EC: 3.1.3.86

phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase (1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase)

enzyme lambda metabolic reaction experiment
uniprot:Q9SKB7 [Mg2+]

Phosphatidylinositol_3,4,5_trisphosphate + H2O -> 1_Phosphatidyl_1D_myo_inositol_3,4_bisphosphate + Phosphate
(( (Vmax * A) ) / (Km + A)) buffer: 50 mM Tris-HCl, 0.25% beta-D-octylglucoside, 1 mM PMSF
PH: 7
Temperature: 30

Pathways

pathway id name
BioCyc:HUMAN_PWY-6352 3-phosphoinositide biosynthesis
BioCyc:META_PWY-6352 3-phosphoinositide biosynthesis
BioCyc:META_PWY-6358 superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism
BioCyc:ARA_PWY-6363 D-myo-inositol (1,4,5)-trisphosphate degradation
BioCyc:ARA_PWY-6352 3-phosphoinositide biosynthesis
BioCyc:MOUSE_PWY3DJ-219 PIP metabolism
BioCyc:HUMAN_PWY-6364 D-myo-inositol (1,3,4)-trisphosphate biosynthesis
BioCyc:META_PWY-6362 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)
BioCyc:META_PWY-6368 3-phosphoinositide degradation
BioCyc:META_PWY-6363 D-myo-inositol (1,4,5)-trisphosphate degradation
BioCyc:META_PWY-6364 D-myo-inositol (1,3,4)-trisphosphate biosynthesis
BioCyc:ARA_PWY-6364 D-myo-inositol (1,3,4)-trisphosphate biosynthesis
BioCyc:MOUSE_PWY-6352 3-phosphoinositide biosynthesis
BioCyc:MOUSE_PWY-6358 superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism
BioCyc:HUMAN_PWY-6368 3-phosphoinositide degradation
BioCyc:HUMAN_PWY-6362 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)
BioCyc:HUMAN_PWY-6363 D-myo-inositol (1,4,5)-trisphosphate degradation
BioCyc:HUMAN_PWY-6358 superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism
BioCyc:MOUSE_PWY-6363 D-myo-inositol (1,4,5)-trisphosphate degradation
BioCyc:HUMAN_PWY-6371 superpathway of inositol phosphate compounds
PlantCyc:ARA_PWY-6352 3-phosphoinositide biosynthesis
PlantCyc:ARA_PWY-6363 D-myo-inositol (1,4,5)-trisphosphate degradation
PlantCyc:PLANT_PWY-6363 D-myo-inositol (1,4,5)-trisphosphate degradation
PlantCyc:ARA_PWY-6364 D-myo-inositol (1,3,4)-trisphosphate biosynthesis
Reactome:R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells
Reactome:R-RNO-210990 PECAM1 interactions
Reactome:R-DRE-1660499 Synthesis of PIPs at the plasma membrane
Reactome:R-HSA-210990 PECAM1 interactions
Reactome:R-MMU-168256 Immune System
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-556833 Metabolism of lipids
Reactome:R-MMU-1483255 PI Metabolism
Reactome:R-MMU-1660516 Synthesis of PIPs at the early endosome membrane
Reactome:R-RNO-5624958 ARL13B-mediated ciliary trafficking of INPP5E
Reactome:R-RNO-109582 Hemostasis
Reactome:R-RNO-202733 Cell surface interactions at the vascular wall
Reactome:R-RNO-1280218 Adaptive Immune System
Reactome:R-HSA-5617833 Cilium Assembly
Reactome:R-HSA-556833 Metabolism of lipids
Reactome:R-HSA-1660514 Synthesis of PIPs at the Golgi membrane
Reactome:R-HSA-1660516 Synthesis of PIPs at the early endosome membrane
Reactome:R-HSA-202403 TCR signaling
Reactome:R-HSA-202424 Downstream TCR signaling
Reactome:R-MMU-202733 Cell surface interactions at the vascular wall
Reactome:R-MMU-5620920 Cargo trafficking to the periciliary membrane
Reactome:R-MMU-5624958 ARL13B-mediated ciliary trafficking of INPP5E
Reactome:R-RNO-1852241 Organelle biogenesis and maintenance
Reactome:R-RNO-5617833 Cilium Assembly
Reactome:R-RNO-168256 Immune System
Reactome:R-DRE-1430728 Metabolism
Reactome:R-DRE-556833 Metabolism of lipids
Reactome:R-DRE-1483255 PI Metabolism
Reactome:R-HSA-5620920 Cargo trafficking to the periciliary membrane
Reactome:R-HSA-5624958 ARL13B-mediated ciliary trafficking of INPP5E
Reactome:R-HSA-109582 Hemostasis
Reactome:R-HSA-1483257 Phospholipid metabolism
Reactome:R-HSA-1483255 PI Metabolism
Reactome:R-HSA-168256 Immune System
Reactome:R-MMU-1280218 Adaptive Immune System
Reactome:R-MMU-1483257 Phospholipid metabolism
Reactome:R-MMU-1660517 Synthesis of PIPs at the late endosome membrane
Reactome:R-MMU-210990 PECAM1 interactions
Reactome:R-MMU-1852241 Organelle biogenesis and maintenance
Reactome:R-MMU-5617833 Cilium Assembly
Reactome:R-RNO-5620920 Cargo trafficking to the periciliary membrane
Reactome:R-RNO-202403 TCR signaling
Reactome:R-RNO-202424 Downstream TCR signaling
Reactome:R-DRE-1483257 Phospholipid metabolism
Reactome:R-HSA-1852241 Organelle biogenesis and maintenance
Reactome:R-HSA-202733 Cell surface interactions at the vascular wall
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-1660517 Synthesis of PIPs at the late endosome membrane
Reactome:R-HSA-1280218 Adaptive Immune System
Reactome:R-HSA-1280215 Cytokine Signaling in Immune system
Reactome:R-MMU-202403 TCR signaling
Reactome:R-MMU-202424 Downstream TCR signaling
Reactome:R-MMU-1660514 Synthesis of PIPs at the Golgi membrane
Reactome:R-MMU-109582 Hemostasis
WikiPathways:WP4971 Phosphoinositides metabolism
WikiPathways:WP5199 PtdIns(4,5)P2 in cytokinesis pathway
PathBank:SMP0063630 Inositol Phosphate Metabolism
PathBank:SMP0120865 Joubert Syndrome
PathBank:SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells
PathBank:SMP0000011 Inositol Metabolism
PathBank:SMP0000463 Phosphatidylinositol Phosphate Metabolism
PathBank:SMP0063629 Inositol Metabolism
PathBank:SMP0063651 Phosphatidylinositol Phosphate Metabolism
PathBank:SMP0120646 Joubert Syndrome
PathBank:SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells
PathBank:SMP0000582 Joubert Syndrome
PathBank:SMP0087351 Phosphatidylinositol Phosphate Metabolism