1-Methylnicotinamide (BioCAD00000001399)

blood feces urine placenta microbial natural products

Metabolite Card

Formula: C7H9N2O (137.0715)
SMILES: C[N+]1=CC=CC(=C1)C(N)=O

Synonyms [en]

1-methylnicotinamide; N(1)-methylnicotinamide; trigonellinamide; 3-(aminocarbonyl)-1-methylpyridinium; 1-methylnicotinamide cation; 1-methyl-3-carbamoylpyridinium

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

1-Methylnicotinamide. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000001399). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

1-Methylnicotinamide is a metabolite of nicotinamide and is produced primarily in the liver. It has anti-inflammatory properties (PMID 16197374). It is a product of nicotinamide N-methyltransferase [EC 2.1.1.1] in the pathway of nicotinate and nicotinamide metabolism (KEGG). 1-Methylnicotinamide may be an endogenous activator of prostacyclin production and thus may regulate thrombotic as well as inflammatory processes in the cardiovascular system (PMID: 17641676).

Cytoplasm Extracellular
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 1005-24-9
  • CAS Registry Number: 3106-60-3
  • PubChem: 457
  • ChEBI: ChEBI:16797
  • HMDB: HMDB0000699
  • KEGG: C02918
  • BioCyc: CPD-396
  • NCBI MeSH: N(1)-methylnicotinamide
  • Wikipedia: 1-Methylnicotinamide
  • DrugBank: DB11710
  • RefMet: RM0030166
  • MoNA: BAF_UVA_POS000958
  • MoNA: CCMSLIB00000577991
  • MoNA: EMBL_MCF_2_0_HRMS_Library000088
  • MoNA: FiehnHILIC000014
  • MoNA: FiehnHILIC001602
  • MoNA: HMDB0000699_ms_ms_972
  • MoNA: HMDB0000699_ms_ms_973
  • MoNA: HMDB0000699_ms_ms_974
  • MoNA: KO003442
  • MoNA: KO003443
  • MoNA: KO003444
  • MoNA: KO003445
  • MoNA: KO003446
  • MoNA: MoNA010621
  • MoNA: MoNA010622
  • MoNA: MoNA010623
  • MoNA: MoNA010624
  • MoNA: MoNA010625
  • MoNA: MoNA010626
  • MoNA: MoNA016626
  • MoNA: MoNA016806
  • MoNA: MoNA032128
  • MoNA: MoNA032130
  • MoNA: MoNA032131
  • MoNA: MoNA036056
  • MoNA: MoNA036058
  • MoNA: MoNA036062
  • MoNA: MoNA037176
  • MoNA: MoNA038567
  • MoNA: PR100411
  • MoNA: PR100412
  • MoNA: PS102701
  • MoNA: PS102702
  • MoNA: PS102703
  • Coconut NaturalProduct: CNP0212015.0

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R01269 2.1.1.1 S-adenosyl-L-methionine:nicotinamide N-methyltransferase
KEGG:R04085 1.2.3.1 aldehyde:oxygen oxidoreductase
KEGG:R08408 1.2.3.1 aldehyde:oxygen oxidoreductase
Rhea:RHEA:23885 2.1.1.1 nicotinamide + S-adenosyl-L-methionine => 1-methylnicotinamide + S-adenosyl-L-homocysteine
Rhea:RHEA:23886 2.1.1.1 1-methylnicotinamide + S-adenosyl-L-homocysteine => nicotinamide + S-adenosyl-L-methionine
Rhea:RHEA:23887 2.1.1.1 nicotinamide + S-adenosyl-L-methionine <=> 1-methylnicotinamide + S-adenosyl-L-homocysteine
Rhea:RHEA:73860 1-methylnicotinamide(out) => 1-methylnicotinamide(in)
Rhea:RHEA:73861 1-methylnicotinamide(in) => 1-methylnicotinamide(out)
Rhea:RHEA:73862 1-methylnicotinamide(out) <=> 1-methylnicotinamide(in)
BioCyc:NICOTINAMIDE-N-METHYLTRANSFERASE-RXN 2.1.1.1 S-ADENOSYLMETHIONINE + NIACINAMIDE --> ADENOSYL-HOMO-CYS + CPD-396
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Organism Source

Taxonomy Source

  1. Homo sapiens [ncbi taxid: 9606]
  2. Mus musculus [ncbi taxid: 10090]
  3. Saccharomyces cerevisiae [ncbi taxid: 4932]

Pathway Synthetic

pathway id name
Reactome:R-BTA-1430728 Metabolism
Reactome:R-BTA-556833 Metabolism of lipids
Reactome:R-BTA-196807 Nicotinate metabolism
Reactome:R-CEL-196807 Nicotinate metabolism
Reactome:R-CFA-1430728 Metabolism
Reactome:R-CFA-556833 Metabolism of lipids
Reactome:R-CFA-196807 Nicotinate metabolism
Reactome:R-DRE-8978868 Fatty acid metabolism
Reactome:R-DRE-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Reactome:R-DRE-196849 Metabolism of water-soluble vitamins and cofactors
Reactome:R-GGA-8978868 Fatty acid metabolism
Reactome:R-GGA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Reactome:R-HSA-196849 Metabolism of water-soluble vitamins and cofactors
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-556833 Metabolism of lipids
Reactome:R-MMU-196849 Metabolism of water-soluble vitamins and cofactors
Reactome:R-RNO-8978868 Fatty acid metabolism
Reactome:R-RNO-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Reactome:R-RNO-196849 Metabolism of water-soluble vitamins and cofactors
Reactome:R-SSC-196854 Metabolism of vitamins and cofactors
View All Pathways