Cholestasis

Koh S, Takada T, Kukuu I, Suzuki H. FIC1-mediated stimulation of FXR activity is decreased with PFIC1 mutations in HepG2 cells. Journal of Gastroenterology. 2009 Apr 21;44(6):592–600. doi: 10.1007/s00535-009-0041-y.

Metabolites

Acetyl-CoA

Formula: C23H38N7O17P3S (809.1257688000001)

CAS ID: 72-89-9

Cholesterol

Formula: C27H46O (386.3548466)

CAS ID: 57-88-5

Glutathione

Formula: C10H17N3O6S (307.08380220000004)

CAS ID: 70-18-8

HCO3-

Formula: HCO3 (60.9925696)

CAS ID: 71-52-3



Enzyme

EC Number name full name note
7.6.2.-
3.3.2.9 microsomal epoxide hydrolase cis-stilbene-oxide hydrolase
7.6.2.1 P-type phospholipid transporter ATP phosphohydrolase (P-type, phospholipid-flipping)
7.6.2.2 ABC-type xenobiotic transporter ATP phosphohydrolase (ABC-type, xenobiotic-exporting)
7.6.2.3 ABC-type glutathione-S-conjugate transporter ATP + H2O + glutathione-S-conjugate[side 1] = ADP + phosphate + glutathione-S-conjugate[side 2]


Proteins

Protein ID name full name