarboxylase