chorismate biosynthesis II (archaea)

Porat I, Sieprawska-Lupa M, Teng Q, Bohanon FJ, White RH, Whitman WB. Biochemical and genetic characterization of an early step in a novel pathway for the biosynthesis of aromatic amino acids and p-aminobenzoic acid in the archaeon Methanococcus maripaludis. Molecular Microbiology. 2006 Oct 13;62(4):1117–31. doi: 10.1111/j.1365-2958.2006.05426.x.; White RH. l-Aspartate Semialdehyde and a 6-Deoxy-5-ketohexose 1-Phosphate Are the Precursors to the Aromatic Amino Acids in Methanocaldococcus jannaschii. Biochemistry. 2004 May 20;43(23):7618–27. doi: 10.1021/bi0495127.

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Methylglyoxal

Formula: C3H4O2 (72.0211284)

CAS ID: 78-98-8

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

3-dehydroshikimate

Formula: C7H7O5 (171.02934720000002)

CAS ID:

L-aspartate(1-)

Formula: C4H6NO4 (132.0296816)

CAS ID:

shikimate

Formula: C7H9O5 (173.0449964)

CAS ID:

3-dehydroquinate

Formula: C7H9O6 (189.0399114)

CAS ID:

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

4-phosphonato-L-aspartic acid(2-)

Formula: C4H6NO7P (210.98818959999997)

CAS ID:

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8

beta-D-fructofuranose 1,6-bisphosphate(4-)

Formula: C6H10O12P2 (335.96475200000003)

CAS ID: 488-69-7



Enzyme

EC Number name full name note
1.1.1.25 shikimate dehydrogenase (NADP+) shikimate:NADP+ 3-oxidoreductase
1.2.1.11 aspartate-semialdehyde dehydrogenase L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating)
1.4.1.24 3-dehydroquinate synthase II 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate:NAD+ oxidoreductase (deaminating)
2.2.1.10 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase L-aspartate 4-semialdehyde:1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate methylglyoxaltransferase
2.2.1.11 6-deoxy-5-ketofructose 1-phosphate synthase 2-oxopropanal:D-fructose 1,6-bisphosphate glycerone-phosphotransferase
2.7.1.71 shikimate kinase ATP:shikimate 3-phosphotransferase
2.7.2.4 aspartate kinase ATP:L-aspartate 4-phosphotransferase
4.1.2.13 fructose-bisphosphate aldolase D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)
4.2.1.10 3-dehydroquinate dehydratase 3-dehydroquinate hydro-lyase (3-dehydroshikimate-forming)
5.3.1.1 triose-phosphate isomerase D-glyceraldehyde-3-phosphate aldose-ketose-isomerase


Proteins

Protein ID name full name
Q57658 asd Aspartate-semialdehyde dehydrogenase
Q57843 aroA' 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
Q57991 AK_METJA Probable aspartokinase
Q58484 aroE Shikimate dehydrogenase (NADP(+))
Q58646 aroB' 3-dehydroquinate synthase
Q58835 aroK Shikimate kinase
Q58923 tpiA Triosephosphate isomerase
Q58980 DKFP_METJA Fructose-bisphosphate aldolase/6-deoxy-5-ketofructose 1-phosphate synthase
Q6LXF7 aroD 3-dehydroquinate dehydratase