Nicotinate metabolism

Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nature Reviews Molecular Cell Biology. 2020 Dec 22;22(2):119–41. doi: 10.1038/s41580-020-00313-x.; Cambronne XA, Kraus WL. Location, Location, Location: Compartmentalization of NAD+ Synthesis and Functions in Mammalian Cells. Trends in Biochemical Sciences. 2020 Oct;45(10):858–73. doi: 10.1016/j.tibs.2020.05.010.; Magni G, Amici A, Emanuelli M, Orsomando G, Raffaelli N, Ruggieri S. Enzymology of NAD+ homeostasis in man. Cellular and Molecular Life Sciences (CMLS). 2004 Jan 01;61(1):19–34. doi: 10.1007/s00018-003-3161-1.

Metabolites

1-Methylnicotinamide

Formula: C7H9N2O (137.0714844)

CAS ID: 3106-60-3

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydrogen peroxide

Formula: H2O2 (34.0054792)

CAS ID: 7722-84-1

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Nicotinamide

Formula: C6H6N2O (122.0480106)

CAS ID: 98-92-0

Nicotinamide-beta-riboside

Formula: C11H15N2O5 (255.098092)

CAS ID: 1341-23-7

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Sodium cation

Formula: Na (22.98977)

CAS ID: 17341-25-2

Urate

Formula: C5H4N4O3 (168.0283394)

CAS ID: 69-93-2

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

D-Ribosylnicotinate

Formula: C11H13NO6 (255.07428380000002)

CAS ID:

nicotinate

Formula: C6H4NO2 (122.0242024)

CAS ID:

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

deamido-NAD(2-)

Formula: C21H24N6O15P2 (662.0774854)

CAS ID:

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
3.2.2.-
1.6.3.5 renalase dihydro-NAD(P):oxygen oxidoreductase (H2O2-forming)
2.1.1.1 nicotinamide N-methyltransferase S-adenosyl-L-methionine:nicotinamide N-methyltransferase
2.4.2.12 nicotinamide phosphoribosyltransferase nicotinamide-D-ribonucleotide:diphosphate phospho-alpha-D-ribosyltransferase
2.4.2.19 nicotinate-nucleotide diphosphorylase (carboxylating) nicotinate-D-ribonucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating)
2.4.99.20 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase NADP+:nicotinate ADP-ribosyltransferase
2.7.1.173 nicotinate riboside kinase ATP:beta-D-ribosylnicotinate 5-phosphotransferase
2.7.1.22 ribosylnicotinamide kinase ATP:N-ribosylnicotinamide 5'-phosphotransferase
2.7.1.23 NAD+ kinase ATP:NAD+ 2'-phosphotransferase
2.7.7.1 nicotinamide-nucleotide adenylyltransferase ATP:nicotinamide-nucleotide adenylyltransferase
2.7.7.18 nicotinate-nucleotide adenylyltransferase ATP:nicotinate-ribonucleotide adenylyltransferase
3.1.3.35 thymidylate 5'-phosphatase thymidylate 5'-phosphohydrolase
3.1.3.5 5'-nucleotidase 5'-ribonucleotide phosphohydrolase
3.1.3.89 5'-deoxynucleotidase 2'-deoxyribonucleoside 5'-monophosphate phosphohydrolase
3.1.3.91 7-methylguanosine nucleotidase N7-methyl-GMP phosphohydrolase
3.1.3.99 IMP-specific 5'-nucleotidase inosine 5'-phosphate phosphohydrolase
3.2.2.6 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase NAD+ glycohydrolase (cyclic ADP-ribose-forming)
3.6.1.22 NAD+ diphosphatase NAD+ phosphohydrolase
4.2.1.93 ATP-dependent NAD(P)H-hydrate dehydratase (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ATP-hydrolysing; NADH-forming)
5.1.99.6 NAD(P)H-hydrate epimerase (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide 6-epimerase
6.3.4.21 nicotinate phosphoribosyltransferase 5-phospho-alpha-D-ribose 1-diphosphate:nicotinate ligase (ADP, diphosphate-forming)
6.3.5.1 NAD+ synthase (glutamine-hydrolysing) deamido-NAD+:L-glutamine amido-ligase (AMP-forming)


Proteins

Protein ID name full name