Metabolite Card
Formula: C30H33NO9 (551.2155)
SMILES: CC\C(=C(\C1=CC=C(O)C=C1)C1=CC=C(OCCNOC2O[C@H]([C@H](O)[C@@H](O)[C@@H]2O)C(O)=O)C=C1)C1=CC=CC=C1
Synonyms [en]
4-Hydroxytamoxifen-N-glucuronide; (2R,3R,4R,5S)-3,4,5-trihydroxy-6-[2-[4-[(E)-1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenoxy]ethylamino]oxyoxane-2-carboxylic acid; (2R,3R,4R,5S)-3,4,5-trihydroxy-6-{[(2-{4-[(1E)-1-(4-hydroxyphenyl)-2-phenylbut-1-en-1-yl]phenoxy}ethyl)amino]oxy}oxane-2-carboxylic acid
Last reviewed on 2024-06-28.
Cite this Page
4-Hydroxytamoxifen-N-glucuronide. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China.
https://biocad_registry.innovation.ac.cn/s/(-)-arctiin
(retrieved
2026-01-03) (CAD Registry RN: BioCAD00000056146). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Note
4-Hydroxytamoxifen-N-glucuronide is a metabolite of tamoxifen. Tamoxifen is an antagonist of the estrogen receptor in breast tissue via its active metabolite, hydroxytamoxifen. In other tissues such as the endometrium, it behaves as an agonist, and thus may be characterized as a mixed agonist/antagonist. Tamoxifen is the usual endocrine therapy for hormone receptor-positive breast cancer in pre-menopausal women, and is also a standard in post-menopausal women although aromatase inhibitors are also frequently used in that setting. (Wikipedia)
DBLinks
- CAS Registry Number:
- PubChem CID: 131770035
- ChEBI: 190865
- HMDB: HMDB0061124
- LipidMaps:
- KEGG:
- BioCyc:
- NCBI MeSH:
- Wikipedia:
Other DBLinks
- PubChem: 131770035
- ChEBI: ChEBI:190865
- HMDB: HMDB0061124
Class / Ontology
- WishartLab ClassyFire: [Stilbenes] Stilbenes
- ChEBI: [CHEBI:190865] 4-Hydroxytamoxifen-N-glucuronide
Taxonomy Source
Pathway Synthetic
| pathway id | name |
|---|---|
| PathBank:SMP0000606 | Tamoxifen Metabolism Pathway |
| PathBank:SMP0000471 | Tamoxifen Action Pathway |