EC: 1.14.14.55

quinine 3-monooxygenase (quinine,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase)

enzyme lambda metabolic reaction experiment
uniprot:P08684 [quinine 3-monooxygenase(Enzyme) wildtype]

O2 + Pradefovir + NADPH -> NADP+ + H2O + Adefovir		 (( (Vmax * A) ) / (Km + A)) buffer: 50 mM Potassium phosphate
PH: 7.4
Temperature: 37
uniprot:P08684 [Androst-4-ene-3,17-dione]

NADPH + Nevirapine + O2 + H+ -> H2O + 2_Hydroxy_nevirapine + NADP+		 (( (V * substrate) ) / (Km + substrate)) buffer: 100 mM potassium phosphate, 0.1 mM EDTA, 0.33 mM NADP+, 8 mM glucose 6-phosphate, 0.1 unit of glucose 6-phosphate dehydrogenase, 6 mM MgCl2
PH: 7.4
Temperature: 36
uniprot:P08684 [Aldosterone]

Nevirapine + NADPH + O2 + H+ -> H2O + 2_Hydroxy_nevirapine + NADP+		 (( (V * substrate) ) / (Km + substrate)) buffer: 100 mM potassium phosphate, 0.1 mM EDTA, 0.33 mM NADP+, 8 mM glucose 6-phosphate, 0.1 unit of glucose 6-phosphate dehydrogenase, 6 mM MgCl2
PH: 7.4
Temperature: 36
uniprot:P08684 [quinine 3-monooxygenase(Enzyme) wildtype]

Nevirapine + H+ + NADPH + O2 -> H2O + NADP+ + 2_Hydroxy_nevirapine		 (( (V * substrate) ) / (Km + substrate)) buffer: 100 mM potassium phosphate, 0.1 mM EDTA, 0.33 mM NADP+, 8 mM glucose 6-phosphate, 0.1 unit glucose 6-phosphate dehydrogenase, 6 mM MgCl2
PH: 7.4
Temperature: 36
uniprot:P08684 [Androst-4-ene-3,17-dione]

H+ + NADPH + O2 + Carbamazepine -> H2O + NADP+ + Carbamazepine_10,11_epoxide		 (( (V * substrate) ) / (Km + substrate)) buffer: 100 mM potassium phosphate, 0.1 mM EDTA, 0.33 mM NADP+, 8 mM glucose 6-phosphate, 0.1 unit of glucose 6-phosphate dehydrogenase, 6 mM MgCl2
PH: 7.4
Temperature: 36
uniprot:P08684 [Aldosterone]

NADPH + H+ + O2 + Carbamazepine -> H2O + Carbamazepine_10,11_epoxide + NADP+		 (( (V * substrate) ) / (Km + substrate)) buffer: 100 mM potassium phosphate, 0.1 mM EDTA, 0.33 mM NADP+, 8 mM glucose 6-phosphate, 0.1 unit of glucose 6-phosphate dehydrogenase, 6 mM MgCl2
PH: 7.4
Temperature: 36
uniprot:P08684 [Estradiol-17beta]

NADPH + Nevirapine + O2 + H+ -> NADP+ + H2O + 2_Hydroxy_nevirapine		 (( (V * substrate) ) / (Km + substrate)) buffer: 100 mM potassium phosphate, 0.1 mM EDTA, 0.33 mM NADP+, 8 mM glucose 6-phosphate, 0.1 unit of glucose 6-phosphate dehydrogenase, 6 mM MgCl2
PH: 7.4
Temperature: 36
uniprot:P08684 [Estradiol-17beta]

NADPH + O2 + Carbamazepine + H+ -> H2O + NADP+ + Carbamazepine_10,11_epoxide		 (( (V * substrate) ) / (Km + substrate)) buffer: 100 mM potassium phosphate, 0.1 mM EDTA, 0.33 mM NADP+, 8 mM glucose 6-phosphate, 0.1 unit of glucose 6-phosphate dehydrogenase, 6 mM MgCl2
PH: 7.4
Temperature: 36

Pathways

pathway id name
BioCyc:META_PWY-5270 morphine biosynthesis
Reactome:R-HSA-9754706 Atorvastatin ADME
Reactome:R-HSA-9757110 Prednisone ADME
Reactome:R-HSA-9748784 Drug ADME
Reactome:R-HSA-211859 Biological oxidations
Reactome:R-HSA-211945 Phase I - Functionalization of compounds
Reactome:R-HSA-1430728 Metabolism
WikiPathways:WP5280 Glucocorticoid biosynthesis
WikiPathways:WP4545 Oxysterols derived from cholesterol
WikiPathways:WP2536 Colchicine metabolic pathway
WikiPathways:WP4174 Metabolism of tetrahydrocannabinol (THC)
PathBank:SMP0000028 Caffeine Metabolism
PathBank:SMP0000439 Vinorelbine Action Pathway
PathBank:SMP0000447 Cyclophosphamide Action Pathway
PathBank:SMP0000327 Phenytoin (Antiarrhythmic) Action Pathway
PathBank:SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway
PathBank:SMP0000422 Imipramine Action Pathway
PathBank:SMP0000426 Fluoxetine Action Pathway
PathBank:SMP0000601 Etoposide Metabolism Pathway
PathBank:SMP0000605 Ifosfamide Metabolism Pathway
PathBank:SMP0000621 Codeine Metabolism Pathway
PathBank:SMP0000625 Imipramine Metabolism Pathway
PathBank:SMP0000633 Felbamate Metabolism Pathway
PathBank:SMP0000637 Tramadol Metabolism Pathway
PathBank:SMP0000641 Doxepin Metabolism Pathway
PathBank:SMP0000086 Ibuprofen Action Pathway
PathBank:SMP0000405 Codeine Action Pathway
PathBank:SMP0000600 Irinotecan Metabolism Pathway
PathBank:SMP0000604 Cyclophosphamide Metabolism Pathway
PathBank:SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway
PathBank:SMP0000624 Methadone Metabolism Pathway
PathBank:SMP0000636 Venlafaxine Metabolism Pathway
PathBank:SMP0000640 Acetaminophen Metabolism Pathway
PathBank:SMP0000644 Celecoxib Metabolism Pathway
PathBank:SMP0000648 Sorafenib Metabolism Pathway
PathBank:SMP0000652 Mycophenolic Acid Metabolism Pathway
PathBank:SMP0000074 Retinol Metabolism
PathBank:SMP0000336 Vitamin A Deficiency
PathBank:SMP0000436 Vinblastine Action Pathway
PathBank:SMP0000442 Etoposide Action Pathway
PathBank:SMP0000448 Ifosfamide Action Pathway
PathBank:SMP0000263 Cilostazol Action Pathway
PathBank:SMP0000328 Lidocaine (Antiarrhythmic) Action Pathway
PathBank:SMP0000590 Ibuprofen Metabolism Pathway
PathBank:SMP0000602 Teniposide Metabolism Pathway
PathBank:SMP0000606 Tamoxifen Metabolism Pathway
PathBank:SMP0000610 Clopidogrel Metabolism Pathway
PathBank:SMP0000634 Carbamazepine Metabolism Pathway
PathBank:SMP0000642 Nevirapine Metabolism Pathway
PathBank:SMP0000646 Fluoxetine Metabolism Pathway
PathBank:SMP0000096 Celecoxib Action Pathway
PathBank:SMP0000433 Irinotecan Action Pathway
PathBank:SMP0000443 Teniposide Action Pathway
PathBank:SMP0000471 Tamoxifen Action Pathway
PathBank:SMP0000260 Clopidogrel Action Pathway
PathBank:SMP0000408 Methadone Action Pathway
PathBank:SMP0000440 Prednisone Action Pathway
PathBank:SMP0000631 Prednisone Metabolism Pathway
PathBank:SMP0000639 Clomipramine Metabolism Pathway
PathBank:SMP0000651 Artemether Metabolism Pathway