UDP-glucuronate (BioCAD00000019092)

liver placenta

Metabolite Card

Formula: C15H22N2O18P2 (580.0343)
SMILES: O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)O[C@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C(O)=O)O[C@H]([C@@H]1O)N1C=CC(=O)NC1=O

Synonyms [en]

UDP-glucuronate; uridine diphosphate glucuronic acid; UDP-alpha-D-glucuronate; UDP-D-glucuronate; Uridine 5'-diphosphoglucuronic acid; UDPglucuronate

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

UDP-glucuronate. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000019092). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

Uridine diphosphate glucuronic acid is a nucleoside diphosphate sugar which serves as a source of glucuronic acid for polysaccharide biosynthesis. It may also be epimerized to UDP Iduronic acid, which donates Iduronic acid to polysaccharides. In animals, UDP glucuronic acid is used for formation of many glucosiduronides with various aglycones. The transfer of glucuronic acid from UDP-alpha-D-glucuronic acid onto a terminal galactose residue is done by beta1,3-glucuronosyltransferases, responsible for the completion of the protein-glycosaminoglycan linkage region of proteoglycans and of the HNK1 epitope of glycoproteins and glycolipids. In humans the enzyme galactose-beta-1,3-glucuronosyltransferase I completes the synthesis of the common linker region of glycosaminoglycans (GAGs) by transferring glucuronic acid (GlcA) onto the terminal galactose of the glycopeptide primer of proteoglycans. The GAG chains of proteoglycans regulate major biological processes such as cell proliferation and recognition, extracellular matrix deposition, and morphogenesis. (PMID:16815917).

Endoplasmic reticulum Golgi apparatus
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 2616-64-0
  • CAS Registry Number: 63700-19-6
  • PubChem: 17473
  • PubChem: 9808366
  • ChEBI: ChEBI:17200
  • ChEBI: ChEBI:197331
  • HMDB: HMDB0000935
  • HMDB: HMDB00935
  • KEGG: C00167
  • NCBI MeSH: Uridine Diphosphate Glucuronic Acid
  • Wikipedia: Uridine_diphosphate_glucuronic_acid
  • DrugBank: DB03041
  • RefMet: RM0157921
  • MoNA: CCMSLIB00000578246
  • MoNA: CCMSLIB00005464602
  • MoNA: CCMSLIB00005720742
  • MoNA: FiehnHILIC001561
  • MoNA: MoNA024095
  • MoNA: MoNA024120
  • MoNA: MoNA034140
  • MoNA: MoNA034143
  • MoNA: MoNA034146
  • MoNA: MoNA037906
  • MoNA: PR100622
  • MoNA: PS037102
  • MoNA: PS037104
  • MoNA: PS037106
  • MoNA: PS037107
  • MoNA: PS037108
  • MoNA: PS037109
  • Metlin: METLIN_5884
  • Coconut NaturalProduct: CNP0289058.2
  • Coconut NaturalProduct: CNP0289058.4
  • Coconut NaturalProduct: CNP0605955.1

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R00286 1.1.1.22 UDP-glucose:NAD+ 6-oxidoreductase
KEGG:R01381 2.7.7.44 UTP:1-phospho-alpha-D-glucuronate uridylyltransferase
KEGG:R01383 2.4.1.17 UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)
KEGG:R01384 4.1.1.35 UDP-D-glucuronate carboxy-lyase (UDP-D-xylose-forming)
KEGG:R01385 5.1.3.6 UDP-glucuronate 4-epimerase
KEGG:R01386 UDP-D-glucuronate carboxy-lyase (UDP-D-apiose-forming)
KEGG:R01387 5.1.3.- UDP-glucuronate 5'-epimerase
KEGG:R02358 2.4.1.17 UDPglucuronate beta-D-glucuronosyltransferase(acceptor-unspecific)
KEGG:R02389 2.4.1.17 UDPglucuronate beta-D-glucuronosyltransferase(acceptor-unspecific)
KEGG:R02478 2.4.1.17 UDPglucuronate beta-D-glucuronosyltransferase(acceptor-unspecific)
KEGG:R02502 2.4.1.17 17beta-hydroxysteroid UDP-glucuronosyltransferase
KEGG:R02902 2.4.1.17 C00777 + C00167<=>C11061 + C00015
KEGG:R03091 2.4.1.17 UDPglucuronate beta-D-glucuronosyltransferase(acceptor-unspecific)
KEGG:R03589 2.4.1.189 UDPglucuronate:luteolin 7-O-glucuronosyltransferase
KEGG:R04352 2.4.1.17 UDPglucuronate beta-D-glucuronosyltransferase(acceptor-unspecific)
KEGG:R04353 2.4.1.17 UDPglucuronate beta-D-glucuronosyltransferase(acceptor-unspecific)
KEGG:R04354 2.4.1.17 UDPglucuronate beta-D-glucuronosyltransferase(acceptor-unspecific)
KEGG:R04607 2.4.1.135 UDPglucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein D-glucuronosyltransferase
KEGG:R04683 2.4.1.17 UDPglucuronate beta-D-glucuronosyltransferase(acceptor-unspecific)
KEGG:R05327 2.4.1.212 C00043 + C00167<=>C00518 + 2 C00015
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Organism Source

Taxonomy Source

  1. Arabidopsis thaliana [ncbi taxid: 3702]
  2. Escherichia coli [ncbi taxid: 562]
  3. Homo sapiens [ncbi taxid: 9606]
  4. Mus musculus [ncbi taxid: 10090]

Pathway Synthetic

pathway id name
BioCyc:TRYPANO_PWY-3821 galactose degradation III
BioCyc:TRYPANO_COLANSYN-PWY colanic acid building blocks biosynthesis
PathBank:SMP0000914 Amino Sugar and Nucleotide Sugar Metabolism III
PathBank:SMP0000967 Colanic Acid Building Blocks Biosynthesis
PathBank:SMP0002065 Polymyxin Resistance
Plant Reactome:R-OAU-2744345 Metabolism and regulation
Plant Reactome:R-OAU-2883407 Carbohydrate metabolism
Plant Reactome:R-CME-1119563 UDPXyl biosynthesis
Plant Reactome:R-TAE-2883407 Carbohydrate metabolism
Plant Reactome:R-FVE-1119563 UDPXyl biosynthesis
Plant Reactome:R-FVE-1119452 Galactose degradation II
Plant Reactome:R-MES-2744345 Metabolism and regulation
Plant Reactome:R-MES-5654909 Xylan biosynthesis
Plant Reactome:R-TDI-2744345 Metabolism and regulation
Plant Reactome:R-TDI-1119563 UDPXyl biosynthesis
Plant Reactome:R-TDI-1119452 Galactose degradation II
Plant Reactome:R-DRO-2744345 Metabolism and regulation
Plant Reactome:R-DRO-1119431 UDP-D-GlcA biosynthesis
Plant Reactome:R-DRO-1119452 Galactose degradation II
Plant Reactome:R-OGU-1119563 UDPXyl biosynthesis
View All Pathways