Synthesis of PIPs at the plasma membrane

Zou J, Zhang C, Marjanovic J, Kisseleva MV, Majerus PW, Wilson MP. Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9539–44. PMID: 22647598; PMCID: PMC3386095.; Clarke JH, Wang M, Irvine RF. Localization, regulation and function of Type II phosphatidylinositol 5-phosphate 4-kinases. Advances in Enzyme Regulation. 2010;50(1):12–8. doi: 10.1016/j.advenzreg.2009.10.006.; Berger P, Berger I, Schaffitzel C, Tersar K, Volkmer B, Suter U. Multi-level regulation of myotubularin-related protein-2 phosphatase activity by myotubularin-related protein-13/set-binding factor-2. Hum Mol Genet. 2006 Feb 15;15(4):569–79. doi: 10.1093/hmg/ddi473. PMID: 16399794.; Gurung R, Tan A, Ooms LM, McGrath MJ, Huysmans RD, Munday AD, Prescott M, Whisstock JC, Mitchell CA. Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation. J Biol Chem. 2003 Mar 28;278(13):11376–85. doi: 10.1074/jbc.m209991200. PMID: 12536145.; Schaletzky J, Dove SK, Short B, Lorenzo O, Clague MJ, Barr FA. Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases. Curr Biol. 2003 Mar 18;13(6):504–9. doi: 10.1016/s0960-9822(03)00132-5. PMID: 12646134.; Kim S, Taylor GS, Torgersen KM, Dixon JE. Myotubularin and MTMR2, Phosphatidylinositol 3-Phosphatases Mutated in Myotubular Myopathy and Type 4B Charcot-Marie-Tooth Disease. Journal of Biological Chemistry. 2002 Feb;277(6):4526–31. doi: 10.1074/jbc.m111087200.; Guo S, Stolz LE, Lemrow SM, York JD. SAC1-like Domains of Yeast SAC1,INP52, and INP53 and of Human Synaptojanin Encode Polyphosphoinositide Phosphatases. Journal of Biological Chemistry. 1999 May;274(19):12990–5. doi: 10.1074/jbc.274.19.12990.; Tolias KF, Rameh LE, Ishihara H, Shibasaki Y, Chen J, Prestwich GD, Cantley LC, Carpenter CL. Type I Phosphatidylinositol-4-phosphate 5-Kinases Synthesize the Novel Lipids Phosphatidylinositol 3,5-Bisphosphate and Phosphatidylinositol 5-Phosphate. Journal of Biological Chemistry. 1998 Jul;273(29):18040–6. doi: 10.1074/jbc.273.29.18040.; Zhang X, Loijens JC, Boronenkov IV, Parker GJ, Norris FA, Chen J, Thum O, Prestwich GD, Majerus PW, Anderson RA. Phosphatidylinositol-4-phosphate 5-Kinase Isozymes Catalyze the Synthesis of 3-Phosphate-containing Phosphatidylinositol Signaling Molecules. Journal of Biological Chemistry. 1997 Jul;272(28):17756–61. doi: 10.1074/jbc.272.28.17756.; Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, Higashi K, Volinia S, Downward J, Waterfield MD. P110delta, a novel phosphoinositide 3-kinase in leukocytes. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4330–5. PMID: 9113989; PMCID: PMC20722.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.1.149 1-phosphatidylinositol-5-phosphate 4-kinase ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase
3.1.3.86 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase
3.1.3.95 phosphatidylinositol-3,5-bisphosphate 3-phosphatase 1-phosphatidyl-1D-myo-inositol-3,5-bisphosphate 3-phosphohydrolase
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name