TCR signaling

Rudd CE, Schneider H. Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling. Nat Rev Immunol. 2003 Jul;3(7):544–56. doi: 10.1038/nri1131. PMID: 12876557.; van Leeuwen JE, Samelson LE. T cell antigen-receptor signal transduction. Curr Opin Immunol. 1999 Jun;11(3):242–8. doi: 10.1016/s0952-7915(99)80040-5. PMID: 10375551.; Rudd CE. Adaptors and molecular scaffolds in immune cell signaling. Cell. 1999 Jan 08;96(1):5–8. doi: 10.1016/s0092-8674(00)80953-8. PMID: 9989491.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
3.1.3.-
2.3.2.23 E2 ubiquitin-conjugating enzyme S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.10 IkappaB kinase ATP:[IkappaB protein] phosphotransferase
2.7.11.13 protein kinase C ATP:protein phosphotransferase (diacylglycerol-dependent)
2.7.11.25 mitogen-activated protein kinase kinase kinase ATP:protein phosphotransferase (MAPKKKK-activated)
3.1.3.16 protein-serine/threonine phosphatase protein-serine/threonine-phosphate phosphohydrolase
3.1.3.36 phosphoinositide 5-phosphatase phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase
3.1.3.48 protein-tyrosine-phosphatase protein-tyrosine-phosphate phosphohydrolase
3.1.3.56 inositol-polyphosphate 5-phosphatase 1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase
3.1.3.67 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase
3.1.3.86 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase
3.1.4.11 phosphoinositide phospholipase C 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase


Proteins

Protein ID name full name