Tamoxifen Metabolism Pathway

Metabolites

alpha-Hydroxytamoxifen

Formula: C26H29NO2 (387.2198174)

CAS ID: 97151-02-5

Endoxifen

Formula: C25H27NO2 (373.2041682)

CAS ID: 112093-28-4

Formaldehyde

Formula: CH2O (30.0105642)

CAS ID: 50-00-0

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydroxytamoxifen

Formula: C26H29NO2 (387.2198174)

CAS ID: 68047-06-3

N-Desmethyltamoxifen

Formula: C25H27NO (357.20925320000003)

CAS ID: 31750-48-8

N,N-Didesmethyltamoxifen

Formula: C24H25NO (343.193604)

CAS ID: 80234-20-4

NADP+

Formula: C21H29N7O17P3 (744.0832754)

CAS ID: 53-59-8

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Tamoxifen

Formula: C26H29NO (371.2249024)

CAS ID: 10540-29-1

Tamoxifen N-oxide

Formula: C26H29NO2 (387.2198174)

CAS ID: 75504-34-6

UDP

Formula: C9H14N2O12P2 (404.0021984)

CAS ID: 58-98-0

UDP-glucuronate

Formula: C15H22N2O18P2 (580.0342852)

CAS ID: 2616-64-0

Norendoxifen

Formula: C24H25NO2 (359.188519)

CAS ID: 1308808-22-1



Enzyme

EC Number name full name note
1.14.13.-
1.14.13.148 trimethylamine monooxygenase N,N,N-trimethylamine,NADPH:oxygen oxidoreductase (N-oxide-forming)
1.14.13.32 albendazole monooxygenase albendazole,NADPH:oxygen oxidoreductase (sulfoxide-forming)
1.14.13.8 flavin-containing monooxygenase N,N-dimethylaniline,NADPH:oxygen oxidoreductase (N-oxide-forming)
1.14.14.1 unspecific monooxygenase substrate,NADPH-hemoprotein reductase:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
1.14.14.55 quinine 3-monooxygenase quinine,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase
1.14.14.56 1,8-cineole 2-exo-monooxygenase 1,8-cineole,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (2-exo-hydroxylating)
1.14.14.73 albendazole monooxygenase (sulfoxide-forming) albendazole,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (sulfoxide-forming)
2.4.1.17 glucuronosyltransferase UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)
2.8.2.1 aryl sulfotransferase 3'-phosphoadenylyl-sulfate:phenol sulfotransferase


Proteins

Protein ID name full name