EC: 7.6.2.1

P-type phospholipid transporter (ATP phosphohydrolase (P-type, phospholipid-flipping))

enzyme lambda metabolic reaction experiment
uniprot:P60752 [Di[3-deoxy-D-manno-octulosonyl]-lipid A]

ATP + H2O -> Phosphate + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM HEPES, 1 mM Dithiothreitol
PH: 7.5
Temperature: 37
uniprot:P60752 [Mg2+]

ATP + H2O -> ADP + Phosphate		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM HEPES, 1 mM Dithiothreitol
PH: 7.5
Temperature: 37

Pathways

pathway id name
Reactome:R-MMU-9029569 LXRs regulate gene expression linked to cholesterol transport and efflux
Reactome:R-MMU-9024446 LXR-mediated signaling
Reactome:R-HSA-9029569 LXRs regulate gene expression linked to cholesterol transport and efflux
Reactome:R-HSA-9024446 LXR-mediated signaling
Reactome:R-RNO-9748784 Drug ADME
Reactome:R-MMU-9757110 Prednisone ADME
Reactome:R-BTA-9709957 Sensory Perception
Reactome:R-HSA-9709957 Sensory Perception
Reactome:R-HSA-9757110 Prednisone ADME
Reactome:R-MMU-9709957 Sensory Perception
Reactome:R-MMU-9748784 Drug ADME
Reactome:R-HSA-9748784 Drug ADME
Reactome:R-RNO-9757110 Prednisone ADME
Reactome:R-BTA-2453902 The canonical retinoid cycle in rods (twilight vision)
Reactome:R-HSA-1369062 ABC transporters in lipid homeostasis
Reactome:R-HSA-400206 Regulation of lipid metabolism by PPARalpha
Reactome:R-HSA-2161517 Abacavir transmembrane transport
Reactome:R-HSA-392499 Metabolism of proteins
Reactome:R-MMU-1369062 ABC transporters in lipid homeostasis
Reactome:R-MMU-162582 Signaling Pathways
Reactome:R-MMU-2453902 The canonical retinoid cycle in rods (twilight vision)
Reactome:R-RNO-5683826 Surfactant metabolism
Reactome:R-RNO-382551 Transport of small molecules
Reactome:R-BTA-2187338 Visual phototransduction
Reactome:R-HSA-382556 ABC-family proteins mediated transport
Reactome:R-HSA-8963898 Plasma lipoprotein assembly
Reactome:R-HSA-556833 Metabolism of lipids
Reactome:R-HSA-2161522 Abacavir ADME
Reactome:R-HSA-9006931 Signaling by Nuclear Receptors
Reactome:R-MMU-382556 ABC-family proteins mediated transport
Reactome:R-MMU-8963898 Plasma lipoprotein assembly
Reactome:R-MMU-2187338 Visual phototransduction
Reactome:R-RNO-392499 Metabolism of proteins
Reactome:R-BTA-382551 Transport of small molecules
Reactome:R-HSA-1989781 PPARA activates gene expression
Reactome:R-HSA-2187338 Visual phototransduction
Reactome:R-MMU-9006931 Signaling by Nuclear Receptors
Reactome:R-MMU-392499 Metabolism of proteins
Reactome:R-MMU-5683826 Surfactant metabolism
Reactome:R-RNO-382556 ABC-family proteins mediated transport
Reactome:R-BTA-382556 ABC-family proteins mediated transport
Reactome:R-HSA-382551 Transport of small molecules
Reactome:R-HSA-174824 Lipoprotein metabolism
Reactome:R-HSA-8963896 HDL assembly
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-162582 Signaling Pathways
Reactome:R-HSA-2453902 The canonical retinoid cycle in rods (twilight vision)
Reactome:R-HSA-5683826 Surfactant metabolism
Reactome:R-MMU-382551 Transport of small molecules
Reactome:R-MMU-174824 Lipoprotein metabolism
Reactome:R-MMU-8963896 HDL assembly
Reactome:R-RNO-1369062 ABC transporters in lipid homeostasis
WikiPathways:WP5176 Disorders of bile acid synthesis and biliary transport
WikiPathways:WP5238 Cholestasis
WikiPathways:WP5396 Enterohepatic circulation of bile acids
PathBank:SMP0000435 Docetaxel Action Pathway
PathBank:SMP0000439 Vinorelbine Action Pathway
PathBank:SMP0000601 Etoposide Metabolism Pathway
PathBank:SMP0000649 Lamivudine Metabolism Pathway
PathBank:SMP0002425 Lysolipid Incorporation into ER
PathBank:SMP0002492 Lysolipid incorporation into Mitochondria PC(16:0/16:0)
PathBank:SMP0002515 Lysolipid Incorporation into ER PC(16:1(9Z)/16:1(9Z))
PathBank:SMP0002519 Lysolipid Incorporation into ER PC(18:2(9Z,11Z)/18:2(9Z,11Z))
PathBank:SMP0002523 Lysolipid incorporation into Mitochondria PC(16:1(9Z)/16:1(9Z))
PathBank:SMP0002527 Lysolipid incorporation into Mitochondria PC(18:2(9Z,11Z)/18:2(9Z,11Z))
PathBank:SMP0031694 Imatinib Inhibition of BCR-ABL
PathBank:SMP0000434 Paclitaxel Action Pathway
PathBank:SMP0000438 Vindesine Action Pathway
PathBank:SMP0000472 Erlotinib Action Pathway
PathBank:SMP0000600 Irinotecan Metabolism Pathway
PathBank:SMP0000636 Venlafaxine Metabolism Pathway
PathBank:SMP0000640 Acetaminophen Metabolism Pathway
PathBank:SMP0000652 Mycophenolic Acid Metabolism Pathway
PathBank:SMP0002424 Lysolipid Incorporation into Mitochondria
PathBank:SMP0002514 Lysolipid Incorporation into ER PC(16:0/16:0)
PathBank:SMP0002518 Lysolipid Incorporation into ER PC(18:1(9Z)/18:1(9Z))
PathBank:SMP0002522 Lysolipid incorporation into Mitochondria PC(14:0/14:0)
PathBank:SMP0002526 Lysolipid incorporation into Mitochondria PC(18:1(9Z)/18:1(9Z))
PathBank:SMP0000436 Vinblastine Action Pathway
PathBank:SMP0000442 Etoposide Action Pathway
PathBank:SMP0000610 Clopidogrel Metabolism Pathway
PathBank:SMP0000650 Doxorubicin Metabolism Pathway
PathBank:SMP0002512 Lysolipid Incorporation into ER PC(10:0/10:0)
PathBank:SMP0002516 Lysolipid Incorporation into ER PC(16:1(11Z)/16:1(11Z))
PathBank:SMP0002520 Lysolipid Incorporation into ER PC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))
PathBank:SMP0002524 Lysolipid incorporation into Mitochondria PC(16:1(11Z)/16:1(11Z))
PathBank:SMP0002528 Lysolipid incorporation into Mitochondria PC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))
PathBank:SMP0000433 Irinotecan Action Pathway
PathBank:SMP0000437 Vincristine Action Pathway
PathBank:SMP0000260 Clopidogrel Action Pathway
PathBank:SMP0002513 Lysolipid Incorporation into ER PC(14:0/14:0)
PathBank:SMP0002517 Lysolipid Incorporation into ER PC(18:0/18:0)
PathBank:SMP0002521 Lysolipid incorporation into Mitochondria PC(10:0/10:0)
PathBank:SMP0002525 Lysolipid incorporation into Mitochondria PC(18:0/18:0)